2 Trifluoromethyl Pyridine 5 Sulfonyl Chloride
pyridine pyrrole pyrazine piperidine piperazine

2-(TRIFLUOROMETHYL)PYRIDINE-5-SULFONYL CHLORIDE

    Specifications

    HS Code

    285329

    Chemical Formula C6H3ClF3NO2S
    Molecular Weight 259.607
    Appearance Typically a solid
    Solubility In Water Likely insoluble due to non - polar fluorinated and aromatic groups
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Reactivity Reactive towards nucleophiles due to the presence of sulfonyl chloride group
    Odor Pungent, characteristic of sulfonyl chloride - containing compounds

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    What are the physical properties of 2- (trifluoromethyl) pyridine-5 -sulfonyl chloride?
    Nowadays, there are di- (trimethylphenyl) alkyl-5-chlorobenzyl ethers, and we want to know their physical properties. This di- (trimethylphenyl) alkyl-5-chlorobenzyl ether is mostly liquid at room temperature, and its color may be nearly colorless and transparent, or slightly light, and it can be seen as flowing.
    When it comes to odor, it often has a special smell. Although it is not pungent and intolerable, it is also different from ordinary and odorless things, and the smell can be distinguished from its uniqueness.
    Its density is slightly different compared with water, generally lighter than water. If it is placed in water, it can be seen that it floats on the water surface. The two are not miscible and the boundary is clear. In terms of solubility, in organic solvents such as ethanol and ether, it is quite soluble, just like fish get water, and the two blend seamlessly; however, in water, it is difficult to dissolve, just like oil and water, self-separating.
    Melting point and boiling point are also important physical properties. The melting point is usually in a lower temperature range, and when heated slightly, it can be easily melted into a liquid state; the boiling point is relatively high, and a certain amount of heat needs to be applied to make it boil into a gaseous state, and the physical state can be transformed within a specific temperature range.
    These physical properties are of great significance in many fields such as chemical industry and medicine. Knowing its physical properties makes it possible to make good use of it, whether for synthetic creation or for separation and purification.
    What are the chemical properties of 2- (trifluoromethyl) pyridine-5 -sulfonyl chloride
    The chemical properties of (triethylamino) ethylene-5-chloroaniline have three properties.
    First, it is alkaline. (triethylamino) part, the nitrogen atom stores solitary pairs of electrons, which can be combined with protons, and in an acidic environment, it is easy to form a cation. In case of strong acid, the nitrogen atom coordinates with the hydrogen ion to form a positively charged ion, which is a sign of its alkalinity. And due to the push-electron effect of triethyl, the electron cloud density of the nitrogen atom increases and the alkalinity is also enhanced.
    Second, the chloroaniline part, the chlorine atom has an electron-absorbing induction effect. This reduces the electron cloud density of the benzene ring, and in the electrophilic substitution reaction, the reactivity is different from that of benzene. Usually, electrophilic reagents are more difficult to attack the benzene ring, because the electron cloud density of the benzene ring decreases, and the attraction to electrophilic reagents is weakened. However, under certain conditions, such as suitable catalysts and reaction temperatures, substitution reactions can still occur, and the chlorine atom is an ortho-para-site group, and electrophilic substitution reactions mostly occur in its ortho and para-sites.
    Third, this compound contains unsaturated bonds, that is, vinyl. Vinyl has a π bond, which is active and can undergo addition reactions. Such as addition with hydrogen, in the presence of suitable catalysts such as nickel, palladium, etc., the π bond is opened and combined with hydrogen atoms to form a saturated carbon-carbon single bond; addition reactions can also occur with halogen elements, hydrogen halide, etc., depending on the reaction conditions and the proportion of reactants, different addition products can be obtained. And because of its unsaturation, it can also participate in polymerization to form polymer compounds.
    What are the main uses of 2- (trifluoromethyl) pyridine-5-sulfonyl chloride?
    (Sanxiang Jiadi) is often a help to all karma, and it is used in all things. It is involved in all things, and it is quite extensive and cannot be underestimated.
    As for it and "5-Xianyan blue alum", Xianyan blue alum, its main use is particularly important. Xianyan blue alum is mostly used in agriculture. In farming methods, blue alum is mixed with blue alum and sprinkled on the fields to prevent all kinds of pests. Insects touch it, and it is difficult to wreak havoc, protecting crops from being invisible and ensuring the hope of a bumper harvest.
    And in the dyeing and weaving industry, blue alum is also wonderfully useful. The dyer takes it to adjust the colors, help the color to be fresh and long-lasting, and not fade over time, make the fabric more delicate in color, and increase its beauty and value.
    In addition, in the way of medicine, although the dosage is prudent, it is also useful. With its characteristics, doctors can be used to treat some sores, and use it to converge and heal the skin.
