2-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE

2-%28TERT+-+BUTOXYCARBONYLAMINO%29PYRIDINE, the Chinese name is often 2 - (tert-butoxycarbonyl amino) pyridine, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Gain tert-butoxycarbonyl (Boc) is a common protective group of amino groups. In the construction process of many complex organic molecules, it can protect the amino group from unnecessary participation in the reaction process, so as to ensure that the reaction proceeds according to the expected path. After the specific reaction step is completed, the tert-butoxycarbonyl is removed under suitable conditions to restore the activity of the amino group, and then participate in the subsequent reaction. This is particularly important in the synthesis of complex organic molecules such as peptides and alkaloids.
Furthermore, in the field of medicinal chemistry, 2 - (tert-butoxycarbonyl amino) pyridine also plays an important role. It is often used as the starting material or key structural fragment in the design and synthesis of many drug molecules. By modifying and transforming its pyridine ring and amino protecting group, a library of compounds with specific pharmacological activities can be constructed for screening lead compounds with potential medicinal value, laying the foundation for the development of new drugs.
At the same time, in the field of materials science, materials derived from 2 - (tert-butoxycarbonyl amino) pyridine show unique properties. For example, introducing it into polymer systems may endow materials with special optical, electrical or mechanical properties, thus providing new ideas and approaches for the development of new functional materials.

To prepare 2 - (tert-butoxycarbonyl amino) pyridine, there are three methods.
One is to use 2-aminopyridine as the starting material. This 2-aminopyridine and di-tert-butyl dicarbonate in suitable solvents, such as dichloromethane, N, N-dimethylformamide, and then supplemented with acid binding agents, such as triethylamine and pyridine, at moderate temperatures, usually between room temperature and 50 degrees Celsius. During this process, the tert-butoxycarbonyl of di-tert-butyl dicarbonate will combine with the amino group of 2-aminopyridine to obtain the target product. After the reaction is completed, the pure 2- (tert-butoxycarbonyl amino) pyridine can be obtained by extraction and column chromatography.
The second is started with 2-halopyridine. The reaction of 2-halopyridine and tert-butoxycarbonyl azide is heated in a suitable solvent with the assistance of catalysts and ligands such as palladium or copper. The catalyst can activate the carbon-halogen bond of 2-halopyridine, and the tert-butoxycarbonyl azide provides the tert-butoxycarbonyl amino, and the two react to form the target. After the reaction, the product can also be obtained by separation and purification by distillation and recrystallization.
The third is from pyridine derivatives. If the specific position of the pyridine derivative has a transformable group, such as ester group, cyano group, etc. First convert this group into an amino group, and then react with di-tert-butyl dicarbonate according to the first method to introduce tert-butoxycarbonyl to obtain 2- (tert-butoxycarbonyl amino) pyridine. This route requires multiple steps of reaction, and each step requires fine control of the reaction conditions to ensure the purity and yield of the product.
These three methods have their own advantages and disadvantages. In actual preparation, the choice needs to be made carefully according to factors such as raw material availability, cost, and product purity requirements.

2 - (tert-butoxycarbonylamino) pyridine is a key intermediate in the field of organic synthesis. Its physical properties are unique, so let me tell you one by one.
Looking at its properties, it is mostly white to light yellow crystalline powder under normal conditions. This form is easy to store and use, and it is convenient for many reaction operations.
When it comes to the melting point, it is about a specific temperature range. This temperature characteristic is of great significance in identification and purity determination. Accurate understanding of the melting point can help chemists clarify the purity geometry of the substance. If impurities are mixed, the melting point often changes.
Its solubility also has characteristics, and it shows good solubility in some organic solvents, such as common tetrahydrofuran and dichloromethane. This characteristic makes it able to fully contact and mix with other reactants in organic synthesis, which greatly promotes the smooth progress of the reaction. However, the solubility in water is not good, which needs to be taken into account in the design of the reaction system and subsequent product separation.
In addition, the stability of 2 - (tert-butoxycarbonyl amino) pyridine cannot be ignored. Under normal conditions, it has a certain stability and can be properly stored. However, in the case of extreme chemical environments such as strong acids and strong bases, the structure is easily damaged, and the chemical properties are changed accordingly. In conclusion, being familiar with the physical properties of 2 - (tert-butoxycarbonyl amino) pyridine plays an indispensable role in reaction design, condition optimization, product purification, and many other aspects for organic synthesis chemists, laying a solid foundation for the synthesis of more complex and functionally specific organic compounds.

2-% (TERT - BUTOXYCARBONYLAMINO) PYRIDINE, which is 2 - (tert-butoxycarbonyl amino) pyridine, is a crucial compound in the field of organic synthesis. It has the following chemical properties:
From the perspective of solubility, the compound exhibits good solubility in common organic solvents such as dichloromethane, chloroform, tetrahydrofuran, etc. This property brings great convenience to the organic synthesis operation because it can fully contact the reactants in the homogeneous system, thereby greatly promoting the smooth progress of the reaction.
In terms of stability, 2 - (tert-butoxycarbonyl amino) pyridine is quite stable under conventional conditions. However, it should be noted that the tert-butoxycarbonyl in its molecule will undergo a deprotection reaction under specific conditions in case of strong acid or high temperature environment. This reaction characteristic is extremely critical in organic synthesis. Synthesizers can use this characteristic to realize the protection and deprotection of amino groups at an appropriate stage, and then precisely control the reaction process and product structure.
In an alkaline environment, the nitrogen atom in the 2- (tert-butoxycarbonyl amino) pyridine molecule can exhibit a certain alkalinity due to its lone pair of electrons, which can react with acids to form corresponding salts. At the same time, the presence of pyridine rings endows the compound with certain aromaticity and conjugation effects, which stabilize the distribution of its electron cloud, which has a significant impact on its chemical activity and reaction selectivity. In the electrophilic substitution reaction, the substitution check point on the pyridine ring is affected by the electronic and spatial effects of the amino group and the tert-butoxycarbonyl group, which exhibits specific selectivity. Usually, the amino group is an ortho-para-localization group, while the tert-butoxycarbonyl group has a large steric resistance. The combined effect of the two makes the reaction more inclined to substitution at a specific position of the pyridine ring, providing the possibility for the synthesis of organic compounds with specific structures.
Furthermore, there are multiple active check points in the 2 - (tert-butoxycarbonyl amino) pyridine molecule that can participate in the reaction, which lays the foundation for its participation in various reactions as a key intermediate in organic synthesis. It can construct complex and diverse organic compounds by condensation, substitution, addition and other reactions with different reagents, and has broad application prospects in many fields such as medicinal chemistry and materials science.

I look at your question, but I am inquiring about the price of 2 - (tert-butoxycarbonyl amino) pyridine in the market. However, the price of this product often changes due to multiple reasons, and it is difficult to determine.
Its price may be affected by the following things. First, the production source is different, and the price is also different. If it is a well-known factory with excellent craftsmanship and high quality, the price may be high; if it is produced by ordinary manufacturers, the price may be slightly lower. Second, the quantity is related to the price. If the purchase volume is large, the merchant may give a discount; if the quantity is small, the price may not change. Third, the supply and demand of the market is also the main reason. If there are many people who want it, the supply is small, and the price will rise; on the contrary, if the supply exceeds the demand, the price may drop.
Looking at the past market conditions, the price of this substance may be between a few yuan and tens of yuan per gram. However, this is only a rough outline. The actual price should be based on the current market conditions. Consult suppliers, chemical raw material trading platforms, or know the range of their near-current prices. And for chemical products, transactions often involve qualifications, transportation, etc. This should also be noted before the total fee can be known.