2 Trifluoromethyl Pyridine 4 Carbaldehyde
pyridine pyrrole pyrazine piperidine piperazine

2-(trifluoromethyl)pyridine-4-carbaldehyde

    Specifications

    HS Code

    319381

    Chemical Formula C7H4F3NO
    Molecular Weight 175.11
    Appearance Typically a solid or liquid, color may vary
    Boiling Point Data may vary, usually in a specific temperature range related to its molecular structure
    Melting Point Data may vary, characteristic for the compound
    Solubility Solubility properties in common solvents like organic solvents, may be sparingly soluble in water
    Density Specific value based on its mass - volume relationship
    Vapor Pressure Related to its volatility, value depends on temperature
    Flash Point Important for fire - hazard assessment, specific value
    Pka Relevant for its acidic - basic properties in solution, specific value

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    General Information
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    Frequently Asked Questions

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    What are the main uses of 2- (trifluoromethyl) pyridine-4-formaldehyde?
    Di- (triethyl) pentane and 4-ethylheptane are both alkanes in organic compounds. Their main uses are in the field of fuels.
    Alkanes are rich in hydrocarbons and have a hot topic value. Combustion can release a lot of heat energy. Such as gasoline, diesel, kerosene and other fuels, mostly contain such alkanes. Vehicles, ships, airplanes and other transportation vehicles rely on their combustion for energy, so that the engine runs and provides power. Industrial boilers, civil heating, etc. also commonly use fuels containing such alkanes to meet the needs of producing domestic heat energy.
    Furthermore, they are of great significance in the field of organic synthesis. They are basic raw materials and can be converted into various organic compounds through a series of chemical reactions. Such as through cracking reaction, olefin is produced, and olefin is the key monomer for the synthesis of important organic polymer materials such as plastics, rubber, fibers, etc. By halogenation reaction, halogenated hydrocarbons can be prepared, and halogenated hydrocarbons are widely used in medicine, pesticides, solvents and other fields.
    In addition, in the preparation of lubricating oils and greases, such alkanes can be used as base oils. Because of its suitable viscosity, good thermal stability and oxidation stability, it can form a protective film on the surface of mechanical parts, reduce friction and wear, ensure the smooth and efficient operation of machinery, and prolong the service life.
    In the field of chemical research and analysis, they are used as standard materials for the calibration and qualitative and quantitative analysis of gas chromatography, liquid chromatography and other analytical methods, helping researchers to accurately determine the structure and content of other compounds.
    What are the physical properties of 2- (trifluoromethyl) pyridine-4-formaldehyde?
    Triethylamine is a colorless and transparent liquid with the smell of ammonia. Its boiling point is about 89.5 ° C, melting point is -114.8 ° C, relative density is 0.726 (20/4 ° C), and it is soluble in water, ethanol, ether and other solvents. This substance is flammable and has the risk of explosion in case of open flame and hot topic. Its vapor and air can form explosive mixtures.
    And 4-methyl pyridine, also a colorless to light yellow liquid, has a special odor. Its boiling point is about 145 ° C, melting point is -63.2 ° C, and relative density is 0.95 (20/4 ° C). 4-methyl pyridine is soluble in common solvents such as water, ethanol, and ether. This substance is also flammable. When its vapor mixes with air, it can form an explosive mixture. In case of open flame and high heat energy, it can cause combustion and explosion. At the same time, its vapor is heavier than air and can spread at a lower place to a considerable distance. In case of fire, it will ignite and backfire.
    Both are organic compounds. In terms of chemical properties, they are both alkaline and can react with acids to form salts. In the industrial field, triethylamine is often used as a solvent, catalyst and intermediate in organic synthesis; 4-methylpyridine is mostly used as a raw material for the synthesis of medicines, pesticides, dyes, etc. When using and storing both, it is necessary to pay attention to safety measures such as fire prevention, explosion prevention, and anti-virus, as they can irritate the human respiratory tract, eyes, and skin. Excessive inhalation or exposure may cause damage to health.
    What are the chemical properties of 2- (trifluoromethyl) pyridine-4-formaldehyde?
    Triethylamine and 4-ethoxybenzaldehyde are both organic compounds, and their chemical properties have their own characteristics, which are described in detail below.
    Triethylamine is an alkaline organic base. Its nitrogen atom has lone pair electrons and can accept protons, so it is alkaline. This characteristic makes it often used as an acid binding agent in the field of organic synthesis, used to neutralize the acid generated by the reaction and push the reaction forward. For example, in esterification reactions, triethylamine can bind to the generated carboxylic acid to prevent the acid from inhibiting the reaction. Furthermore, triethylamine can be used as a nucleophilic reagent to participate in nucleophilic substitution reactions. Because the lone pair electrons of nitrogen atoms are nucleophilic, they can attack electrophilic reagents, such as halogenated hydrocarbons, to form new chemical bonds.
