3-(2-Hydroxyethyl)pyridine

3- (2-hydroxyethyl) pyridine has a wide range of uses. In the field of medicine, it is a key intermediate in drug synthesis. The construction of many drug molecules requires this as a starting material, and through various chemical reactions, specific functional groups are added to achieve the desired drug structure. This process is like building a delicate pavilion, and 3- (2-hydroxyethyl) pyridine is the solid cornerstone. In the field of organic synthesis, it can be used to prepare organic materials with special properties. With its unique chemical structure, it can react with other organic compounds to generate substances with novel structures and properties, which can be used in fields such as new polymer materials and functional coatings. It is like paving the way for the innovation and development of materials. In the dye industry, it also has a place. It can be used as an important raw material for the synthesis of specific dyes, giving them unique color and stability. Through fine synthesis steps, it is integrated into the molecular structure of dyes to meet the strict requirements of different industries for the performance of dyes. In short, 3- (2-hydroxyethyl) pyridine plays an indispensable role in many fields such as medicine, organic synthesis, dye industry, etc., like a shining pearl, illuminating the development of many industries.

3- (2-hydroxyethyl) pyridine is an organic compound with unique physical properties.
Looking at its properties, it is mostly a colorless to light yellow transparent liquid at room temperature, which is convenient for operation and application in many chemical reactions and industrial processes.
When it comes to the boiling point, it is about 220-222 ° C. This boiling point condition is of great significance in separation and purification. It can be separated from other substances with large differences in boiling points by means of distillation.
Besides, the melting point is about -20 ° C. This low-temperature melting point indicates that the substance is stable in a liquid state at room temperature. < Br >
Its density is about 1.06 - 1.07 g/cm ³, which is similar to that of water. In systems involving liquid-liquid mixing or stratification, this density property affects the distribution and interaction of substances.
In terms of solubility, 3- (2-hydroxyethyl) pyridine can be miscible with common organic solvents such as water, alcohols, and ethers. The property of being miscible with water makes it widely used in chemical reactions in aqueous systems, pharmaceutical preparations, etc.; miscible with organic solvents is conducive to being used as a reaction medium or participating in reactions in organic synthesis, expanding its use in the field of organic chemistry.
In addition, the substance has a certain degree of hygroscopicity. When storing and using, it is necessary to pay attention to the ambient humidity, otherwise it may affect its quality and performance. This hygroscopicity may be used in some specific application scenarios, such as as as an ingredient in humidity regulators.

There are several ways to make 3- (2-hydroxyethyl) pyridine in ancient times. One method is to use 2-methylpyridine as the starting material, and it can be obtained through oxidation and reduction steps. First, 2-methylpyridine is oxidized to carboxyl groups with an appropriate oxidizing agent, such as potassium permanganate or hydrogen peroxide, to obtain 2-pyridine carboxylic acid. This step requires attention to the temperature of the reaction and the amount of oxidant to prevent excessive oxidation. Afterwards, a strong reducing agent, such as lithium aluminum hydride, is used to reduce the carboxyl group to hydroxymethyl to obtain 3- (2-hydroxyethyl) pyridine. However, lithium aluminum hydride has strong activity and needs to be used with care. Operate in an anhydrous environment.
Another method is to use 2-vinylpyridine as a raw material. 2-vinylpyridine is epoxidized with a peroxy acid, such as m-chloroperoxybenzoic acid, to obtain 2- (ethylene oxide) pyridine. Subsequently, with appropriate nucleophiles, such as aqueous solution of sodium hydroxide, the epoxy ring is opened to introduce hydroxyl groups, and 3- (2-hydroxyethyl) pyridine can also be obtained. During this process, the epoxidation reaction needs to control the concentration of peroxy acid and the reaction time to avoid side reactions. During the ring-opening reaction, the type and concentration of nucleophiles affect the yield and purity of the product. < Br >
Another method is to directly react pyridine with ethylene oxide. Under the catalysis of appropriate catalysts, such as Lewis acid, such as aluminum trichloride or titanium tetrachloride, the nitrogen atom of pyridine conducts nucleophilic attack on the epoxy ring of ethylene oxide, and after opening the ring, 3- (2-hydroxyethyl) pyridine is formed. The key to this reaction lies in the selection and dosage of catalysts, as well as the regulation of reaction temperature and pressure to optimize the yield and selectivity of the reaction. All production methods have advantages and disadvantages. The actual application needs to be weighed according to factors such as the availability of raw materials, cost, and purity requirements of the product.

3- (2-hydroxyethyl) pyridine is a chemical substance, and many matters need to be paid attention to during storage and transportation.
Let's talk about storage first. First, choose a dry, cool and well-ventilated place. Because the humid environment is easy to cause it to absorb moisture, or affect the quality, and the high temperature may cause chemical reactions and cause it to deteriorate. Second, it should be stored separately from oxidants and acids. This is due to the nature of 3- (2-hydroxyethyl) pyridine. If it coexists with the above substances, or reacts violently, it is safe. Third, the storage container must be tightly sealed. To prevent leakage, not only to avoid waste, but also to avoid leakage or cause harm to the environment and people. Fourth, the storage area should be equipped with suitable leakage emergency treatment equipment and fire fighting equipment. In case of leakage, it can be disposed of in time to prevent the situation from expanding.
As for transportation. First and foremost, ensure that the packaging is intact. Stable and airtight packaging can avoid leakage due to vibration and collision during transportation. Second, the means of transportation should be clean and dry, and no other chemicals remain. Otherwise, residual substances may interact with 3- (2-hydroxyethyl) pyridine. Third, during transportation, it should be protected from sun exposure, rain and high temperature. Hot sun exposure and rain may affect its chemical properties. Fourth, transport personnel should be familiar with its properties and emergency treatment methods. In the event of an accident, it can respond quickly and properly to ensure the safety of personnel and the environment. In short, the storage and transportation of 3 - (2-hydroxyethyl) pyridine is related to safety and quality, and all aspects should not be ignored.

In today's world, business conditions change, and the price of 3- (2-hydroxyethyl) pyridine in the market is difficult to be constant. Its price often fluctuates due to various reasons, which cannot be covered in a single word.
One of the reasons is the trend of supply and demand. If the world is eager for 3- (2-hydroxyethyl) pyridine, and the supply is small, its price will rise; on the contrary, if supply exceeds demand, the stock is in the market, and the price will decline. This balance of supply and demand affects the direction of prices.
Second, the price of raw materials is also the key. The preparation of 3- (2-hydroxyethyl) pyridine requires specific raw materials. If the price of raw materials is high, the cost of forming this product will increase. In order to ensure their profits, merchants will raise their prices; if the price of raw materials decreases, the cost will also decrease, and the price may fall accordingly.
Third, government policies and regulations also have an impact. Government decrees, related to the regulation of the chemical industry, and the increase or decrease of taxes, can make the price of 3- (2-hydroxyethyl) pyridine change.
Fourth, the progress of technology cannot be ignored. If a new technique is developed, the method of making this substance will be easy and economical, and the quantity will increase and the cost will decrease, and the price will also change.
In today's market, the price of 3- (2-hydroxyethyl) pyridine may vary depending on the region, season, and quality. Probably at a certain time and place, the price of the superior is high, and the price of the inferior is low. If you want to know the real-time price, you must consult the market manager of chemical materials, the broker, or look at the news of the industry and the price table, and you can get a more accurate number. However, this price is also like a flow wave, which changes instantaneously and cannot be adhered to.