2-pyridinecarboxylic acid, 5-hydroxy-, methyl ester

Methyl 5-hydroxy-2-pyridinecarboxylate has a wide range of uses. In the field of medicine, it is often a key intermediate for the synthesis of a variety of specific drugs. Due to the structural characteristics of pyridine and hydroxyl groups, it is endowed with unique biological activity, which is conducive to the precise binding of drugs to specific targets. For example, in the preparation of some antimalarial drugs, methyl 5-hydroxy-2-pyridinecarboxylate can be converted into ingredients that can effectively inhibit the growth and reproduction of malaria parasites, providing strong support for malaria treatment.
In the field of materials science, it can participate in the synthesis of functional materials. With its chemical structure, it can polymerize with other monomers to construct polymer materials with special properties. For example, the preparation of sensing materials with high sensitivity to specific gases can quickly and accurately detect specific harmful gases in the field of environmental monitoring, and escort environmental safety.
In organic synthetic chemistry, it is an important building block for organic synthesis. Because its molecular structure contains active functional groups, it is easy to carry out various chemical reactions, such as esterification and amidation. Chemists can use this to build complex organic molecular structures, expand the variety and properties of organic compounds, and promote the continuous development of organic synthetic chemistry, providing more new compound options for many fields.

2-Pyridinecarboxylic acid, 5-hydroxy-, methyl ester, is one of the organic compounds. Its physical properties can be described in many ways.
Looking at its properties, under room temperature, or a crystalline solid, like a fine powder or tiny grains, the texture is relatively dense, and it shows a certain luster. The pure color is nearly white.
When it comes to the melting point, it is generally within a certain temperature range determined by many experiments. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. This specific temperature range is critical for the identification and purification of the compound.
Boiling point is also one of its important physical properties. Under specific pressure conditions, this substance will boil into a gaseous state, and its boiling point value reflects the strength of intermolecular forces, which is of great significance for the separation and purification of this compound in industrial production.
In terms of solubility, it varies from solvent to solvent. In polar solvents, such as water, the solubility is relatively limited, because the polarity of the molecular structure does not highly match that of water. However, in some organic solvents, such as ethanol and acetone, the solubility is relatively considerable. Due to the principle of similar compatibility, the molecular structure of organic solvents is more compatible with 2-pyridinecarboxylic acid, 5-hydroxy-, and methyl ester, so it can be better mixed and dissolved with each other.
In addition, its density is also a characteristic. The density of the compound is also the mass per unit volume. The density of the compound determines its position in the solution system and has a significant impact on chemical operations, such as extraction and delamination.
The physical properties of this compound have their own uses. They are indispensable factors in chemical research and industrial production, helping researchers and producers understand their characteristics and make good use of them.

To prepare 2-pyridinecarboxylic acid, 5-hydroxy-, methyl ester, you can follow the following method.
First take a suitable pyridine derivative as the starting material. This derivative needs to have a group that can be converted into a carboxyl group at the 2nd position of the pyridine ring and a group that can be modified into a hydroxyl group at the 5th position. Common compounds such as 5-halogenated pyridine-2-carboxylic acid esters, in which the halogen atom can be chlorine, bromine, etc. The halogen atom can be later converted into a hydroxyl group.
Place this starting material in a suitable reaction system, use a base as a catalyst, such as potassium carbonate, sodium carbonate, etc., in an organic solvent, such as N, N-dimethylformamide (DMF), dichloromethane, etc., and heat it to a suitable temperature to make the halogen atom undergo nucleophilic substitution reaction. Using a nucleophilic reagent containing hydroxyl groups, such as a mixed system of sodium hydroxide aqueous solution and alcohol, the halogen atom is replaced by a hydroxyl group to obtain 5-hydroxy-pyridine-2-carboxylic acid ester. This step requires fine control of temperature and reaction time. If the temperature is too high or the time is too long, side reactions may occur, such as ester hydrolysis. < Br >
After obtaining 5-hydroxy-pyridine-2-carboxylic acid ester, if it needs to be purified, recrystallization or column chromatography can be used. During recrystallization, select a suitable solvent, such as ethanol-water mixed solvent, and use the difference in solubility between the product and the impurity in the solvent at different temperatures to achieve separation and purification; column chromatography selects a silica gel column according to the polarity of the product and the impurity, and uses a suitable eluent, such as a mixture of petroleum ether and ethyl acetate, for elution and separation.
The purified product is the target compound 2-pyridine carboxylic acid, 5-hydroxy -, methyl ester. The whole synthesis process requires attention to the precise control of the reaction conditions, the inspection and purification of the products after each step of the reaction, so as to obtain high-purity target products.

I haven't heard the exact price of "2 - pyridinecarboxylic acid, 5 - hydroxy -, methyl ester" in the market. This is a fine chemical, and its price often varies depending on purity, quantity, vendor, and market supply and demand.
If you want the price, you can go to the chemical raw material trading platform, such as Gade Chemical Network, Mobell Chemical, etc., whose prices are listed in the public, which can be seen from different sources. Or directly inquire with chemical trading enterprises and reagent suppliers, such as Sinopharm Group Chemical Reagent Co., Ltd., search banner reagent, etc., by phone or email, to ask the price under specific specifications.
Furthermore, the difficulty of synthesizing this chemical also affects its price. If the synthesis is complicated, rare raw materials or special conditions are used, the price will be high; if the synthesis is simple and the raw materials are easily available, the price may be close to the people. In addition, the fluctuation of market demand also makes the price fluctuate. If there are many needs and few suppliers, the price will rise; otherwise, the price may fall. Therefore, if you want to know the exact market price, you should inquire from many parties and get it later.

2-Pyridinecarboxylic acid, 5-hydroxy-, methyl ester, this substance is used in many fields such as medicine, materials, agriculture, etc.
In the field of medicine, because of its unique chemical structure, or with potential biological activity. Or can be used as a drug intermediate to help synthesize drugs with specific curative effects. For example, for some disease targets, it is chemically modified and synthesized into lead compounds with therapeutic effects, laying the foundation for the development of new drugs.
In the field of materials, it can participate in the preparation of functional materials. With its structural properties, it gives materials specific properties. For example, in the synthesis of polymer materials, the introduction of this structural unit can improve the solubility and stability of the material, and even endow it with special optical and electrical properties, which can be applied in optical materials and electronic materials.
In the field of agriculture, or with biological activities such as antibacterial and antiviral, it can be developed as a new type of pesticide. It can effectively control crop diseases and pests, ensure crop yield and quality, and is more environmentally friendly than traditional pesticides, reducing the negative impact on the ecological environment.
In addition, in the field of organic synthesis, as a key intermediate, it participates in the construction of various complex organic compounds. With its specific functional group reactivity, it realizes a variety of organic reactions, expands organic synthesis paths and methods, and provides important raw materials and means for organic chemistry research and chemical production.