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What is the chemical structure of 3- (2- (3-Chloro phenyl) ethyl) -2-Pyridine Carbonitrile?
3- (2 - (3 - chlorophenyl) ethyl) -2 - pyridinyl nitrile has a chemical structure and is one of the organic compounds. This compound is composed of a pyridine ring and a specific substituent. The pyridine ring is a six-membered heterocyclic ring containing nitrogen, and its 2-position is connected with a formonitrile group (-CN). This formonitrile group has a certain chemical activity, which affects the reactivity of the compound.
In the 3-position of the pyridine ring, there is a 2 - (3 - chlorophenyl) ethyl substituent. In this substituent group, ethyl (-CH < unk > CH < unk >) is an alkane group, which has the characteristics of saturated hydrocarbons and is relatively stable. However, one end is connected to the pyridine ring, and the other end is connected with 3-chlorophenyl. The 3-chlorophenyl group is formed by the substitution of the benzene ring by the chlorine atom at the 3-position. The benzene ring has a conjugated π electron system, which endows the compound with certain stability and unique electronic effects. The existence of chlorine atoms, due to its high electronegativity, can affect the electron cloud distribution of the benzene ring and the whole molecule through induction and conjugation effects, and then have a significant effect on the physical and chemical properties of the compound, such as polarity, solubility, and reactivity. The overall structure of this compound makes it potentially valuable in organic synthesis, medicinal chemistry, and other fields.
What are the main uses of 3- (2- (3-Chloro phenyl) ethyl) -2-Pyridine Carbonitrile
3-%282-%283-Chloro+phenyl%29ethyl%29-2-Pyridine+Carbonitrile, the Chinese name or 3- (2- (3-chlorophenyl) ethyl) -2-pyridylmethonitrile. This compound has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry to create new drugs. Due to its unique chemical structure and activity, it can construct drug molecules that fit disease targets through specific chemical reactions.
In the field of materials science, or participate in the preparation of materials with special properties. If it is polymerized or modified with other substances, it imparts excellent properties such as optical, electrical or mechanical properties to materials to meet the strict requirements of special fields for material properties.
In the field of organic synthetic chemistry, it is an important synthetic building block. Chemists use its structural characteristics to carry out various organic reactions, expand the complexity of molecular structures, and synthesize organic compounds with novel structures and unique functions, providing a key material foundation for the development of organic synthetic chemistry. This compound plays an important role in many scientific research and industrial fields, promoting continuous progress and innovation in related fields.
What are the synthesis methods of 3- (2- (3-Chloro phenyl) ethyl) -2-Pyridine Carbonitrile
To prepare 3 - (2 - (3 - chlorophenyl) ethyl) - 2 - pyridineformonitrile, there are various ways to synthesize it. The following are common ones.
First, it can be achieved by the reaction of pyridine derivatives with halogenated phenethane derivatives. Take a suitable 2 - halogenated pyridine and make it react with halogenated ethane containing 3 - chlorophenyl in the presence of a base in a suitable solvent. Bases, such as potassium carbonate and sodium carbonate, can promote the reaction, grab the halogen atom of the halogen, and cause the nucleophilic substitution reaction between the two. The solvent can be selected as N, N-dimethylformamide (DMF), dimethylsulfoxide (DMSO) and other polar aprotic solvents. These solvents can improve the solubility of the reactants, and have a stable effect on the intermediate of the reaction, helping the reaction to occur smoothly, thereby generating the target product 3- (2- (3-chlorophenyl) ethyl) -2-pyridineformonitrile.
Second, 3-chlorophenyl vinyl is used as the starting material. First, 3-chlorophenyl vinyl is hydrocyanized to add double bonds to hydrocyanic acid to form an intermediate containing cyanide groups. Subsequently, the intermediate is reacted with the pyridine derivative, or through nucleophilic addition, substitution and other steps to construct the structure of the target product. In this process, the hydrocyanide reaction requires suitable catalysts, such as transition metal complexes, to improve the selectivity and efficiency of the reaction. The reaction with pyridine derivatives also requires careful regulation of the reaction conditions, such as temperature and reactant ratio, to achieve the best reaction effect.
