2 Trifluoromethyl 5 Chloromethyl Pyridine
pyridine pyrrole pyrazine piperidine piperazine

2-(trifluoromethyl)-5-chloromethyl pyridine

    Specifications

    HS Code

    611695

    Chemical Formula C7H5ClF3N
    Molecular Weight 195.57
    Appearance Typically a colorless to light - yellow liquid or solid (varies based on purity and conditions)
    Melting Point Data may vary, needs specific experimental determination
    Boiling Point Data may vary, needs specific experimental determination
    Solubility In Water Low solubility in water due to non - polar fluoromethyl and pyridine groups
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, etc.
    Density Data may vary, needs specific experimental determination
    Vapor Pressure Relatively low vapor pressure, influenced by temperature
    Flash Point Data may vary, needs specific experimental determination
    Pka Data may vary depending on the environment, relevant for its acidic - basic properties in solution

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    Frequently Asked Questions

    As a leading 2-(trifluoromethyl)-5-chloromethyl pyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2- (trifluoromethyl) -5-chloromethylpyridine?
    2-% (triethyl) - 5-chloromethylpyridine, this substance has a wide range of uses. In the field of medicine, it can be used as a key intermediate to help synthesize a variety of drugs. For example, in the preparation of some antibacterial drugs, 2-% (triethyl) - 5-chloromethylpyridine can build a drug active structure through specific reaction steps, laying the foundation for antibacterial efficacy.
    In terms of pesticides, it is also an important raw material. With the help of chemical transformation, pesticide products with high insecticidal and herbicidal properties can be prepared. Like some new insecticides, this is used as a starting material to generate active ingredients through multi-step reactions, which have significant killing effects on specific pests and escort agricultural production.
    In the field of materials science, 2-% (triethylmethyl) -5-chloromethylpyridine can participate in the synthesis of functional materials. For example, when synthesizing some polymer materials with special optical and electrical properties, it can be used as a functional monomer, endowing materials with unique properties, expanding material application scenarios, and playing a role in electronic devices, optical instruments and other fields.
    In addition, it is often used as an important reagent in the study of organic synthetic chemistry. Due to its unique chemical structure, it can participate in various organic reactions, providing an effective way for the synthesis of complex organic compounds, promoting the development of organic synthetic chemistry, and helping researchers explore more novel compounds and their potential applications.
    What are the synthesis methods of 2- (trifluoromethyl) -5-chloromethylpyridine?
    In order to prepare 2 - (triethyl) -5 - bromobenzyl, there are many ways to synthesize it, and the main ones are selected as follows.
    First, benzyl halide is used as the starting material. Benzyl halide and triethyl metal reagent can undergo nucleophilic substitution reaction under suitable reaction conditions. For example, benzyl bromide and triethylaluminum, in an anhydrous, oxygen-free and low temperature environment, in a suitable organic solvent, such as anhydrous ethyl ether or tetrahydrofuran, the carbon anion of ethyl in triethylaluminum acts as a nucleophilic reagent to attack the carbon atom connected to the halogen atom in benzyl bromide, and the halogen atom leaves, so 2 - (triethyl) intermediate is obtained. Then, the intermediate is reacted with a brominating reagent, such as N-bromosuccinimide (NBS), in an inert solvent under the presence of light or an initiator. The hydrogen atom at the benzyl position is replaced by the bromine atom, and the target product 2 - (triethyl) -5 -bromobenzyl can be obtained.
    Second, benzaldehyde derivatives are used as starting materials. First, benzaldehyde is reacted with triethylphosphine Yellide. This reaction condition is relatively mild and can occur at room temperature or slightly heated in common organic solvents. The carbonyl group of benzaldehyde undergoes a nucleophilic addition-elimination reaction with phosphine ylide to form a carbon-carbon double bond to form a 2- (triethyl) styrene compound. Then, the compound is brominated, and bromine can be used in a suitable catalyst, such as iron powder or iron tribromide, to replace the hydrogen atom on the benzene ring. By controlling the reaction conditions and the proportion of the reactants, the bromine atom can be selectively substituted in the target position to obtain 2- (triethyl) -5 -bromobenzyl.
    Third, it can also be started from aromatic hydrocarbons. Aromatic hydrocarbons are first combined with triethylation reagents, such as triethyl boron, under the catalysis of transition metal catalysts such as palladium catalysts, carbon-carbon bond coupling reaction is carried out, and triethyl groups are introduced. Subsequently, the obtained product is brominated. This bromination step can select suitable bromination methods and conditions according to different reactivity and positioning rules, and finally achieve the synthesis of 2 - (triethyl) - 5 - bromobenzyl.
    What are the physical properties of 2- (trifluoromethyl) -5-chloromethylpyridine?
    For 2-% (triethyl) -5-bromoethylbenzene, its physical properties can be investigated. The external appearance of this compound is often liquid, and in the environment of the room, it is more fluid, and it can be felt that it is slippery. Its color is often nearly transparent to the color, or slightly light, but it is not deep and clear.
    Its taste is also special, and it often spreads a special fragrance. This fragrance is not pungent, but a soft and specific taste. However, different people may have different feelings due to the sensitivity of the smell.
