As a leading 2-PYRIDINECARBOXYLIC ACID, 5-BROMO- supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
2 - PYRIDINECARBOXYLIC ACID, 5 - BROMO - What is the main use of
5-Bromo-2-pyridinecarboxylic acid is an organic compound. It has a wide range of uses and can demonstrate its unique value in many fields.
In the field of medicinal chemistry, its role is crucial. It can be used as a key pharmaceutical intermediate to help synthesize many drugs with special curative effects. For example, when developing innovative drugs for the treatment of specific diseases, 5-bromo-2-pyridinecarboxylic acid can be used as a starting material to construct complex molecular structures with specific pharmacological activities through a series of fine chemical reactions. With its unique chemical structure, it can give unique properties to drug molecules, enhance the affinity between drugs and targets, and then improve drug efficacy. < Br >
In the field of materials science, it also has outstanding performance. It can participate in the preparation of functional materials with excellent performance. For example, by ingeniously combining and reacting with other compounds, materials with special optical and electrical properties can be prepared. These materials have potential applications in the field of optoelectronics, such as in new display technologies, optoelectronic devices, etc., providing a material basis for technological innovation in related fields.
In the field of organic synthetic chemistry, it is an extremely important synthetic building block. With the bromine atom in its structure and the carboxyl group on the pyridine ring, it can participate in a variety of organic reactions. For example, through halogenation reaction, esterification reaction, amidation reaction, etc., it precisely connects with other organic molecules to construct complex and diverse organic compounds, which greatly enriches the types of organic compounds and promotes the development of organic synthesis chemistry.
5-Bromo-2-pyridinecarboxylic acid plays an indispensable role in many important fields such as medicine, materials, and organic synthesis. With the continuous progress of science and technology, its application prospects will become increasingly broad.
2 - PYRIDINECARBOXYLIC ACID, 5 - BROMO - What are the physical properties of
5-Bromo-2-pyridinecarboxylic acid is an organic compound. Its physical properties are unique, let me tell you one by one.
Looking at its properties, under room temperature and pressure, it is mostly white to light yellow crystalline powder. This form is easy to store and use, and is also conducive to dispersion and participation in many chemical reactions.
When it comes to melting point, it is about 185-189 ° C. Melting point is one of the important physical characteristics of a substance. This specific melting point range can help identify the purity of the compound. If the purity is quite high, the melting point should be within this range; if impurities are mixed, the melting point may drop, and the melting range becomes wider.
As for solubility, 5-bromo-2-pyridinecarboxylic acid is slightly soluble in water. Water is a common solvent, and the slightly soluble properties of this compound indicate that the interaction between its molecules and water molecules is limited. However, it has slightly better solubility in organic solvents, such as ethanol and dichloromethane. This is because the molecular structure of organic solvents is similar to that of 5-bromo-2-pyridinecarboxylic acid, and according to the principle of "similarity and miscibility", the two are more easily miscible. This solubility characteristic is of great significance in the separation, purification and selection of reaction media for compounds.
In addition, the compound has a certain stability, and when it encounters strong oxidizing agents, strong acids, strong bases, etc., it can still undergo chemical reactions, resulting in structural and property changes. When storing, pay attention to environmental conditions to avoid contact with such substances and prevent deterioration.
The physical properties of 5-bromo-2-picolinecarboxylic acid play a significant role in organic synthesis, pharmaceutical chemistry and other fields, laying the foundation for related research and applications.
2 - PYRIDINECARBOXYLIC ACID, 5 - BROMO - What are the chemical properties of
5-Bromo-2-pyridinecarboxylic acid, which is white to light yellow crystalline powder, is quite stable in conventional environments. It has a certain acidity, which is due to the release of protons by the carboxyl group. In organic solvents, such as common ethanol and acetone, it has a certain solubility, but its solubility in water is relatively limited.
When it comes to chemical activity, carboxyl groups and bromine atoms give it a variety of reaction characteristics. Carboxyl groups can participate in many reactions, such as esterification with alcohols catalyzed by acids to generate corresponding ester compounds. This reaction is like a delicate technique that requires suitable conditions to promote. At the same time, it can also neutralize with bases to form carboxylic salts, which is like a balanced blend of the two forces.
