2-Pyridinecarboxylicacid,3-fluoro-(9CI)

Water is the fuel oil of ancient times, or oil in modern times. Its nature is unique to ordinary things.
Looking at its shape, the water first emerged, black and thick in color, like a paste, flowing and sticky, unlike the smooth flow of clear water. Smell it, the gas is fresh and strong, pungent and unpleasant, very different from all kinds of fragrant things.
As for its flammability, it is particularly strange. When it burns, the fire is raging, and the flame is bright, far better than that of firewood. And it burns for a long time, which can be used for long-term lighting and heating. When a fire is near, it is very easy to ignite, and there is no need for complicated methods of igniting fire. If a fire starts, it will be difficult to extinguish, and if it burns in the wind, it will become more and more intense, just like a beast gaining the wind, which is unstoppable.
Furthermore, water is insoluble in water. Although it coexists in the same vessel, it is still distinct. Water is water by itself, and water by itself is water by itself. Stir it with things, temporarily mix and spin, and then divide it. If it is placed in the vessel, there may be light smoke curling on it for a long time, which seems to contain a faint breath.
There are also, the quality of water is slippery and greasy, and when touched, it will be dyed in the hands, which is difficult to clean quickly. Its properties can also erode. If it is stored in an ordinary
The nature of water is like this. When the ancients first encountered it, they were astonished and gradually realized that it was available. Therefore, they occasionally used it in lighting, cooking, etc. However, because of its strong nature, they must be used with caution to prevent the risk of accidents.

In "Tiangong Kaiwu", the main uses of mirabilite produced in Jiangyou (Jiangxi) are as follows.
First, it is used to make alkali. Mirabilite can react with certain substances to make alkali products. Alkali is widely used in many industries. In the printing and dyeing industry, it can assist dyes to better adhere to fabrics, improve dyeing effect, and make colors brighter and longer lasting. In the papermaking industry, it can help remove impurities in raw materials such as bamboo and straw, make paper purer and improve paper quality.
Second, it is used in medicine. In the field of traditional Chinese medicine, mirabilite has the effects of laxative, moisturizing dryness, clearing fire and reducing swelling. It has a significant effect on symptoms such as real heat stagnation, abdominal fullness and pain, and dry stool knots. Doctors will precisely control the dosage of mirabilite according to the specific symptoms and constitution of the patient, so as to achieve the best treatment purpose.
Third, it is used in glass manufacturing. In the process of glass firing, mirabilite plays a key role as a clarifying agent. It can reduce the viscosity of the glass liquid and promote the smooth discharge of bubbles in the glass liquid, thus making the glass texture more uniform and transparent, and greatly improving the quality of the glass. Whether it is daily window glass or exquisite glass products, mirabilite has contributed to it.
Fourth, it is used for leather tanning. Mirabilite participates in the leather tanning process, which can make the leather softer and tougher, and improve the quality and durability of the leather. After being treated with mirabilite, leather is not only more comfortable to wear, but also better able to maintain good performance in different environments. It is widely used in shoemaking, leather goods and other industries.

To prepare 3-alkyne-2-pentenoic acid (9CI), there are many ways to synthesize it. The following is the way to do it.
First, the corresponding halogenated olefin can be reacted with the alkyne fund reagent. Take a suitable halogenated olefin and make it meet with the alkynyl lithium or alkynyl magnesium reagent. This reaction must be carried out in a harsh environment with low temperature and no water and no oxygen to ensure the smooth reaction. The halogen atom on the halogenated alkenes is active, and it is easy to undergo nucleophilic substitution with the alkynyl base reagent. Then the intermediate containing alkynyl group and alkenyl group can be obtained. After appropriate oxidation steps, one end of it can be converted into carboxyl group, and the final target product is 3-alkynyl-2-pentenoic acid.
Second, propionate and suitable alkenyl halides are used as raw materials. The alkynyl group of propionate is nucleophilic, and the halogen atom of alkenyl halide can be attacked by nucleophilic reagents. Under the catalysis of base, the two meet and react to form an ester compound containing alkynyl group and alkenyl group. Then, by hydrolysis, the ester group is converted into a carboxyl group, and 3-alkyne-2-pentenoic acid can also be obtained. In this process, the choice of base is very critical, and the appropriate base needs to be carefully selected according to the specific situation of the reaction to achieve the best reaction effect.
Third, olefin metathesis reaction can be used. Select a suitable alkynyl-containing olefin and another alkenyl-containing compound, and with the help of an olefin metathesis catalyst, the two interact and rearrange to form a new carbon-carbon double bond. This reaction condition is relatively mild, but it requires a high catalyst, and a catalyst with good activity and selectivity needs to be selected. After forming the desired carbon frame, carboxylation step, carboxyl group is added to complete the synthesis of 3-alkyne-2-pentenoic acid.

What is the price of a certain acid (9CI) in the city today?
I heard that the price in the city often changes due to the quality, the wide and narrow source, and the amount of demand. This acid (9CI), if the quality is pure and excellent, the source is wide and the supply is sufficient, and the demand is not abundant, the price is flat; if the quality is rare but fine, the source is sparse and the supply is small, and the demand is numerous, the price must be high.
I heard that this kind of acid is in the city, and the price varies from time to time. In the past year, or worth a few catties of silver, there are also those who change with the times, and the price drops or rises. Usually, the price is between tens and hundreds of dollars per catty. If the weather is not good, there are few products, and those who use them are in a hurry, the price can be high, or even a thousand dollars a catty is unknown; if the product is high and those who use it are low, the price may be as low as a few dollars a catty.
However, there is no constant price in the market, and it is all about supply and demand. To know the exact price of this acid (9CI), you can only get it when you go to the market in person and ask the merchants, depending on the quality and time. And in the four-sided city, the price may also be different. There are differences in the north and the south, and the distance and proximity are different. It cannot be generalized.

9CI
Third, the oxidizer, and other substances should be stored separately. Tartaric acid is acidic, and when it meets, it will neutralize and reverse, and it will damage the tartaric acid itself. And oxidation or oxidation of tartaric acid can lead to oxidation and reaction, breaking its integrity. Therefore, when it is combined, it must be well divided and stored.
Fourth, it is appropriate to have suitable materials to contain leaks. In order to prevent the accidental leakage of tartaric acid, it can be quickly and effectively treated to avoid harm to the surrounding environment and people. For example, sand, lime, etc., can absorb leaked tartaric acid and then make proper disposal.