2-(trifluoromethyl)pyridine-3-carbonitrile

What is the main use of trimethyl ether?
Trimethyl ether, also known as dimethyl ether, is used in various fields. In the field of medicine, it is often used as an anesthetic. It is volatile and can enter the body through the respiratory tract, causing the patient's central nervous system to be suppressed, causing pain to disappear, the body to relax, and the operation to be carried out smoothly. Because of its good anesthetic efficacy, short induction period, quick recovery, and relatively few side effects, it is commonly used in clinical anesthesia.
In the chemical industry, it is an important organic solvent. Because of its good solubility, it can dissolve many organic compounds, such as resins, rubbers, oils, etc. In the production of coatings, inks, adhesives, etc., it is often used to dissolve resins, reduce their viscosity, and facilitate coating and construction. And its volatility is moderate, and after the solvent evaporates, the coating or adhesive layer can be quickly dried and cured.
In the field of organic synthesis, it is also a common raw material and intermediate. Through specific chemical reactions, groups such as methyl groups can be introduced to synthesize complex organic compounds. For example, in the synthesis of certain drugs, fragrances, and pesticides, trimethyl ether is used as the starting material or intermediate, and the structure of the target molecule is constructed through a series of reactions.
In addition, in scientific research experiments, it is also often used as a reaction medium or extractant. Due to its stable physical and chemical properties, it does not interfere with many reactions, and can provide a suitable reaction environment to help the reaction proceed smoothly. And because it is immiscible with water and some organic solvents, it can be used for the extraction and separation of mixtures to obtain desired compounds.

To prepare di- (triethylmethyl) propane-3-acetaldehyde, the method is as follows:
First, the isobutyraldehyde and formaldehyde are used as raw materials, and they are prepared by the condensation reaction of hydroxyaldehyde. In an alkaline environment, isobutyraldehyde is acidic and can be dissociated into anion. This anion nucleophilic attacks the carbonyl carbon of formaldehyde to form a β-hydroxyaldehyde intermediate. Subsequently, a dehydration reaction occurs when heated, and the hydroxyl group and the hydrogen on the adjacent carbon atom dehydrate a molecule of water to form an unsaturated aldehyde, namely di- (triethylmethyl) acronaldehyde. After catalytic hydrogenation, the carbon-carbon double bond and aldehyde group are reduced to obtain the target product di- (triethyl) propane-3-acetaldehyde.
Second, react with metal-organic reagents with suitable halogenated hydrocarbons. Halogenated hydrocarbons containing the target carbon skeleton can be prepared first. For example, select a halogenated alkane with appropriate halogen atom substitution and make a Grignard reagent with metal magnesium. The Grignard reagent has strong nucleophilic properties and reacts with the corresponding carbonyl compound (such as a suitable aldehyde or ketone) to form a carbon-carbon bond and introduce the desired substituent. Subsequent steps such as hydrolysis convert the intermediate product to di- (triethyl) propane-3-acetaldehyde.
Third, the synthesis method of diethyl malonate is used. Diethyl malonate has active methylene. Under alkaline conditions, the hydrogen of methylene is taken away by the base to form carbon negative ions. This carbon negative ion undergoes a nucleophilic substitution reaction with halogenated hydrocarbons containing the desired substituents, and a substituent is introduced. After a series of reactions such as hydrolysis and decarboxylation, the carbon skeleton of the target molecule is constructed, and finally di- (triethyl) propane-3-acetaldehyde can be obtained.
All synthesis methods have advantages and disadvantages, and the appropriate method must be selected according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product.

