2 Trimethylsilyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

2-(Trimethylsilyl)pyridine

    Specifications

    HS Code

    648081

    Chemical Formula C8H13NSi
    Molar Mass 151.28 g/mol
    Appearance Colorless liquid
    Boiling Point 175 - 177 °C
    Density 0.917 g/mL at 25 °C
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
    Flash Point 56 °C
    Odor Characteristic pyridine - like odor
    Cas Number 13081 - 63 - 1

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    General Information
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    Frequently Asked Questions

    As a leading 2-(Trimethylsilyl)pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main application fields of 2- (trimethylsilyl) pyridine?
    The main functional domains of di- (trimethylsilyl) pyridine are:
    First, in the synthetic domain, the role of this compound is very important. Because the silicon group has specific sub-effects and empty effects, it can effectively lead to the reverse direction. For example, in arylated antibodies, di- (trimethylsilyl) pyridine can be filled with antibodies, gold-catalyzed coordination, and improve catalytic activity and performance. Just like in the catalytic carbon-carbon formation of antibodies, it can promote the antibodies to travel more efficiently in the direction of the target material, generating specific antibodies molecules. It is of great significance to build the skeleton of antibodies, and is widely used in the synthesis of antibodies and materials.
    Second, in the field of materials, di- (trimethylsilyl) pyridine also has a place. Due to its properties, it can be modified and prepared. For example, in the synthesis of some polymer materials, the introduction of this compound can improve the physical properties of the material, such as improving the qualitative and mechanical properties of the material. Its silicon-based part can affect the interaction of the polymer, and the material properties can be improved. This meets the special needs of material properties in different domains, and plays a role in the research of high-end domains such as aerospace and sub-devices.
    Third, in the field of chemical analysis, di- (trimethylsilyl) pyridine can be used for analysis. Because of its specific properties, it can assist in the qualitative and quantitative analysis of analytes. For example, in phase chromatography, it can be used for derivatization, generating easy-to-use or difficult-to-use derivatives with specific information, improving the sensitivity and accuracy of analysis, and is useful in environmental analysis, food analysis, and so on.
    What are the physical properties of 2- (trimethylsilyl) pyridine?
    Trimethylsilyl is a common group in organic silicon compounds. It has unique physical properties and is widely used in many fields.
    In the structure of trimethylsilyl, the central silicon atom is connected to three methyl groups. The outer layer of the silicon atom has four valence electrons, which can form covalent bonds with other atoms. The carbon atoms in the methyl group are connected to the silicon atom by a single bond, which gives trimethylsilyl some special properties.
    In terms of physical properties, trimethylsilyl groups have a relatively large mass and the methyl groups are arranged in three dimensions, which results in changes in the intermolecular forces of compounds containing trimethylsilyl groups. For example, the boiling and melting points of some organic compounds containing trimethylsilyl groups are affected. Due to the electron-pushing effect of methyl groups, trimethylsilyl groups have a certain electron-giving ability, which affects the electron cloud distribution of compounds, thereby affecting their chemical activity.
    In terms of solubility, trimethylsilyl groups enhance the solubility of compounds in organic solvents. Because methyl groups are hydrophobic groups, substances containing trimethylsilyl groups are more soluble in non-polar or weakly polar organic solvents, which is very important in organic synthesis, separation and purification. For example, in some organic reactions, the introduction of trimethylsilyl groups can dissolve the originally insoluble reactants in specific organic solvents, promoting the smooth progress of the reaction.
    In addition, trimethylsilyl groups also have certain chemical stability. The covalent bond formed by silicon and carbon is relatively strong, and it is not easy to break under some mild conditions, which allows compounds containing trimethylsilyl groups to exist stably in specific environments, laying the foundation for their application in different fields. Whether it is in organic synthesis as a protective group or in materials science to improve material properties, these physical properties of trimethylsilyl groups play a key role.
    What are the chemical synthesis methods of 2- (trimethylsilyl) pyridine?
    There are several methods for the synthesis of trimethylbenzyl. The most common one is the reaction of benzyl halide and trimethylamine. Take an appropriate amount of benzyl halide, place it in a reactor, slowly add the alcohol solution of trimethylamine, control the temperature and stir it. In this reaction, the halogen atom of benzyl halide is active and can be nucleophilically substituted with the nitrogen atom of trimethylamine to obtain trimethylbenzyl. After the reaction is completed, the pure product can be obtained by separation and purification.
