2-Pyridinecarboxamide,4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-

This is a 2-pyridineformamide compound, and its complete chemical structure is quite complex. Looking at its name, it can be seen that the main body is 2-pyridineformamide, which is connected with a large substituent at the 4 position. This substituent is composed of a series of fused rings and side chains. First, a furano [2,3-d] pyridazine ring is connected to the 4 position of the ring, and the 7 position is connected to a methylene group through an oxygen atom. This methylene group is connected to the 4 position of 2-pyridineformamide, and a methyl group is connected to the nitrogen atom of the formamide.
In the chemical structure of this compound, the pyridine ring is a six-membered nitrogen-containing heterocycle with aromatic properties, and the amide group - CONH - is connected to the second position of the pyridine ring, giving it a certain chemical activity and hydrogen bonding ability. Furano [2,3-d] pyridazine ring is fused from a furan ring and a pyridazine ring. This fused ring has a unique structure. In the 4-position p-ketaniline group, the chlorine atom has electron-absorbing properties, which will affect the distribution of molecular electron clouds, while the aniline group can participate in electron conjugation and further change the molecular chemical properties. The oxygen atom connected at the 7-position and the subsequent methylene form an ether bond structure, which is connected to the 4-position of pyridine formamide, making the molecular structure more complex The methyl group on the nitrogen atom changes the space environment and electron cloud density around the amide group.
In summary, this 2-pyridineformamide derivative may have potential applications in organic synthesis, medicinal chemistry and other fields due to its unique chemical structure, specific physicochemical properties and biological activities.

This is a chemical substance called 2-pyridineformamide, 4- [[4-[ (4-chlorophenyl) amino] furano [2,3-d] pyridazine-7-yl] oxy] methyl] -N-methyl -. Its physical properties are as follows:
concept, or in the form of white to off-white powder. This state is quite common in many chemical substances, and the powder is conducive to subsequent chemical reactions, such as dissolution, mixing, etc.
When it comes to solubility, in organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethyl formamide (DMF), it should have a certain solubility. The molecular structure of this substance contains many polar groups, which can interact with the polar molecules of organic solvents, such as hydrogen bonds, van der Waals forces, etc., to help it dissolve. However, in water, the solubility may be limited, because its structure is not highly hydrophilic, only some polar groups, and the overall hydrophobicity is strong.
In terms of melting boiling point, its melting point may be in a specific temperature range. Due to the existence of various forces between molecules, such as hydrogen bonds, van der Waals forces, etc., the molecules are arranged in an orderly manner, and it is necessary to reach a certain temperature to overcome these forces before melting. The boiling point is also affected by the intermolecular forces and the relative molecular mass. If the relative molecular mass is large and the intermolecular forces are strong, the boiling point will be higher.
In terms of density, there will be corresponding values due to the specific chemical structure and atomic composition. The density reflects the mass of a substance per unit volume, which has reference significance for its distribution and separation in different media.
In addition, the substance may have certain stability, but under specific conditions, such as high temperature, strong acid and alkali environment, and the presence of specific oxidizing or reducing agents, certain chemical bonds in the molecular structure may become active, causing chemical reactions to occur, resulting in changes in its structure and properties.
The physical properties of this chemical substance are crucial for its application in chemical synthesis, drug research and development, etc. According to its properties, researchers can rationally design experiments to achieve the expected reactions and functions.

This drug is called 2-pyridineformamide, 4- [[4 - [ (4-chlorophenyl) amino] furano [2,3 - d] pyridazine-7-yl] oxy] methyl] -N-methyl -. Its use is quite extensive and is often used in the field of pharmaceutical research and development.
In anti-tumor research, it shows unique potential. Studies have found that it can affect the signaling pathway of specific tumor cells. By precisely acting on protein targets closely related to proliferation and differentiation in tumor cells, it can effectively inhibit the abnormal proliferation of tumor cells, thereby providing a new strategy and hope for the treatment of cancer.
It is also involved in neurological diseases. Experiments have shown that it can regulate the release and metabolism of neurotransmitters. For example, the regulation of the level of key neurotransmitters such as dopamine and glutamate can improve the information transmission between nerve cells. It is expected to be used in the treatment and research of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. It helps to explore new treatment options and brings good news to patients.
In addition, it has also made its mark in the exploration of cardiovascular diseases. It can act on ion channels and receptors in the cardiovascular system, regulate the electrical activity and vascular tension of cardiomyocytes, and is of great significance for the treatment of cardiovascular diseases such as arrhythmia and hypertension. It provides new ideas and directions for the drug development of cardiovascular diseases.