Third, a pyridine ring can be constructed first, and then a side chain containing 3-chlorophenyl can be introduced. For example, the cyanide-containing pyridine precursor is coupled with a suitable halogen through a palladium-catalyzed coupling reaction to add a 2- (3-chlorophenyl) ethyl group. The palladium catalyst can activate the carbon-halogen bond of the halogen, making it easy to couple with the specific position of the pyridine ring. During the reaction, pay attention to the type of palladium catalyst, the choice of ligand, and the combination of base and solvent, all of which have a great impact on the success or failure of the reaction and the purity of the product.
The above synthesis methods have their own advantages and disadvantages. In practice, it is necessary to weigh and choose the optimal method according to the availability of raw materials, the difficulty of reaction, the consideration of cost and many other factors, so as to obtain high-purity 3- (2- (3-chlorophenyl) ethyl) -2 -pyridinetrile.
What are the physical properties of 3- (2- (3-Chloro phenyl) ethyl) -2-Pyridine Carbonitrile
3 - (2 - (3 - chlorophenyl) ethyl) - 2 - pyridinecarbonitrile, this is an organic compound, and its physical properties are of great research value.
Looking at its properties, under normal temperature and pressure, it is mostly in the shape of a solid state. As for the color, it often appears white or off-white, and the texture is relatively fine, like a powder. This property is quite common in many organic compounds.
When it comes to melting point, it is within a certain range. Melting point, as an important physical constant of a compound, is of great significance for the identification of its purity and the determination of its structure. The existence of the melting point of this substance indicates that within a specific temperature limit, its lattice structure will be destroyed, and the intermolecular forces will change, thus transforming from solid to liquid.
Solubility is also a key physical property. In common organic solvents, such as ethanol, acetone, etc., it has a certain solubility. However, in water, the solubility is relatively small. This difference is attributed to the characteristics of the molecular structure of the compound. The aromatic ring and nitrile groups it contains make the molecular polarity limited, and it is difficult to form a strong enough interaction with water molecules, so it is difficult to dissolve in water; while the intermolecular forces of organic solvents are more compatible with the compound, which is conducive to its dissolution and dispersion.
Furthermore, its density is also a specific value. Density reflects the mass of a substance per unit volume, and is related to the degree of molecular packing density and the relative molecular weight. The determination of the density of this compound plays an important guiding role in the design of the quantitative operation of substances and related reaction systems.
Its volatility is very weak, and the tendency of molecules to escape to the gas phase is small at room temperature. This is because because of the strong intermolecular force, molecules need to obtain more energy to break free and enter the gas phase. This property also affects its diffusion and stability in the environment.
What is the market outlook for 3- (2- (3-Chloro phenyl) ethyl) -2-Pyridine Carbonitrile?
Today, there are 3- (2- (3-chlorophenyl) ethyl) - 2-pyridinecarbonitrile, want to know its market prospects. This compound is widely used in the chemical industry. It is used at the end of pharmaceutical research and development, or as a key intermediate, to help create new drugs to deal with difficult diseases. Market demand increases with the development of the pharmaceutical industry. In the field of pesticides, there are also potential uses, which may improve crop protection efficiency and meet the needs of agricultural modernization for high-efficiency pesticides.
Looking at the current market, the pharmaceutical and pesticide industries are booming. In medicine, R & D investment continues to increase, and the demand for characteristic intermediates is increasing. If this compound can meet the stringent Quality Standards of pharmaceutical companies, it will be favored by pharmaceutical companies with its pharmacological activity given by its unique structure, and its market share is expected to expand. In the field of pesticides, green and efficient pesticides are the general trend of development. If it can have both high efficiency and low toxicity, and meet the demands of environmental protection, it will also occupy a place in the pesticide market.
However, its market development also has challenges. The synthesis process may need to be optimized to reduce costs and increase production in order to gain a foothold in the highly competitive market. And regulations are stricter, and strict safety and environmental assessments are required for both pharmaceutical and pesticide uses. But overall, if we can deal with it properly, 3- (2- (3-chlorophenyl) ethyl) -2-pyridinonitrile has a promising future and is expected to gain development opportunities in the pharmaceutical and pesticide markets.
