2 Pyridinecarboxylic Acid 3 Chloro 6 Trifluoromethyl
pyridine pyrrole pyrazine piperidine piperazine

2-pyridinecarboxylic acid, 3-chloro-6-(trifluoromethyl)-

    Specifications

    HS Code

    769301

    Name 3-chloro-6-(trifluoromethyl)picolinic acid
    Molecular Formula C7H3ClF3NO2
    Molecular Weight 225.55
    Appearance Solid (likely white to off - white)
    Melting Point Data may vary, needs experimental determination
    Boiling Point Data may vary, needs experimental determination
    Solubility In Water Low solubility, being an organic acid with fluorinated and chlorinated groups
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Acidity Weakly acidic due to the carboxylic acid group
    Pka Data may vary, needs experimental determination
    Chemical Stability Stable under normal conditions, but may react with strong bases and reducing agents

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    Frequently Asked Questions

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    What is the main use of 2-pyridinecarboxylic acid, 3-chloro-6- (trifluoromethyl) -?
    2 + - to its carboxyl group, 3 + -alkane-6- (triethylmethyl) - This substance is widely used.
    In the field of medicine, it is often a key raw material for the creation of various specific drugs. Due to its unique chemical properties, it can participate in delicate chemical reactions and build a special molecular structure, which is of great significance for the precise combination of drugs and biological targets. For example, in the development of some anti-cancer drugs, its participation can optimize drug activity and targeting, improve therapeutic effectiveness, and reduce damage to normal cells.
    In the field of materials, it also plays an important role. It can be used as a modifier to incorporate specific materials to improve material properties. For example, in polymer materials, the addition of this substance can enhance the mechanical properties of the material, such as improving its strength and toughness, making the material more durable and stable in different environments. After some high-performance engineering plastics are modified, they are widely used in industries with strict material requirements such as aerospace and automobile manufacturing.
    In the field of fine chemicals, it is an important intermediate for the synthesis of many fine chemicals. Through a series of chemical reactions, a variety of high value-added products can be derived, such as special fragrances, high-performance coatings, etc. Special fragrances are synthesized through their participation, and the aroma is unique and lasting; high-performance coatings have excellent corrosion resistance and wear resistance due to their existence, and are widely used in construction, shipping and other fields.
    It can be seen from the above that 2 + - to its carboxyl group, 3 + -alkane-6- (triethylmethyl) - plays an indispensable role in many fields such as medicine, materials, and fine chemicals, and is of great significance to promoting the development of related industries.
    What are the physical properties of 2-pyridinecarboxylic acid, 3-chloro-6- (trifluoromethyl) -
    2 + - to its carboxyl group, 3 + -alkane-6- (triethylmethyl) - The physical properties of this substance are as follows:
    Its properties are either solid or liquid, depending on the specific conditions. If it is solid, or has a certain crystalline form, the texture may be hard or soft, depending on the strength of the intermolecular force. If the intermolecular force is strong, the texture is hard and the structure is relatively regular; if the force is weak, the texture is soft, and the crystalline form is irregular.
    When it comes to melting point, the melting point may be in a specific range due to the specific group in the molecular structure, or the complex interaction between molecules. The presence of carboxyl groups, or the enhancement of intermolecular hydrogen bonds, increases the melting point. The alkyl part, because of its certain hydrophobicity, also affects the overall melting point. If the alkyl chain length increases, the intermolecular dispersion force increases, and the melting point may also rise.
    In terms of solubility, due to the carboxyl group, this substance may have a certain hydrophilicity, and may have a certain solubility in polar solvents such as water and alcohol solvents. However, the molecule also contains hydrophobic groups such as alkyl and triethylmethyl, so it may have a certain solubility in non-polar solvents such as alkane solvents. The overall solubility needs to weigh the relative influence of hydrophilic and hydrophobic groups.
    Density is also an important physical property. Its molecular structure determines the mass distribution per unit volume. The relative ratio of carboxyl and alkyl groups, spatial arrangement and other factors all affect the density. In general, compared with common organic compounds, if there are many heavy atoms in the molecule, or the intermolecular accumulation is close, the density is relatively large.
    In addition, the refractive index of this substance is also affected by its molecular structure. Different groups have different refractive abilities to light, and they exhibit a specific refractive index under the combined action. This property may be of great significance in the identification and analysis of this substance.
    What are the chemical properties of 2-pyridinecarboxylic acid, 3-chloro-6- (trifluoromethyl) -
    The physical properties of 3 + -alkane-6- (triethylmethyl) -carboxylic acids are common in chemistry. Each of these compounds has its own characteristics, which are related to its chemical activity and stability.
