2-Trifluoromethyl-pyridine-3-carbaldehyde

2-Trifluoromethyl-pyridine-3-formaldehyde is also a key intermediate in organic synthesis. It has a wide range of uses and is of great significance in many fields.
In the field of medicinal chemistry, it is often the cornerstone of the creation of new drugs. Due to its unique chemical structure, it can endow drugs with specific biological activities. Such as participating in the synthesis of drug molecules with antibacterial, antiviral and even anti-tumor effects. Taking the development of a new type of antibacterial drug as an example, this compound can be ingeniously chemically modified to access specific functional groups, so as to precisely regulate the interaction between drugs and bacterial targets, enhance antibacterial efficacy, and reduce the adverse effects on human normal cells, making significant contributions to human health and well-being.
In the field of materials science, 2-trifluoromethyl-pyridine-3-formaldehyde also has outstanding performance. It can be used to prepare organic materials with special properties, such as optoelectronic materials. Due to the presence of trifluoromethyl in its structure, it can significantly affect the electron cloud distribution of the material, thereby improving the optical and electrical properties of the material. With this, materials that perform well in optoelectronic devices such as organic Light Emitting Diode (OLED) can be synthesized, which can improve the luminous efficiency, stability and color purity of the device, and promote the progress of display technology.
In addition, in the field of pesticide chemistry, it also plays an important role. It can be used as a key raw material for the synthesis of high-efficiency and low-toxicity pesticides. Through rational molecular design and synthesis, pesticides can be highly selective to target pests or weeds, which can not only effectively control the growth of pests and weeds, ensure the yield and quality of crops, but also reduce environmental pollution and ecological balance damage, and meet the needs of today's green agriculture development.
In summary, 2-trifluoromethyl-pyridine-3-formaldehyde is an indispensable and important compound in many fields such as medicine, materials, and pesticides, and plays a key role in promoting the development and progress of various fields.

The synthesis method of 2-trifluoromethyl-pyridine-3-formaldehyde, although the ancient book "Tiangong Kaiwu" did not directly record the synthesis of this specific compound, it can be deduced by ancient chemical process concepts and modern chemical knowledge.
First, pyridine is used as the starting material. Pyridine has an aromatic ring structure and can take advantage of its electrophilic substitution reaction characteristics. First, the pyridine is modified with appropriate positioning groups to guide the reaction to occur at a specific position. For the introduction of aldehyde groups at the 3-position of pyridine, please refer to the classic Vilsmeier-Haack reaction. N, N-dimethylformamide (DMF) is mixed with phosphorus oxychloride (POCl) to form an active formylation reagent. When reacted with pyridine, an aldehyde group can be introduced at the 3-position to generate 3-pyridine formaldehyde.
However, the target product needs to introduce trifluoromethyl at the 2-position of pyridine. At this time, a follow-up reaction can be carried out on 3-pyridine formaldehyde. Using a halogenation reaction, a halogen atom is introduced at the 2-position, such as 2-bromo-3-pyridine formaldehyde obtained by bromination. After that, the nucleophilic substitution reaction with 2-bromo-3-pyridine formaldehyde can be carried out with a trifluoromethylation reagent, such as trifluoromethyl copper lithium reagent (CF-CuLi), by means of metal-organic chemical methods, so that the trifluoromethyl substitutes the bromine atom, so as to obtain 2-trifluoromethyl-pyridine-3-formaldehyde.
Second, suitable pyridine derivatives containing trifluoromethyl can also be used as starting materials. If there is 2-trifluoromethylpyridine, an aldehyde group can be introduced at the 3-position by selective oxidation. A mild oxidizing agent, such as selenium dioxide (SeO _ 2), can be selected to oxidize 2-trifluoromethyl pyridine under appropriate solvent and reaction conditions, selectively oxidize the active hydrogen at the 3-position to form an aldehyde group, and then obtain the target product 2-trifluoromethyl-pyridine-3-formaldehyde. Both methods require fine control of reaction conditions, consideration of reagent dosage, reaction temperature, time and other factors, in order to achieve the purpose of efficient synthesis of the target product.

