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What are the chemical properties of 2-mercaptopyridine-3-carboxylic acids?
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2-Hydroxy-3-naphthoic acid, its chemical properties are as follows:
This substance is white to light yellow powder, slightly soluble in cold water, slightly more soluble in hot water, and also has some solubility in organic solvents such as ethanol, ether, and chloroform. From its chemical structure, the molecule contains both hydroxyl (-OH) and carboxyl (-COOH), which give it unique chemical properties.
In terms of acidity, due to the carboxyl group, 2-hydroxy-3-naphthoic acid is acidic and can react with bases to form corresponding carboxylate. For example, when reacting with sodium hydroxide (NaOH), the hydrogen atoms in the carboxyl group will be replaced by sodium ions to form 2-hydroxy-3-naphthoate and water. The presence of the hydroxy group makes the substance able to participate in many reactions. On the one hand, the hydroxyl group can undergo esterification reaction. Under the action of concentrated sulfuric acid and other catalysts, it reacts with alcohols to form ester compounds. On the other hand, the hydroxyl group may also be oxidized. In case of strong oxidants, the hydroxyl group may be oxidized to an aldehyde group or even a carboxyl group, which changes the molecular structure and properties.
In addition, the phenyl ring structure in 2-hydroxy-3-naphthoic acid makes it have certain aromaticity, and electrophilic substitution reactions can occur. The electron cloud density on the benzene ring is relatively high, and it is vulnerable to attack by electrophilic reagents. For example, under appropriate conditions, halogenation reactions can occur, and halogen atoms replace hydrogen atoms on the benzene ring; nitrification reactions can also occur, introducing nitro groups.
2-Hydroxy-3-naphthoic acid is widely used in the field of organic synthesis due to its unique chemical properties. It is often used as an important intermediate for the preparation of various dyes, drugs and other organic compounds.
What are the common application fields of 2-mercaptopyridine-3-carboxylic acid
2-Hydroxypyridine-3-carboxylic acid, commonly known as niacin, is an important organic compound. Its common application fields are many, as detailed below:
First, in the field of medicine, niacin has significant effect. It can regulate human blood lipids, increase the level of high-density lipoprotein cholesterol, reduce the content of low-density lipoprotein cholesterol and triglycerides, so as to effectively prevent and treat cardiovascular diseases. Moreover, as vitamin B3, it is indispensable to the human body and participates in many metabolic processes. Lack of niacin can easily lead to pellagra, dermatitis, diarrhea, dementia and other symptoms. Supplementation of niacin can prevent and treat such diseases.
Second, in the food industry, niacin plays an important role. As a food nutrient enhancer, it is often added to bread, flour, grains and other foods to increase the nutritional value of food and meet the human body's demand for vitamins. Especially for areas where corn is the staple food, because most of the niacin in corn is combined, it is difficult for the human body to absorb. Fortification of niacin can prevent niacin deficiency.
Third, in the feed industry, niacin is also indispensable. As an animal feed additive, it is of great significance to animal growth and development. It can promote animal metabolism, improve feed conversion rate, enhance animal immunity and disease resistance, and ensure the healthy growth of animals. For example, in the breeding of pigs, chickens and other livestock and poultry, appropriate addition of niacin can improve its production performance.
Fourth, in the chemical industry, niacin is a key organic synthesis raw material. It can be used to synthesize a variety of drugs, dyes, fragrances and other organic compounds. Niacinamide synthesized from niacin is widely used in cosmetics, medicine and food industries.
What is the preparation method of 2-mercaptopyridine-3-carboxylic acid?
To make di-hydroxypropyl-3-chloroacetic acid, the method is as follows:
First take an appropriate amount of propylene oxide and place it in a clean reactor. The environment in the kettle needs to be purified first to avoid impurities. Propylene oxide is the starting material for the reaction. Whether its quality is pure or not depends on the quality of the product.
Take chloroacetic acid for the second time, and slowly add it to the kettle after grinding. Chloroacetic acid is also a key raw material. Its particle size is fine, which is conducive to the sufficient reaction. When adding, control the rate and do not overreact.
Next, add an appropriate amount of catalyst. The choice of catalyst, when combined with the nature of this reaction, can promote the reaction speed, and increase the yield of the product. Add it, stir it evenly, so that the various products are fused seamlessly.
Then, adjust the temperature in the kettle to a suitable degree. When this degree is precisely controlled, if it is too high, the side reaction will occur, and if it is too low, the reaction will be slow. Generally speaking, it is appropriate to take a specific temperature range and fine-tune it according to specific circumstances.
During the reaction, continue to observe, observe its phenomenon, and measure its parameters. When the reaction reaches the expected stage, the reaction liquid is obtained.
After the reaction liquid is separated and purified. First, the method of distillation is used to remove the low-boiling matter. During distillation, the temperature and pressure are controlled to improve the separation effect. Following that, the method of extraction is used to extract the desired substance in a specific solvent. After drying, crystallization and other steps, pure di-hydroxypropyl-3-chloroacetic acid can be obtained.
This method of preparation requires all steps to be followed, and all conditions can be controlled to obtain good results and obtain high-quality products.
What is the price range of 2-mercaptopyridine-3-carboxylic acid in the market?
I am a merchant of the world. I sell 2-pentylpyridine-3-carboxylic acid in the market. Its price varies with time and place, and it also depends on the quality.
Generally speaking, if this drug is on the market, if the quality is average, its price per catty is between 100 gold and 300 gold. If the quality is high and pure, it may reach 500 gold, or even thousands of gold. Because of its wide range of uses, it is used in medicine and chemical industry, so the price fluctuates.
If there are many buyers and few suppliers, the price will rise; if there are many producers and few applicants, the price will be depressed. And the place it is made of is different, and the methods used are different, which can affect its quality, and then affect its price.
The common situation of the city, the price is not constant, sometimes high, sometimes low, merchants often observe changes in the market to seek their own profits. Buyers should also review their quality and price before they can get it.
How safe and toxic are 2-mercaptopyridine-3-carboxylic acids?
2-% pentylcinnamic acid-3-carboxylic acid is an organic compound. Its safety and toxicity are quite complex and need to be investigated in detail.
In terms of safety, this compound may have certain safety in specific application scenarios at appropriate doses. In some drug development or cosmetic ingredient considerations, it can only be regarded as safe to a certain extent if it is confirmed through rigorous experiments and evaluations that it does not cause significant negative effects on organisms in the established mode of use and dosage range, such as no obvious irritation and sensitization. However, this safety conclusion is highly dependent on rigorous experimental data and scientific evaluation.
Theory of its toxicity, when the dose exceeds a certain threshold, or has adverse effects on organisms. For example, it may have toxic effects on cells and interfere with normal physiological functions of cells, such as affecting cell metabolism, proliferation and other processes. In animal experiments, high doses of exposure may cause damage to organs, such as liver, kidneys and other important organs have abnormal functions or pathological changes. It may also interfere with the endocrine system, affect hormone balance, and then affect physiological processes such as growth, development and reproduction of organisms. In addition, if the compound has potential genetic toxicity, it may also cause damage to genetic material and cause serious consequences such as genetic mutations.
Overall, the safety and toxicity of 2-% pentylcinnamic acid-3-carboxylic acid requires professional experiments, including multi-level studies such as cell experiments, animal experiments, and even human clinical trials. Accurate judgments are based on detailed data, and must not be based solely on speculation. It must be treated with a scientific and rigorous attitude.