    2 + -carboxylic acid, the carboxyl group is its key functional group. The carboxyl group is acidic and can neutralize with bases to form corresponding salts and water. For example, it can react with sodium hydroxide to obtain sodium carboxylate salt and water. This acid can also participate in esterification reactions, and alcohols can form esters and water under acid catalysis. This reaction is widely used in many fields such as fragrance and drug synthesis. < Br >
    3 + -alkane-6- (triethyl) -, the alkyl group in its structure imparts a certain hydrophobicity to the compound. The presence of alkyl groups makes this compound highly soluble in organic solvents, but less soluble in water. Its chemical stability is high, and it is not easy to react with common reagents under normal conditions. However, under high temperature, light or specific catalysts, free radical substitution reactions can occur, and hydrogen atoms on alkyl groups can be replaced by other atoms or groups.
    6- (triethyl) -In the structure, the steric resistance of triethyl groups is large, which affects the reactivity and spatial configuration of the compound. Due to the steric hindrance, the activity check point of some reactions may be hindered, resulting in a decrease in the reaction rate or a change in the reaction path. In stereochemistry, this spatial factor also has a significant impact on the configuration of the product.
    All these, the chemical properties of 2 + -carboxylic acid, 3 + -alkane-6- (triethylmethyl) - are rich and diverse, and are of great significance in the fields of organic synthesis, materials science, and drug development. According to their characteristics, scholars can skillfully design and synthesize the desired compounds.
    What are the synthesis methods of 2-pyridinecarboxylic acid, 3-chloro-6- (trifluoromethyl) -
    To prepare 2-carboxylic acid, 3-alkyne-6- (triethylmethyl), the synthesis method has the following methods:
    First, the reaction of alkynes and halogenated hydrocarbons can be recovered. First, take an appropriate alkyne and treat it with a strong base such as sodium amide (NaNH ²) to form an alkynyl negative ion, which has strong nucleophilicity. After encountering the halogenated hydrocarbon containing triethylmethyl, the alkynyl negative ion attacks the carbon-halogen bond of the halogenated hydrocarbon, and the halogen atom leaves, and then forms a compound containing alkynyl and triethylmethyl groups. After an appropriate oxidation step, a specific group can be converted into a carboxylic acid, thereby obtaining the target product.
    Second, the reaction of Grignard reagent is used. First, a halogenated hydrocarbon containing triethyl methyl is prepared, and it interacts with magnesium in a solvent such as anhydrous ether or tetrahydrofuran to generate the corresponding Grignard reagent. This Grignard reagent can react with alkyne derivatives with appropriate functional groups to form carbon-carbon bonds. Subsequent reactions such as oxidation modify the relevant groups to the desired carboxylic acid to achieve the purpose of synthesis.
    Third, it can be considered to pass through the intermediate of olefins. First, an olefin containing triethyl and a double bond is prepared by a suitable reaction, and then the double bond is functionalized. For example, the double bond is converted into an alcohol hydroxyl group by a borohydration-oxidation reaction, and then the alcohol hydroxyl group is oxidized to a carboxylic acid. The addition of triethyl and alkynyl moiety can gradually splice the molecular structure through the reaction of halogenated hydrocarbons and alkynes derivatives, or other carbon-carbon bond formation reactions, and finally synthesize the target 2-carboxylic acid, 3-alkynyne-6- (triethyl methyl) compound.
    Synthesis requires weighing the choice according to many factors such as the availability of raw materials, the difficulty of reaction conditions, and the high and low yield, and carefully designing the reaction route can be obtained efficiently.
    2-Pyridinecarboxylic acid, 3-chloro-6- (trifluoromethyl) - What is the price range in the market?
    Nowadays, there are dicarboxyl, trialkane, and hexadecyl (triethyl methyl) products. What is the price range in the market? This question is quite difficult to answer quickly. It is affected by various factors, such as the distance of origin, the age of prosperity, the difficulty of labor, and the supply and demand of the city.
    And the name of this dicarboxyl, trialkane, and hexadecyl (triethyl methyl) product is not detailed, and it is difficult to determine its quality and use, so the price is difficult to determine. If it is a product that is commonly available, produced in large quantities but used in small quantities, the price may be cheap, or only a few dollars a catty. If it is a rare and rare thing, difficult to harvest, and used by a large number of people, the price will be high, or even a thousand gold catties will not be known.
    And the price of the market is easy, which is not constant. In times of abundance, there are many things and the price is low; in times of famine, there are few things and the price is expensive. And in four places, prices are also different. Those who are cheap here or expensive elsewhere cannot be generalized. Therefore, if you want to know the price range of this dicarboxyl group, trialkane reduction, and six reduction (triethyl methyl) in the market, you need to carefully consider its nature, origin, and market conditions before you can get a more accurate price.