2-Trifluoromethylpyridine-3-formaldehyde, this substance is colorless to light yellow liquid, clear and translucent in appearance, without obvious impurities mixed in it. Its smell is unique, slightly irritating, and under the fine smell, there is a special smell similar to pyridine, but due to the introduction of trifluoromethyl, it adds a bit of a different flavor.
In terms of its boiling point, it is about 110-112 ° C. At this temperature, the substance gradually changes from liquid to gaseous state, which is crucial in the experimental operation of separation, purification and industrial production process. Its melting point is relatively low, about -10 ° C, which makes it stable in liquid form at room temperature.
In terms of solubility, 2-trifluoromethyl pyridine-3-formaldehyde is soluble in a variety of organic solvents, such as common ethanol, ether, dichloromethane, etc. In ethanol, it can quickly blend with ethanol molecules to form a uniform and stable solution. However, its solubility in water is poor. Due to the strong hydrophobic group in the molecular structure, the ability of the substance to interact with water molecules is greatly reduced, making it difficult to dissolve in water.
The density of this compound is about 1.35g/cm ³, which is higher than that of water. If it is placed in the same container with water, the compound will sink to the bottom of the water. This density characteristic is also an important consideration when it comes to practical operations such as liquid-liquid separation.
At the level of chemical stability, although 2-trifluoromethylpyridine-3-formaldehyde is relatively stable, it has certain activity due to the presence of aldehyde groups. In case of strong oxidants, aldehyde groups are easily oxidized to carboxyl groups; in case of nucleophiles, the carbon and oxygen double bonds of aldehyde groups are vulnerable to attack, and nucleophilic addition reactions occur. And because of the strong electron-absorbing effect of trifluoromethyl, the electron cloud density on the pyridine ring decreases, which in turn affects the reactivity of the pyridine ring, so that in the electrophilic substitution reaction, the reaction conditions are slightly different from those of ordinary pyridine derivatives.

2-Trifluoromethyl-pyridine-3-formaldehyde is one of the organic compounds. It has unique chemical properties and is widely used in the field of organic synthesis.
First of all, its physical properties, this substance is liquid at room temperature and pressure, with a specific boiling point and melting point, but the exact value should be subject to experimental determination. Because its molecule contains trifluoromethyl, it has a certain lipid solubility and good solubility in organic solvents, such as common ether, dichloromethane, etc., but poor solubility in water.
In terms of chemical properties, aldehyde groups are active functional groups, prone to oxidation reactions, and can be oxidized to corresponding carboxylic acids. In case of strong oxidants, such as potassium permanganate, the aldehyde group can be oxidized to a carboxyl group to form 2-trifluoromethyl-pyridine-3-carboxylic acid. Reduction reactions can also occur. Treated with reducing agents such as sodium borohydride, the aldehyde group can be reduced to alcohol hydroxyl groups to obtain 2-trifluoromethyl-pyridine-3-methanol.
In addition, aldehyde groups can undergo nucleophilic addition reactions with compounds containing active hydrogen. If catalyzed with alcohols under acid catalysis, acetals can be formed, which are often used to protect aldehyde groups in organic synthesis. Condensation reactions can occur with ammonia and its derivatives, such as hydroxylamine, hydrazine, etc., to form products such as oxime and hydrazone.
Furthermore, the pyridine ring is aromatic, and the electron cloud density distribution on the ring is uneven, which can occur electrophilic substitution reaction. Because trifluoromethyl is a strong electron-absorbing group, the electron cloud density of the pyridine ring is reduced, and the electrophilic substitution reaction activity is weaker than that of the pyridine itself. Substitution reactions mostly occur in positions with relatively high electron cloud density of the pyridine ring.
2-trifluoromethyl-pyridine-3-formaldehyde has active chemical properties and is an important intermediate in organic synthesis, pharmaceutical chemistry and other fields. With its reaction characteristics of aldehyde groups and pyridine rings, various organic compound structures can be constructed.

In today's world, it is not easy to know the price range of 2-trifluoromethyl-pyridine-3-formaldehyde in the market. Due to the complex market conditions, its price often changes for many reasons.
In the past, the price of materials often depended on the situation of supply and demand. If there are many people who want this thing, and there are few people who supply it, the price will increase; on the contrary, if the supply exceeds the demand, the price may drop. And the difficulty of its preparation and the price of the raw materials used also affect its price.
The price of raw materials is related to the luck of heaven and earth, or natural and man-made disasters, which cause the production to decrease and price to rise, which affects the cost of 2-trifluoromethyl-pyridine-3-formaldehyde, and then the selling price. Preparation technology is also a major factor. If the new technology is developed, the yield increases and the wear and tear decreases, the price may decline; if the technology is stagnant, the cost is difficult to cut, and the price may remain high.
And the regional differences in the market also make the price different. In remote lands, due to the cost of transportation, the difference between supply and demand, the price may be different from that of Tongdu Dayi. Furthermore, the strategies of merchants, either for market competition or for profit, have their own ways of pricing.
Although it is difficult to determine the range of its price, looking at the examples of various chemical materials in the past, if this material is not rare, its price per kilogram or in the hundreds to thousands of yuan in the ordinary market. However, this is only an idea. To obtain a price, you need to consult the chemical market, merchants or related companies to obtain a real-time price.