Trialkyl methyl is also a chemical substance. It has unique properties and is a group commonly used in organic synthesis.
As for the physical properties of trialkyl methyl, it is mostly stable. At room temperature, it is mostly liquid or solid, depending on the structure and relative mass of its molecules. Its boiling point and melting point are also determined by the forces between molecules. If the intermolecular force is strong, the boiling point is high; otherwise, it is low.
In addition, trialkyl methyl, its solubility is also an important physical property. It is mostly soluble in organic solvents, such as ethers and hydrocarbons. Due to the principle of "similarity and compatibility", organic solvents and trialkyl methyl have similar structures, so they are soluble. < Br >
And ethane is a genus of alkanes. It is a colorless and odorless gas, which is its intuitive physical property. Its density is slightly smaller than that of air, because the relative molecular weight is smaller than the average relative molecular weight of air.
The melting boiling point of ethane is low. Under normal pressure, the melting point is -183.3 ° C and the boiling point is -88.6 ° C. This is because the intermolecular force of ethane is van der Waals force, which is weak, so the melting boiling point is not high.
Ethane is slightly soluble in water, but soluble in many organic solvents. This is also because of "similar miscibility". Water is a polar molecule, while ethane is a non-polar molecule, and the structure difference between the two is large, so it is difficult to dissolve; organic solvents are mostly non-polar or weakly polar, and are similar to ethane, so they are soluble.
In summary, the physical properties of trialkyl methyl and ethane are different, and they both play an important role in the field of chemistry and are the key to research and application.

(Triethylmethyl) pentane and 3-methylheptane are both organic compounds, and their chemical properties are common to hydrocarbons.
First, both are flammable. In sufficient oxygen, it can burn violently to generate carbon dioxide and water. For example, the reaction of (triethylmethyl) pentane combustion can be roughly expressed as\ (C_ {12} H_ {26} + 18.5O_ {2}\ stackrel {ignited }{=\!=\!=} 12CO_ {2} + 13H_ {2} O\); 3-methylheptane combustion reaction is about\ (C_ {8} H_ {18} + 5O_ {2}\ stackrel {ignited }{=\!=\! =} 8CO_ {2} + 9H_ {2} O\). This combustion reaction is a common oxidation reaction of hydrocarbons and is often used as a fuel to release energy.
Second, the substitution reaction can occur. Under light or specific catalyst conditions, hydrogen atoms in molecules can be replaced by halogen atoms. For example, taking chlorine gas as an example, hydrogen atoms in (triethylmethyl) pentane molecules can be gradually replaced by chlorine atoms to generate various products such as chlorine (triethylmethyl) pentane; the same is true for 3-methyl heptane. Under light and chlorine gas, hydrogen atoms are replaced by chlorine atoms to form 3-methyl heptane derivatives with different degrees of chlorination. This substitution reaction is an important way to introduce halogen atoms in organic synthesis.
Third, the chemical properties of the two are relatively stable. Under normal temperature and pressure without special conditions, there is generally no significant reaction with strong acids, strong bases, strong oxidants, etc. Because of its relatively strong carbon-carbon single bond and carbon-hydrogen bond, specific conditions are required to break, which makes them stable in general environments and easy to store and transport.
In summary, (triethylmethyl) pentane and 3-methyl heptane, as alkane compounds, have flammability, substitution reaction and other chemical properties, and are relatively stable at room temperature. These properties are widely used in the field of organic chemistry.

Trialkyl methyl, and trimethylheptane, in storage and transportation, many precautions should not be ignored.
When storing, the first choice of environment. It needs to be placed in a cool and ventilated warehouse, away from fire and heat sources, because both are flammable, and it is easy to cause combustion and explosion in case of open flame and hot topic. The temperature of the warehouse should be strictly controlled, not too high, to prevent changes in material properties. And it should be stored separately from oxidants and acids to avoid mixed storage, because these substances come into contact with it, or cause violent chemical reactions, causing accidents.
Furthermore, the material and sealing of the storage container are crucial. Containers of suitable materials must be used to ensure that they can withstand the corrosion of the stored substances and have good sealing to prevent leakage. Periodically check the storage equipment and containers to see if there is any damage or leakage. Once found, deal with it immediately.
When transporting, there are also many precautions. The transport vehicle must meet safety standards and be equipped with corresponding fire equipment and leakage emergency treatment equipment. When loading, it must be stable to prevent the container from being damaged due to bumps and collisions during transportation. Transport personnel also need to be professionally trained and familiar with the dangerous characteristics of the transported substances and emergency disposal methods. Transportation route planning should not be ignored. Sensitive areas such as water sources and densely populated areas should be avoided to prevent leakage from causing serious harm to the environment and people.
When driving on the way, it is necessary to drive slowly and steadily to avoid intense operations such as sudden braking and sharp turns. And the transportation process needs to be supervised throughout the process, and the transportation status should be kept under control at any time. If there is any abnormality, respond immediately and take appropriate measures to ensure the safety of storage and transportation.