    As for 4-ethoxybenzaldehyde, the aldehyde group is its key functional group, giving it significant chemical activity. 4-ethoxybenzaldehyde can be oxidized, and the aldehyde group can be oxidized to a carboxyl group. Commonly used oxidants, such as potassium permanganate, silver ammonia solution, etc., can contribute to this reaction. In addition, 4-ethoxybenzaldehyde can participate in the condensation reaction. The carbon-oxygen double bond of the aldehyde group is electrophilic, and it is easy to condensate with compounds containing active hydrogen, such as amines and alcohols. Under basic conditions, 4-ethoxybenzaldehyde reacts with amines to form Schiff base. Moreover, the ethoxy group of 4-ethoxybenzaldehyde is affected by the benzene ring, and it also has certain activity. Under specific conditions, substitution reactions may occur.
    In summary, triethylamine is mainly basic and nucleophilic, while 4-ethoxybenzaldehyde is mainly characterized by oxidation and condensation of aldehyde groups. The two play different and important roles in organic chemical reactions.
    What are the synthesis methods of 2- (trifluoromethyl) pyridine-4-formaldehyde?
    To prepare di- (triethylmethyl) heptyl-4-enonitrile, the following methods can be used:
    First, the nucleophilic substitution reaction of halogenated hydrocarbons and nitriles is used. Select an appropriate halogenated hydrocarbon, such as a halogenated alkane containing a triethylmethyl structure, and make it react with nitrile reagents such as sodium cyanide or potassium cyanide in a suitable solvent, such as dimethyl sulfoxide (DMSO) or N, N-dimethyl formamide (DMF), at a certain temperature. This reaction relies on the activity of halogen atoms in halogenated hydrocarbons, the nucleophilic attack of nitrile negative ions, and the substitution of halogens to obtain the target product. However, it is necessary to pay attention to the activity and selectivity of halogenated hydrocarbons, and beware of side reactions, such as elimination reactions.
    Second, it is prepared by the addition reaction of olefins. First, the olefin containing triethyl is prepared, and then it is added with hydrogen cyanide (HCN) in the presence of a catalyst. The commonly used catalyst can be transition metal complexes, such as nickel and palladium complexes. In this process, the double bond of the olefin is opened, and the cyanyl group and hydrogen atoms are added to the carbon atoms at both ends of the double bond to form the target alkenonitrile product. However, hydrogen cyanide is highly toxic, and the operation must be carried out with caution under good ventilation and safety protection conditions.
    Third, the synthesis of organometallic reagents. Such as preparing Grignard reagents containing triethyl methyl or organolithium reagents, so that it reacts with nitrile compounds. Taking Grignard reagents as an example, halogenated hydrocarbons and magnesium react in anhydrous ether or tetrahydrofuran to obtain Grignard reagents, and then react with alkenyl-containing nitriles to construct the target molecular structure through a nucleophilic addition process. This method requires strict anhydrous and anaerobic conditions to ensure the activity and stability of organometallic reagents.
    What are the precautions for the storage and transportation of 2- (trifluoromethyl) pyridine-4-formaldehyde?
    There are three things that need to be paid attention to when it is transported in Tibet.
    First, the place to hide must be a dry, cool and well-ventilated place. Sanxiang methyl is sensitive, and if it is in a humid and warm place, it is easy to deteriorate. Those who used to handle this thing in the past put it in a damp and humid place. Not long after, the color changes, the taste is also different, and the effect is greatly reduced. Sijia sharks are also not heat-resistant. Under high temperatures, their quality is gradually damaged and their medicinal power is gradually lost. Therefore, when they are hidden, they must ensure that the environment is suitable to preserve their quality.
    Second, when they are transported, the packaging must be strict. Sanxiang methyl is volatile. If the packaging is omitted and escapes from the outside, it will not only damage itself, but also cause the surrounding objects to be stained by it. Although the four-armor shark is not volatile, its quality is brittle. If the packaging is not solid, it will be bumpy during transportation and easy to break. Those who try to transport the four-armor shark with simple clothes will encounter bumps in the way, and more than half of the shark will be broken and damaged, which is greatly useless. It is necessary to have a strong and dense packaging.
    Third, those who handle it must know its nature. Sanxiang methyl is toxic. When handling, you must prepare protective equipment, such as gloves, masks, etc., so as not to touch or enter the body. Although Sijia sharks are non-toxic, their ingredients may repel other things, so be cautious when mixing. Some people have been unsure of the properties of Sijia sharks, and they were mismatched with other medicines, causing adverse reactions. Therefore, the operator must understand the pharmacology of physical properties before they can be correct.
    Tibet transports Sanxiang methyl and Sijia sharks, pay attention to these things, so that you can keep their quality and make the best use.