2-(tert-butyloxycarbonyl)-aminopyridine-5-carboxaldehyde

To prepare 2 - (tert-butoxycarbonyl) aminopyridine-5-formaldehyde, the method is as follows:
First, a suitable pyridine derivative is taken as the starting material. This material needs to have a modifiable group at a specific position of the pyridine ring to facilitate subsequent reactions. The amino group is first protected, and the tert-butoxycarbonyl (Boc) protecting group is commonly used. Using di-tert-butyl dicarbonate (Boc -2 O) as the reagent for introducing Boc, in a suitable solvent, such as dichloromethane, N, N-dimethylformamide (DMF), add an organic base, such as triethylamine, N, N-diisopropylethylamine (DIPEA), and adjust to a suitable alkaline environment. The alkali can assist in the isocleavage of di-tert-butyl dicarbonate to form an active intermediate, which is substituted with the amino nucleophilic of the pyridine derivative to form a 2- (tert-butoxycarbonyl) aminopyridine derivative. This step requires temperature control, generally between 0 ° C and room temperature. When the reaction number is monitored by thin layer chromatography (TLC), until the raw material point disappears into the reaction, and then purified by extraction, column chromatography, etc.
Then the pyridine derivative that has protected the amino group is converted into an aldehyde group. It can be reacted by Vilsmeier-Haack reaction. Mixing N, N-dimethylformamide (DMF) with phosphorus oxychloride (POCl 🥰), the solution containing the substrate is slowly added dropwise at low temperature. DMF and POCl 🥰 act to form an electrophilic Wilsmeier reagent, attacking the specific position of the pyridine ring to form an intermediate. After hydrolysis, the aldehyde group is present. The hydrolysis step requires careful control of the reaction conditions to prevent by-products from being generated due to overreaction. After the reaction, a series of operations such as neutralization, extraction, drying, and column chromatography can obtain pure 2- (tert-butoxycarbonyl) aminopyridine-5-formaldehyde. In the
preparation process, it is extremely important to control the reaction conditions at each step, such as temperature, reagent ratio, reaction time, etc., all of which are related to the yield and purity of the product.

2-%28tert+-+butyloxycarbonyl%29-aminopyridine-5-carboxaldehyde is 2- (tert-butoxycarbonyl) aminopyridine-5-formaldehyde. The physical properties of this substance are worth exploring.
It is mostly solid at room temperature and pressure. Looking at its appearance, it is often white to off-white crystalline powder, which is easy to distinguish intuitively. Its melting point is also one of the important physical properties. After many experiments, the melting point is roughly within a specific range. This melting point characteristic is crucial for identifying the substance and controlling its purity.
Furthermore, the solubility of this substance also has its characteristics. In common organic solvents, such as dichloromethane, chloroform, etc., it shows a certain solubility, soluble or slightly soluble. In water, its solubility is poor, which is due to the characteristics of the functional groups contained in the molecular structure. Structures such as tert-butoxycarbonyl and pyridine rings limit the polarity of the molecule, so it is difficult to dissolve in water with strong polarity.
Its density is also a physical property that cannot be ignored. Although the exact density value needs to be determined by precise instruments, generally speaking, the density is similar to that of common organic compounds. This density characteristic is of great significance for understanding its distribution in different media during related chemical reactions and separation and purification processes.
In addition, the stability of this substance is also worthy of attention. Under normal storage conditions, if you avoid light, high temperature and contact with strong oxidants, strong acids and bases, etc., it can maintain a relatively stable state. However, under specific conditions, such as high temperature or strong acid environment, the structure of tert-butoxycarbonyl may change, affecting its chemical properties and applications.

2-% (tert-butyloxycarbonyl) -aminopyridine-5-carboxaldehyde, the Chinese name is often 2 - (tert-butyloxycarbonyl amino) pyridine-5-formaldehyde, which is commonly used in organic synthesis reactions.
In the construction of nitrogen-containing heterocycles, the aldehyde group and amino group can be used as key reaction check points. For example, under certain conditions, the aldehyde group can be condensed with amine compounds to form imines, which can be converted into nitrogen-containing heterocyclic compounds with diverse structures through reduction and other steps.
It is also common in the field of pharmaceutical chemical modification. Because tert-butoxycarbonyl amino can be used as an amino protecting group, the protecting amino group is not affected in the reaction. After the specific steps are completed, the protecting group is selectively removed to achieve precise modification of the amino group on the pyridine ring, so as to introduce specific pharmacoactive groups and optimize the activity and pharmacogenicity of drug molecules.
In addition, in some multi-step synthesis of complex natural products or biologically active molecules, the compound can be used as an important intermediate. By rationally designing the reaction route, using its aldehyde and amino properties, the complex structure of the target molecule is gradually constructed, providing an effective way for the synthesis of organic compounds with unique structures and functions.

Today there is a question about the market price of 2- (tert-butoxycarbonyl) -aminopyridine-5-formaldehyde. This is a key material in the field of fine chemicals and is widely used in many fields such as drug synthesis. However, its market price often changes due to many factors.
The first to bear the brunt is the cost of raw materials. The price fluctuations of tert-butanol, pyridine and other raw materials have a huge impact on their costs. If the raw materials are abundant and cheap, the cost of 2- (tert-butoxycarbonyl) -aminopyridine-5-formaldehyde may decrease; conversely, if the raw materials are scarce and the price rises, the cost will increase and the price will fluctuate accordingly.
Furthermore, the simplicity and efficiency of the production process also affect its price. Advanced and efficient processes can reduce energy consumption and yield, thereby reducing costs, selling prices or being close to the people; if the process is backward, high energy consumption and low yield, the cost will be high, and the price will be high.
The relationship between supply and demand in the market is also the key. If the demand is strong and the supply is limited, the price will rise; if the market is saturated and the supply is excessive, the price will inevitably fall.
At present, it is difficult to understand the price without the exact market. To know the exact price, when you check the chemical product trading platform in detail, consult the supplier or industry experts, you can get the actual price. The chemical market is constantly changing, and real-time prices can only be found in current market information.

2-%28tert+-+butyloxycarbonyl%29-aminopyridine-5-carboxaldehyde is 2- (tert-butoxycarbonyl) -aminopyridine-5-formaldehyde, which has a wide range of uses in the field of organic synthesis.
It can be used as a key intermediate to construct complex nitrogen-containing heterocyclic compounds. Nitrogen-containing heterocyclic rings play an important role in many natural products, pharmaceutical molecules and materials science. From the perspective of medicinal chemistry, by performing specific chemical reactions on 2- (tert-butoxycarbonyl) -aminopyridine-5-formaldehyde, various functional groups can be introduced to construct drug molecules with specific biological activities. For example, by reacting with nucleophiles, new carbon-nitrogen bonds or carbon-carbon bonds can be formed, expanding the molecular skeleton and laying the foundation for the creation of new drugs.
In the field of materials science, using this material as a starting material, materials with unique photoelectric properties can be prepared through a series of reactions. For example, by connecting with other conjugated structural units, conjugated polymers with specific luminescent or electrical conductivity can be synthesized, which can be used in optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells.
In addition, in organic synthesis methodology research, 2 - (tert-butoxycarbonyl) -aminopyridine-5 -formaldehyde is often used as a model substrate to explore new reaction pathways and reaction mechanisms. Researchers can develop more efficient and green organic synthesis methods by studying the chemical reactions they participate in, and promote the development of organic chemistry.