    As for the boiling temperature, due to the characteristics of molecular temperature and molecular force, the melting temperature is low, often in the low temperature region, and it is liquid in the ordinary environment. And the boiling temperature is high, and a certain amount needs to be added to make it boil and melt.
    In terms of solubility, this substance has good solubility in the solution, such as ethanol, ether, etc., which can be mutually soluble to form a homogeneous mixture. However, in water, its solubility is very small, and its molecular solubility is very different from that of water, so it is soluble in water.
    Density is also one of its physical properties. Its density is slightly higher than that of water. If it is mixed with water, the substance will sink to the bottom of the water, which can be used to identify this property.
    In addition, the refractive index of this compound also has a specific value. If light passes through this object, the direction of light propagation will generate a certain degree of deflection. The value of this refractive index is its inherent physical properties and can be used as one of the dependencies of this substance.
    What are the market prospects for 2- (trifluoromethyl) -5-chloromethylpyridine?
    The market prospect of Guanfu di- (Sanxiangmethyl) -5-chloromethylpyridine is really the focus of attention in the business industry.
    Today, this compound shows extraordinary potential in many fields. In the pharmaceutical industry, due to its unique chemical structure, it may become a key intermediate for the development of new drugs. As people pay more and more attention to health, the pharmaceutical market continues to expand, and the demand for various effective drugs is increasing. If new drugs with significant efficacy are developed based on this, their market share may be immeasurable.
    In the agricultural field, with the development of green agriculture and precision agriculture, the demand for high-efficiency and low-toxicity pesticides is increasing day by day. The chemical properties of di- (Sanxiangmethyl) -5-chloromethylpyridine may help to develop more ideal pesticide products, which can not only effectively control pests and diseases, but also reduce the harm to the environment. In this way, in line with the current trend of agricultural development, it is also expected to occupy an important place in the agricultural chemical market.
    Looking at the chemical industry, as an important raw material for organic synthesis, it can derive a variety of high value-added products. With the continuous innovation of chemical industry technology, the quality and performance requirements of basic raw materials are also increasing. If di- (Sanxiangmethyl) -5-chloromethylpyridine can be guaranteed in terms of quality and supply stability, it will surely win a broad market space in the chemical industry chain.
    However, although the market opportunities are abundant, there are also challenges. First, the optimization of production technology and cost control are very critical. Only by continuously improving the production process and reducing production costs can we stand out in the fierce market competition. Second, environmental protection regulations are becoming increasingly stringent, and the production process must strictly follow relevant standards to ensure that the impact on the environment is minimized.
    In summary, the market prospect of di- (Sanxiang methyl) -5-chloromethylpyridine is promising, but practitioners need to gain insight into market changes, overcome technical problems, and comply with regulatory requirements in order to seize business opportunities and gallop to the business sea.
    What should be paid attention to when storing and transporting 2- (trifluoromethyl) -5-chloromethylpyridine?
    Fudi- (trichloromethyl) -5 -bromomethyl pyridine, when storing and transporting, pay attention to many matters.
    The first thing to pay attention to is its chemical properties. This substance has specific chemical activity, and when storing, it is necessary to avoid contact with chemicals such as strong oxidants and strong bases. Covering strong oxidants can lead to violent oxidation reactions, causing the risk of explosion; strong bases interact with it, or change the chemical structure, damage its quality, or even cause accidental reactions.
    Times and environmental conditions. Store in a cool, dry and well-ventilated place. Cool can prevent the evaporation of substances and the increase of reactivity due to excessive temperature; dry can avoid moisture hydrolysis, etc., and unpredictable reactions may occur due to water; good ventilation can disperse harmful gases that may leak in time to avoid accumulation.
    Furthermore, it is related to the packaging. The packaging must be tight and suitable. It is necessary to use materials that can withstand its chemical corrosion, such as specific plastic, glass or metal containers, and ensure that there is no leakage. When transporting, the packaging should also be reinforced to prevent package damage and leakage due to bumps and collisions.
    The mode of transportation should also be carefully selected. According to its dangerous characteristics, the means of transportation and the process of compliance should be selected. If transported by land, the transport vehicle must have corresponding protective and emergency equipment; shipping must follow maritime safety regulations to ensure transportation safety.
    Personnel operation is also critical. Personnel involved in storage and transportation, when professionally trained, are familiar with the characteristics of the substance, hazards and emergency treatment methods. When operating, it is necessary to adapt protective equipment, such as protective clothing, gloves, goggles, etc., to ensure their own safety.