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What is the chemical structure of 4-amino-3,6-dichloro-2-pyridinecarboxylic acid (9CI)?
The chemical structure of 9-hydroxy-3,6-dioxo-2-heptanoenoic acid (9CI) is an important matter in chemical research. In this compound, the hydroxyl group (-OH) is a group with active chemistry, which can react with many substances, and is of great significance in the fields of organic synthesis and medicinal chemistry. It is connected to a specific location of the molecular structure, which has a profound impact on the physical and chemical properties of the molecule.
The part of 3,6-dioxygen participates in the formation of rings or specific structures with oxygen atoms, which greatly changes the electron cloud distribution and spatial conformation of the molecule. The high electronegativity of the oxygen atom makes the surrounding electron cloud biased towards itself, causing uneven local charge distribution, which affects the intermolecular forces and chemical reaction activities.
2-heptanoenoic acid part, containing carbon-carbon double bonds (C = C), endows the molecule with unsaturation. The carbon-carbon double bonds are electron-rich regions, which are easily attacked by electrophilic reagents and trigger a series of reactions such as addition. At the same time, the carbon chain length and structure of heptanoenoic acid also affect the solubility and stability of the molecule.
The overall structure of this compound, the interaction and interaction of each part determine its unique chemical properties and reactivity. In organic synthesis, derivatives with specific functions can be prepared according to their structural characteristics and through specific reaction paths. In the field of drug development, the relationship between its structure and biological activity may provide key clues for the creation of new drugs.
What are the physical properties of 4-amino-3,6-dichloro-2-pyridinecarboxylic acid (9CI)?
9-Hydroxy-3,6-dioxy-2-morpholineacetic acid (9CI), the physical properties are as follows:
Its appearance is often white to light yellow crystalline powder, which is fine and uniform in appearance. Under normal temperature and pressure, the properties are quite stable. When encountering topics, open flames or strong oxidants, it is prone to danger, just like a reclining tiger. In case of disturbance, it will break out and hurt people.
In terms of solubility, it is slightly soluble in water, just like snowflakes falling lightly on the surface of a lake and partially melting. In organic solvents, such as ethanol and acetone, the dissolution is better, just like fish getting water and blending into it. This property allows it to choose the appropriate solvent according to the needs in many chemical synthesis and formulation to achieve the purpose of expected dispersion and reaction.
The melting point range is roughly in a specific range, and this temperature is just like the node of its metamorphosis. At this temperature, it gradually melts from a solid state to a liquid state. The change of shape also implies the transformation of its internal molecular arrangement and energy state. Accurate determination of the melting point is of great significance when identifying its purity and quality.
Its chemical activity is highlighted under specific conditions, and the active groups such as hydroxyl groups, oxygen heterocycles, and carboxyl groups contained in the molecular structure are like hidden sharp edges, capable of reacting with many reagents, such as esterification, substitution, condensation, etc., which are the stage for its chemical properties. In the field of organic synthesis, it is often regarded as a key raw material or intermediate, just like building a building block and participating in the construction of complex organic molecules.
What are the common uses of 4-amino-3,6-dichloro-2-pyridinecarboxylic acid (9CI)?
9-Hydroxy-3,6-disulfonic acid-2-naphthoate sodium (9CI), this substance is often used in a wide range of applications. It is often used as a dye intermediate in the industrial field. Due to the special structure of hydroxyl, sulfonic acid and sodium naphthoate, it plays a key role in dye synthesis. It can construct complex dye molecular structures through specific chemical reactions, providing a variety of color sources for the textile, printing and dyeing industries.
In the field of pharmaceutical research, it also has its own influence. Due to its unique chemical properties, it may participate in the modification and synthesis of drug molecules to improve drug stability, solubility and other characteristics. For example, some drug development that requires specific groups to enhance drug efficacy or improve pharmacokinetic properties may be used as an important raw material or intermediate.
In scientific research experiments, it is often used as an analytical reagent. Its special structure can react with specific substances for the detection and identification of other compounds. By observing the reaction phenomenon and analyzing the structure of the product, researchers can gain a deeper understanding of the chemical properties and reaction mechanism of related substances.
In summary, 9-hydroxy-3,6-disulfonic acid-2-naphthalate sodium (9CI) plays an important role in industry, medicine, scientific research and other fields by virtue of its own structural characteristics, and is of great significance to the development of various fields.
What are the synthesis methods of 4-amino-3,6-dichloro-2-pyridinecarboxylic acid (9CI)?
To prepare the 4-amino-3,6-difluoro-2-methoxybenzoic acid of 9CI, the following numbers can be used.
First, the benzoic acid derivative containing the corresponding substituent is used as the starting material and is prepared by multi-step reaction. First, a suitable benzoic acid parent is taken, and the position of the substituent on it is similar to the target product, but the amino group, fluorine and methoxy group are not all present. Fluorine atoms can be introduced first, often by nucleophilic fluoridation reaction. Choose a suitable fluorination reagent, such as potassium fluoride, etc., under suitable solvent and reaction conditions, the fluorine atom replaces the halogen atom at a specific position on the parent body to obtain a fluorobenzoic acid derivative. Then through nitrification reaction, nitro groups are introduced, and then nitro groups are converted into amino groups by reduction means. Commonly used reduction methods, such as metal and acid systems, or catalytic hydrogenation, convert nitro groups to amino groups. As for the introduction of methoxy groups, hydroxy-containing benzoic acid derivatives can react with methylating reagents, such as dimethyl sulfate, under alkali catalysis to form methoxy groups.
Second, the construction of benzene rings can be initiated. Using suitable benzene derivatives as raw materials, first through a Fourier-gram reaction, etc., a specific substituent is introduced into the benzene ring to build a basic skeleton. After that, fluorine, amino and methoxy groups are introduced in sequence. For example, halogen atoms are introduced first through a halogenation reaction, and then fluorine atoms are introduced by a nucleophilic substitution reaction. The introduction of amino groups can be carried out by means of diazotization reactions. The methoxy group is connected at an appropriate stage by a method similar to the above methylation reaction.
Third, other compounds containing carboxyl groups can also be considered as the starting point, and a series of functional group conversion and cyclization reactions can be used to prepare the target product. For example, some chain compounds containing carboxyl groups and suitable substituents are used as the starting materials to construct the benzene ring through intramolecular cyclization reaction. At the same time, the substituents on the ring are modified, and amino groups, fluorine and methoxy groups are gradually introduced to achieve the synthesis of 4-amino-3,6-difluoro-2-methoxybenzoic acid.
What is the price range of 4-amino-3,6-dichloro-2-pyridinecarboxylic acid (9CI) in the market?
9-Hydroxy-3,6-dihydro-2-pyranecarboxylic acid (9CI), this product is in the market, and its price is difficult to determine. The change in the price is related to many factors, such as the amount of production, the rise and fall of the demand, the complexity and simplicity of the system, and the quality.
If the production is wide and sufficient, and the supply exceeds the demand, the price may decline; on the contrary, if the production is thin and the source is lacking, the demand is too high, and the price may rise. The preparation method is labor-intensive, time-consuming, the cost increases, and the price is also high; if the method is simple, the cost will decrease, and the price may be cheap. Those with high quality are often high; those with poor quality are often low.
There may be different prices for this product in the market. Roughly speaking, if it is ordinary, the gram price may be between tens and hundreds of dollars; if it is high quality and pure, it may reach thousands of gold. However, these are all approximate estimates, and the actual price must change according to the market conditions. If you want to know the exact price, you should consult the merchants in the market in detail and compare their quotations to get a near-real price.