2-[(S)-1-Hydroxyethyl]pyridine

2-%5B%28S%29-1-Hydroxyethyl%5Dpyridine, Chinese name 2- [ (S) -1-hydroxyethyl] pyridine, this compound has a wide range of uses. In the field of medicinal chemistry, it is often used as a key intermediate. Because of its unique chiral structure, it can play an important role in asymmetric synthesis, helping to prepare drug molecules with specific chiral configurations. It plays an important role in the synthesis process of many chiral drugs, which can effectively improve the activity and selectivity of drugs.
In the field of materials science, it also has applications. With its molecular structure properties, it can participate in the preparation of some functional materials. For example, in the synthesis of some organic optoelectronic materials, 2- [ (S) -1-hydroxyethyl] pyridine can contribute its special electron cloud distribution and spatial structure, endowing the material with unique optical and electrical properties, thus meeting the requirements of material properties in different scenarios.
In the field of catalysis, this compound can sometimes act as a ligand to coordinate with metal ions to form a specific catalytic active center. The formed complex catalyst exhibits good catalytic performance in some organic reactions, can effectively catalyze the progress of various reactions, improve the reaction efficiency and product yield, and is of great significance to the development of organic synthesis chemistry.

To prepare 2 - [ (S) -1 -hydroxyethyl] pyridine, there are three methods.
First, the chiral source is used as the starting material. Select (S) -ethyl lactate, and first react with pyridine under the action of a strong base such as sodium hydride in an anhydrous organic solvent such as tetrahydrofuran at low temperature. The ethyl ester group of ethyl lactate undergoes nucleophilic substitution with pyridine to obtain an intermediate product. The product is then hydrolyzed under mild conditions, the pH value is adjusted, and the chiral purity is easy to control.
Second, asymmetric catalytic synthesis is used. Using pyridine and acetaldehyde as raw materials, chiral ligands and metal catalysts, such as chiral phosphine ligands and rhodium catalysts, are added to a suitable solvent such as toluene. Under a certain temperature and pressure, asymmetric addition reactions are catalyzed. After the reaction is completed, the product can be obtained by column chromatography and other means. This method has high atomic economy and mild conditions, but the catalyst cost is high and the requirements for reaction equipment are also high.
Third, biocatalysis. Select an enzyme with specific stereoselectivity, such as alcohol dehydrogenase. Pyridine and acetaldehyde are used as substrates in a buffer solution system at a suitable temperature and pH. After the reaction, the product is obtained by extraction, concentration and other operations. The method is environmentally friendly and has good selectivity, but the enzyme stability is limited, and there are challenges in expanding the reaction scale.

2-%5B%28S%29-1-Hydroxyethyl%5Dpyridine, organic compounds are also. They have specific physical properties, which are related to the state of matter, melting and boiling point, solubility and density, and are of great significance in chemical research and industrial applications.
In terms of their physical state, under normal temperature and pressure, they are mostly liquid and have a certain fluidity. Due to the moderate force between molecules, it is not enough to solidify into a solid state or cause gasification.
As for the melting point and boiling point, the melting point is about -20 ° C to -10 ° C, and the boiling point is in the range of 200 ° C to 210 ° C. The low melting point is due to the fact that the intermolecular force is not extremely strong, which is easy to overcome when heating up, and the lattice structure is destroyed and melted; the high boiling point is due to the existence of hydrogen bonds and van der Waals forces between molecules, which requires more energy to make the molecule break free from the liquid phase and transform into the gas phase.
In terms of solubility, it can be soluble in common organic solvents, such as ethanol, ether, etc. This is because the compound and the organic solvent molecules can form hydrogen bonds or have similar molecular polarities. According to the principle of "similar compatibility", it is soluble. However, the solubility in water is limited, because although hydroxyl groups can form hydrogen bonds with water, the hydrophobicity of pyridine rings limits its solubility in water. The density of
is about 1.05-1.10 g/cm ³, which is slightly heavier than water. Due to the type and arrangement of atoms in the molecular structure, the mass per unit volume is slightly larger than that of water.
In summary, the physical properties of 2-%5B%28S%29-1-Hydroxyethyl%5Dpyridine are restricted by the molecular structure, and these properties profoundly affect their behavior in chemical reactions, separation and purification, and practical applications.

2-%5B%28S%29-1-Hydroxyethyl%5Dpyridine is an organic compound, often used as an intermediary in the synthesis of pharmaceuticals, pesticides and functional materials. In the current market, this compound has a good prospect.
From the perspective of the field of medicine, with the in-depth study of disease mechanisms, the demand for specific structural organic compounds is increasing. 2-%5B%28S%29-1-Hydroxyethyl%5Dpyridine Due to its unique chemical structure, it can be used as a key intermediate to participate in the synthesis of many drugs. For example, in the development of some new anti-infective drugs and drugs for the treatment of neurological diseases, this compound may play an important role. Today, the pharmaceutical industry has an urgent need for innovative drugs, and R & D investment continues to increase, bringing broad market opportunities to 2-%5B%28S%29-1-Hydroxyethyl%5Dpyridine.
In the field of pesticides, there is an increasing demand for high-efficiency, low-toxicity and environmentally friendly pesticides. 2-%5B%28S%29-1-Hydroxyethyl%5Dpyridine may be used to synthesize pesticides with such characteristics. With the development of agricultural modernization, the concept of precision agriculture has been deeply rooted in the hearts of the people, and the demand for high-quality pesticides is also increasing day by day. The application prospect of this compound in pesticide synthesis may be brighter.
Functional materials, with the progress of science and technology, the demand for special performance functional materials continues to emerge. 2-%5B%28S%29-1-Hydroxyethyl%5Dpyridine can be chemically modified to construct functional materials with unique electrical, optical or other properties, which may have potential applications in electronic devices, optical materials and other fields. Coupled with the continuous innovation of materials science, the demand for new structural basic materials drives its market expansion.
However, its market also has challenges. The synthesis process may need to be optimized to improve yield, reduce costs and enhance market competitiveness. And the market competition or fierce, the need for relevant enterprises and research institutions to continue to innovate, improve product quality and performance, in order to take the lead in the market. In short, 2-%5B%28S%29-1-Hydroxyethyl%5Dpyridine market prospects are broad, but also need to deal with many challenges.

2-%5B%28S%29-1-Hydroxyethyl%5Dpyridine is an organic compound. During storage and transportation, it should be expressed in the ancient words of "Tiangong Kaiwu", and many matters should be paid attention to.
First words storage. This compound should be placed in a cool, dry and well-ventilated place. Because it may be sensitive to heat and humidity, if it is placed in a warm and humid place, it may deteriorate. It needs to be stored separately from oxidants, acids and other substances, because of contact with it, or chemical reactions may be caused, which will damage its quality. And the storage area should be clearly marked, so that the user can clearly know its characteristics and attention.
As for transportation, be sure to ensure that the packaging is complete and well sealed. Avoid package damage due to vibration or collision during transportation, causing compound leakage. The means of transport should be clean and dry, and there should be no residual substances that may react with it. Temperature and humidity should be strictly controlled during transportation to prevent extreme conditions from affecting its stability. At the same time, transport personnel should be familiar with the dangerous characteristics of this compound and emergency treatment methods. In the event of an accident, they can respond quickly and appropriately to ensure the safety of personnel and the environment from pollution.
In short, 2-%5B%28S%29-1-Hydroxyethyl%5Dpyridine in storage and transportation, it is necessary to take care of the environment, packaging, personnel and other aspects to ensure its quality and safety.