To prepare 2-pyridineformamide, 4- [[4-[ (4-chlorophenyl) amino] furo [2,3-d] pyrizine-7-yl] oxy] methyl] -N-methyl, you can follow the following ancient method:
First take an appropriate amount of 4-chloroaniline, based on it, and react with a specific furanopyridazine derivative. This reaction requires a suitable solvent, such as dichloromethane, N, N-dimethylformamide, and an appropriate amount of base, such as potassium carbonate, triethylamine, etc., to assist the reaction. At the time of the reaction, control the temperature and duration, usually between room temperature and heating and reflux, for several times, so that the two can fully react to obtain an intermediate containing a specific structure.
Then react this intermediate with a reagent containing methoxy methyl group under appropriate conditions. This step also requires the selection of suitable solvents and catalysts, such as tetrahydrofuran as a solvent, potassium iodide as a catalyst, and when the reaction is heated up, the methoxy methyl group can be successfully connected to the intermediate to obtain another intermediate.
Finally, the new intermediate is reacted with N-methyl-2-pyridineformamide-related precursors, and this reaction may require a specific catalyst and a suitable solvent, such as a palladium catalyst, dioxane as a solvent, heating the reaction for several times, through a series of reaction steps, the final product is 2-pyridineformamide, 4 - [[4 - [ (4 - chlorophenyl) amino] furano [2,3 - d] pyridinezine-7 - yl] oxy] methyl] - N - methyl. After the reaction is completed, the product is purified by conventional separation and purification methods, such as column chromatography, recrystallization, etc., to obtain a pure product.

2-Pyridineformamide, 4- [[[4- [ (4-chlorophenyl) amino] furano [2,3-d] pyridazine-7-yl] oxy] methyl] -N-methyl, the chemical reactions related to this compound are mostly involved in the field of organic synthesis.
In the aromatization reaction, the amination of 4-chlorophenyl is a key step. In ancient theory, it is necessary to select suitable amination reagents, such as nitrogen-containing nucleophiles, and react with corresponding halides or activated intermediates under specific conditions. This reaction often requires the assistance of catalysts, such as metal catalysts and their ligands, to promote the substitution of chlorine atoms and amino groups on the aromatic ring to achieve the construction of the 4- [ (4-chlorophenyl) amino] part of the target structure.
The formation of furano [2,3-d] pyridazine structures, or through multi-step cyclization. This unique heterocyclic structure can be constructed by chain or cyclic precursors with suitable functional groups under acidic, basic or metal catalysis conditions. During cyclization, the reaction conditions need to be carefully adjusted to ensure the accuracy of cyclization check points and stereochemistry.
For the 4- [[[4- [ (4-chlorophenyl) amino] furo [2,3-d] pyridazine-7-yl] oxy] methyl] fraction in the compound, the formation of ether bonds is involved. Conventional methods often use hydroxyl-containing compounds to react with halogenated hydrocarbons or sulfonates in the presence of bases to form the desired ether bond structure through a nucleophilic substitution mechanism.
As for the N-methylation reaction, suitable methylation reagents, such as iodomethane, dimethyl sulfate, etc., can be selected to react with nitrogen-containing groups in an alkaline environment to introduce methyl groups to obtain N-methylation products. Throughout the synthesis process, each step of the reaction requires careful regulation of reaction temperature, time, reactant ratio and solvent conditions according to the characteristics of the compound, in order to obtain the target product efficiently and with high selectivity.