    Second, it can be prepared by the catalytic reaction of benzyl alcohol and trimethylamine. First take the benzyl alcohol in the container, add an appropriate amount of catalyst, such as an acidic catalyst, and then pass into the trimethylamine gas. The hydroxyl group of benzyl alcohol is activated by a catalyst, and a series of reactions such as nucleophilic addition and dehydration occur with trimethylamine, resulting in trimethylbenzyl. In this process, the choice and amount of catalyst, reaction temperature and pressure, etc., are all related to the efficiency of the reaction and the purity of the product.
    Or from the corresponding aromatic hydrocarbons, through alkylation reaction. With aromatic hydrocarbons as substrates, and suitable alkylation reagents, such as halogenated alkanes, under the action of catalysts, trimethyl groups are introduced into the benzyl groups. In this case, the catalyst can promote the reaction of aromatic hydrocarbons and alkylation reagents, and guide the reaction to generate trimethylbenzyl groups. However, the reaction conditions need to be carefully regulated to prevent the generation of side reactions and impurity of
    All these synthetic methods have their own advantages and disadvantages. In practical application, the ideal synthetic effect can be achieved only when carefully selected according to many factors such as the availability of raw materials, cost considerations, and product purity requirements.
    What are the precautions for 2- (trimethylsilyl) pyridine during storage and transportation?
    Futrimethylbenzyl, when storing and transporting, many matters should be paid attention to.
    First of all, it is flammable. This is determined by its chemical properties, so when storing, it must choose a cool, dry and well-ventilated place, away from fire and heat sources. If the storage place is poorly ventilated, the accumulated steam will encounter open flames or hot topics, which can easily cause combustion, or even explosion, endangering the lives and property of the surrounding people.
    Second, the packaging requirements are very strict. The packaging must be strong and sealed to prevent leakage. Because if it leaks, it will not only cause material loss, but also the volatilized vapor will be diffused in the air, which will also pollute the environment, and if people inhale it or come into contact with it through skin, it may damage health. The packaging materials used must be able to withstand its chemical corrosion and not react with it.
    Furthermore, when transporting, it is necessary to strictly follow relevant regulations and standards. Transportation vehicles should be equipped with complete fire fighting equipment and emergency treatment equipment for emergencies. Drivers and escorts also need to be professionally trained to be familiar with their characteristics and emergency disposal methods. During transportation, always pay attention to changes in temperature and humidity to avoid violent vibrations and collisions to prevent package damage.
    In addition, trimethylbenzyl is corrosive to some materials. Storage containers and transportation pipelines, etc., should be made of compatible materials, such as specific metals or plastics, to prevent leakage due to corrosion.
    In short, in the whole process of storage and transportation of trimethylbenzyl, from environmental selection, packaging protection, to transportation specifications and personnel requirements, there should be no slack, so as to ensure safety and avoid accidents.
    What are the effects of 2- (trimethylsilyl) pyridine on the environment and human health?
    Triethanolamine oleic acid soap has various effects on the environment and human health.
    First talk about its impact on the environment. If this substance is released in nature, it will cause ecological or biological harm to the water body. It may cause eutrophication in the water body, because it contains nitrogen, phosphorus and other elements, too much of these elements, which is easy to cause algae and other plankton to grow wildly. Overgrowth of algae will deplete the dissolved oxygen in the water, causing aquatic organisms such as fish to die due to lack of oxygen, and breaking the ecological balance of the water body. And it also has an impact on the soil, which may change the physical and chemical properties of the soil, or affect the community structure and function of soil microorganisms, posing a threat to the stability and health of the soil ecosystem.
    As for the impact on human health. If human skin is exposed to triethanolamine oleic acid soap, it may cause allergic reactions, causing skin redness, swelling, itching, tingling and other discomfort. Due to the different sensitivity of individual skin, some people have poor tolerance to such chemicals. If you accidentally inhale its volatile mist, or irritate the respiratory tract, causing symptoms such as cough and asthma, long-term exposure to this environment, or increase the risk of respiratory diseases. If eaten by mistake, it can also cause gastrointestinal discomfort, such as nausea, vomiting, abdominal pain, etc. Because the substance is not a normal ingredient that can be digested and absorbed by the human body, it will disrupt the normal function of the stomach.
    Therefore, when using triethanolamine oleic acid soap, be careful and take protective measures to prevent adverse effects on the environment and human health.