As a check point for active substitution, bromine atoms can participate in nucleophilic substitution reactions. When encountering suitable nucleophilic reagents, bromine atoms can be replaced to derive compounds with more complex structures. This is like introducing new elements on a given track, allowing the chemical structure to move towards a new chapter. For example, by reacting with nitrogen-containing nucleophilic reagents, nitrogen-containing heterocyclic derivatives are expected to be constructed, opening up new paths for organic synthesis.
In the field of organic synthesis, 5-bromo-2-pyridinecarboxylic acid is like a shining star and is often used as a key intermediate. With its unique structure and reactivity, chemists can carefully construct various complex organic molecular structures, contributing to the research and development of medicinal chemistry, materials science, and many other fields, and helping to explore more compounds with unique properties and application value.
2 - PYRIDINECARBOXYLIC ACID, 5 - BROMO - What are the synthetic methods
The method of preparing 5-bromo-2-pyridinecarboxylic acid has been known for a long time, and it is described in detail below.
The first is to use 5-bromo-2-methylpyridine as the starting material. This compound and a suitable oxidizing agent, such as potassium permanganate or potassium dichromate, are placed in water or an organic solvent and heated to azeotrope. In the meantime, the methyl group is gradually oxidized to the carboxyl group to obtain 5-bromo-2-pyridinecarboxylic acid. Although this approach is straightforward, the amount of oxidant, reaction temperature and time all need to be carefully regulated, otherwise the product is impure and the yield is low. < Br >
The first time can be started with 5-bromo-2-cyanopyridine. The cyanyl group can be hydrolyzed into a carboxyl group. This hydrolysis reaction can be carried out under the catalysis of acid or base. When catalyzed by acid, sulfuric acid or hydrochloric acid are commonly used; when catalyzed by base, sodium hydroxide or potassium hydroxide are preferred. At a suitable temperature and time, the cyanyl group is gradually converted to obtain the desired 5-bromo-2-pyridinecarboxylic acid. However, the degree of hydrolysis, the separation and purification of the product are all key.
Another person uses pyridine-2-carboxylic acid as the starting material. First, the bromination reaction is carried out with an appropriate brominating reagent, such as bromine or N-bromosuccinimide (NBS). During the reaction, suitable solvents and catalysts need to be selected to ensure that the bromine atom is accurately substituted at the fifth position of the pyridine ring. However, in this process, the prevention and control of side reactions and the purification of the product are all aspects that cannot be ignored.
The above synthesis methods have advantages and disadvantages. In practical application, the choice should be weighed according to the availability of raw materials, cost considerations, and purity requirements of the product before the purpose of synthesis can be achieved.
2 - PYRIDINECARBOXYLIC ACID, 5 - BROMO - What is the price range in the market?
I look at the price range of "2 - + - pyridinecarboxylic acid, 5-bromo-" in the market. However, the price of this chemical product often changes due to multiple reasons, and it is difficult to be sure.
First, the production place is different, and the price varies. If it comes from a place where the grinding process and the raw materials are easy to obtain, the cost may be low, and the price may be slightly lower; if the place of origin is remote, the raw materials are difficult to obtain, and the price may be high.
Second, the purity is very important. For high purity, the price must be higher than for low purity because the preparation requires exquisite technology and strict procedures. For example, high-purity "2 - + - pyridine carboxylic acid, 5-bromo-" used for high-end scientific research must be more expensive than those for industrial general use.
Third, the supply and demand of the market also affects its price. If there are many people seeking at a time, but there are few producers, the price will rise; on the contrary, if the supply exceeds the demand, the price will fall.
Generally speaking, the price of crude and ordinary purity may be in the tens of yuan per gram. If it is high purity and used in special fields, the price per gram may reach hundreds of yuan, or even higher. However, this is only a rough estimate. The actual price needs to be consulted with the supplier of chemical raw materials, which depends on the real-time market.
