2-Pyridinecarboxylicacid,3-methyl-,methylester(9CI)

The chemical structure of 2-pyridinecarboxylic acid, 3-methyl-, methyl ester (9CI), is an organic compound with a specific atomic connection and spatial arrangement. Its core is a pyridine ring, which consists of five carbon atoms and one nitrogen atom to form a six-membered aromatic ring. In the second position of the pyridine ring, there is a methyl formate group formed by methylation of a carboxyl group, that is, a -COOCH group. In this group, the carbon atom is attached to the oxygen atom by a double bond, and then to another oxygen atom by a single bond, which is then connected to the methyl group. In the third position of the pyridine ring, there is a methyl group, that is, a -CH group. As a whole, the structure of this compound is formed by connecting a specific group at a specific position with a pyridine ring as a structure. This structure endows the compound with unique physical and chemical properties, which may be used in organic synthesis, medicinal chemistry and other fields or have specific uses and reactivity.

3-Methyl-2-methylpyridinecarboxylate (9CI), which is widely used. In the field of medicine, it can be used as a key intermediate to help synthesize many drugs with specific biological activities. For example, it may participate in the preparation of therapeutic drugs for specific diseases. With its unique chemical structure, it imparts specific curative effects and pharmacological properties to drugs, and plays a key role in the treatment of diseases.
In the chemical industry, it also plays an important role. In the synthesis of fine chemicals, it can be used as a starting material or reaction intermediate to participate in the synthesis of a variety of high-value-added fine chemicals. Like some special functional coatings, fragrances, etc., with its chemical properties, it can improve product performance, enhance product quality and market competitiveness.
In addition, in organic synthesis research, it is often used as a model compound. By conducting various reaction studies on it, researchers explore new synthesis methods and reaction paths, promote the development of organic synthesis chemistry, provide ideas and methods for the synthesis of more complex organic compounds, and then promote technological innovation and progress in related fields.

Methyl 3-methyl-2-pyridinecarboxylate (9CI) is one of the organic compounds. Its physical properties are particularly important and are related to many characteristics and applications of this compound.
Looking at its properties, under normal temperature and pressure, it is mostly in the form of a colorless to light yellow liquid, with a clear texture, which is convenient for many operations and observations. Its odor often has a weak special smell. Although it is not strong and pungent, it can be recognized by careful sniffing. This odor characteristic may help to identify the compound in a specific environment.
Boiling point is a key parameter for measuring its volatility. The boiling point of this compound is within a certain range, and the specific value varies slightly according to the experimental conditions, about [X] ° C. This boiling point indicates that at the corresponding temperature, the liquid and gaseous states reach equilibrium, which can be accurately controlled in separation operations such as distillation.
Melting point is also an important physical property. Its melting point value is about [X] ° C. At this temperature, the substance changes from solid to liquid state. This characteristic plays a significant role in crystallization, purification and other processes.
In terms of density, its value is about [X] g/cm ³, which reflects the mass of the substance per unit volume. This parameter is crucial in the process of solution preparation, density-related calculation, and material balance calculation, which helps to accurately control the amount of substance.
In terms of solubility, methyl 3-methyl-2-pyridinecarboxylate has good solubility in common organic solvents such as ethanol and ether, and can be well miscible with these solvents; however, the solubility in water is very small. This difference in solubility provides a basis for its separation, purification and reaction medium selection. It can be extracted with organic solvents to achieve separation from water-soluble impurities.
The refractive index is also the physical property of the compound, and its refractive index is about [X]. This parameter is closely related to the molecular structure of the substance. It can be used as an auxiliary means to identify the purity and structure of the compound, and is of great significance in optical related applications and analysis.

To prepare 2-pyridinecarboxylic acid, 3-methyl-, methyl ester (9CI), there are several common methods as follows.
One is to use 3-methylpyridine as the starting material. First, 3-methylpyridine is oxidized by an appropriate oxidant, such as potassium permanganate and other strong oxidants. Under a suitable temperature, pH and solvent environment, the methyl groups on the pyridine ring can be oxidized to carboxyl groups to obtain 3-methylpyridinecarboxylic acid. Subsequently, the product is mixed with methanol, an appropriate amount of concentrated sulfuric acid is added as a catalyst, and the esterification reaction is carried out by heating. Concentrated sulfuric acid can promote the reaction to proceed in the direction of generating esters. After a period of reaction, excess methanol is evaporated, and then the target products can be obtained through separation and purification. 2-pyridinecarboxylic acid, 3-methyl-, methyl ester.
Second, you can start from the pyridine derivative containing the corresponding substituent. If there are suitable pyridine derivatives with carboxyl protecting groups and methyl groups, first remove the carboxyl protecting groups to free the carboxyl groups. Then it reacts with methanol in the presence of a shrinking agent such as dicyclohexyl carbodiimide (DCC) and a catalyst 4-dimethylaminopyridine (DMAP). DCC can activate carboxyl groups, and DMAP can accelerate the reaction process. Through this condensation reaction, ester bonds are formed, and then the target compounds are obtained. After the reaction is completed, the urea by-products produced by the condensation reaction are removed by filtration, and then the product is purified by means such as column chromatography.
Third, the use of metal-organic chemical methods can also be considered. A suitable halogenated pyridine derivative, such as 3-methyl-2-halogenated pyridine, is reacted with a metal reagent such as an organolithium reagent or a Grignard reagent to introduce a carboxyl precursor. For example, by reacting with carbon dioxide, a carboxyl group can be introduced at the 2-position of the pyridine ring. Subsequent esterification with methanol under acidic conditions can produce the target product. This process requires attention to the strict requirements of metal reagents for reaction conditions, the reaction system needs to be anhydrous and oxygen-free, and the metal reagents have high activity. During operation, caution is required, and the reaction temperature and time are strictly controlled to ensure the smooth progress of the reaction and the yield and purity of the product.

Nowadays, the prospect of 2 - Pyridinecarboxylic acid, 3 - methyl -, methylester (9CI) in the chemical market is really an interesting topic.
From the perspective of industrial applications, its prospects are quite promising. This compound is often used as a key intermediate in the field of organic synthesis. Due to its unique structure, it can be derived from a variety of high-value organic compounds through various chemical reactions. In the pharmaceutical research and development branch, it may contribute to the creation of new drugs. Today's pharmaceutical industry has an increasing demand for novel chemical structures. Due to its unique chemical properties, this compound may become a jade in the eyes of medicinal chemists and be carved into a good medicine for the world.
Furthermore, in the field of materials science, it may also emerge. With the advancement of science and technology, the desire for high-performance materials continues to rise. 2 - Pyridinecarboxylic acid, 3 - methyl -, methylester (9CI) may find a place in the synthesis of new polymer materials due to its special physical and chemical properties.
However, it is also necessary to face up to the challenges it faces. The market competition is quite fierce, and new products in the chemical field are emerging one after another. To gain a firm foothold in the market, it is necessary to continuously optimize the production process, improve product quality, and reduce costs and increase competitiveness. And the chemical industry has stricter environmental protection requirements. The process of producing this compound must comply with environmental protection regulations, which is also one of the major tests on the way forward.
Overall, 2 - Pyridinecarboxylic acid, 3 - methyl -, methylester (9CI) has a bright future in the chemical market, but it also needs to deal with problems such as competition and environmental protection. If properly handled, it will be able to occupy a place in the market and contribute to the chemical industry.