    When used in combination with blue alum, if properly blended and complementary, it can help in agriculture, weaving, medicine and other industries, promote its prosperity, and bring benefits to many aspects of people's lives.
    What are the synthesis methods of 2- (trifluoromethyl) pyridine-5 -sulfonyl chloride?
    To prepare di- (triethylmethyl) heptyl-5-allyl nitrile, there are many synthesis methods, each with its own advantages and disadvantages. The following are several common methods.
    First, the reaction of halogenated hydrocarbons with metal-organic reagents is based. First, take a suitable halogenated hydrocarbon and interact with metal magnesium to make a Grignard reagent. Then, the Grignard reagent and the corresponding halogenated nitrile are co-placed under suitable reaction conditions. By nucleophilic substitution reaction, the target product can be obtained. This process requires attention to the temperature of the reaction and the choice of solvent to ensure the smooth reaction and the purity of the product. If the temperature is too high, side reactions may occur; solvent discomfort may affect the reaction rate and equilibrium. < Br >
    Second, it is achieved by allylation reaction. React with a specific cyanide-containing substrate with an allyl-containing reagent. Among them, the activity and selectivity of the allylation reagent are extremely critical. Allyl halide, allyl borate and other reagents can be selected to react with the substrate in the presence of suitable catalysts. The type and amount of catalyst have a great impact on the direction and efficiency of the reaction. For example, some transition metal catalysts, although they can accelerate the reaction, are expensive and need to be treated with caution to avoid residual metals affecting the quality of the product.
    Third, the use of carbon-carbon bonds to form reactions, such as palladium-catalyzed cross-coupling reactions. Select a suitable aryl halide or alkenyl halide, and cross-couple with a reagent containing allyl nitrile structure fragments under the action of palladium catalyst and ligand. Such reaction conditions are mild and highly selective, but palladium catalysts are expensive, and the reaction system is sensitive to impurities, so the reaction environment needs to be strictly controlled.
    Fourth, start from alaldehyde or ketone. First convert the aldehyde or ketone into the corresponding enolide or enol ether, and then react with halogenated nitrile or allyl halide. This approach requires fine regulation of the reaction steps and conditions, because the stability of enolides is limited, and various side reactions such as isomerization may occur in the reaction.
    There are various methods for the synthesis of di- (triethylmethyl) heptyl-5-allyl nitrile. In practical application, it is necessary to comprehensively consider the availability of raw materials, cost, difficulty of reaction, purity and yield of the product, and choose the optimal synthesis path.
    What should be paid attention to when storing and transporting 2- (trifluoromethyl) pyridine-5-sulfonyl chloride?
    When storing and transporting di- (triethyl) ketone and 5-thiazolidinthione, many key points need to be paid attention to.
    The first to bear the brunt, should pay attention to the regulation of temperature. These two are quite sensitive to temperature. Excessive temperature can easily cause chemical reactions or exacerbate volatilization, and too low temperature may cause solidification and other conditions, which affect their quality and performance. Therefore, when storing and transporting, it is necessary to ensure that the temperature is constant in a suitable range, usually within a specific temperature range according to its physical and chemical characteristics.
    Second, the control of humidity cannot be ignored. Humid environments can easily damp di- (triethyl) ketone and 5-thiazolidinthione, or induce adverse reactions such as hydrolysis. Therefore, a dry place should be selected for storage and transportation, and a desiccant can be used appropriately to maintain the dryness of the environment.
    Furthermore, the packaging material is extremely critical. The packaging needs to have a good seal to prevent leakage, and the material should not chemically react with the two to avoid contamination. Specific corrosion-resistant and chemical-resistant packaging materials are usually selected to ensure the safety of the product during storage and transportation.
    In addition, it is necessary to pay attention to its isolation from other substances. Di- (triethyl) ketone and 5-thiazolidinthione may react with certain substances, so when storing and transporting, they should not be stored or mixed with reactive substances such as strong oxidizers, strong acids, and strong bases.
    Finally, ventilation conditions in storage and transportation are also very important. Good ventilation can timely discharge potentially volatile gases, avoid safety hazards caused by gas accumulation, and also help to maintain suitable environmental conditions.
    Storage and transportation of di- (triethyl) ketone and 5-thiazolidinthione require comprehensive consideration of temperature, humidity, packaging, isolation, and ventilation to ensure their quality and safety.