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What is the chemical structure of 2-Pyridinecarbonitrile, 4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -
This is a problem of organic compounds. To know the chemical structure of 2-pyridyl methylonitrile, 4- (4,4,5,5-tetramethyl-1,3,2-dioxyboron heterocyclopentane-2-yl). The structure of this compound has a formonitrile group at the 2nd position of the pyridine ring, and a 4,4,5,5-tetramethyl-1,3,2-dioxyboron heterocyclopentane-2-yl at the 4th position.
The pyridine ring is a six-membered nitrogen-containing heterocyclic ring with aromatic properties. Methylonitrile neocyanyl (-CN) is attached to the 2nd position of the pyridine ring. 4,4,5,5-tetramethyl-1,3,2-dioxyboron heterocyclopentane-2-yl, which is centered on boron atoms and forms a five-membered ring with two oxygen atoms. Two methyl groups are connected to each of the 4 and 5 positions on the ring, and the boron atom is connected to the 4 position of the pyridine ring.
Its structure can be imagined as a pyridine ring like a hexagonal building, with 2 positions extending the "antennae" of the formonitrile group, and 4 positions connecting 4, 4, 5, 5-tetramethyl-1,3,2-dioxyboron heterocyclopentane-2-yl "branch building". In the field of organic synthesis, this structure is often used as an important intermediate and participates in many reactions. Its boron heterocyclopentane structure can be transformed through specific reactions to achieve molecular construction and modification.
What are the physical properties of 2-Pyridinecarbonitrile, 4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -
2-Pyridyl-formonitrile, 4- (4,4,5,5-tetramethyl-1,3,2-dioxoborocyclopentane-2-yl) The physical properties of this compound are also very important and are related to many chemical applications.
The morphology of this compound is either solid under normal conditions, with a specific crystal structure. The appearance of the crystal form can be seen under the microscope, or it has a regular geometry and is arranged in an orderly manner. Its melting point is a key physical parameter, which can be used to determine the purity and characteristics after fine measurement. The molecular structure of the pyridine ring interacts with boron heterocyclopentane, and the melting point is in a specific range, which is an important indicator for identifying this substance.
Solubility is also a significant physical property. In organic solvents, such as common tetrahydrofuran and dichloromethane, because their molecular structures have a certain polarity, they can form a suitable force with the molecules of such solvents, so they are soluble. However, in water, due to the weak interaction between water molecules and the compound molecules, the solubility is poor.
Furthermore, its density cannot be ignored. Accurate determination of density helps to understand the degree of molecular packing compactness. The density value reflects the spatial arrangement of molecules and is closely related to the distance and interaction between molecules.
In addition, the color of the compound may be colorless to light yellow in its pure state. This color is derived from the absorption and reflection characteristics of the molecular structure to light. Intramolecular electron transition levels determine the absorption of light of different wavelengths, and unabsorbed light forms the color seen by vision.
This compound has unique physical properties, and in-depth investigation of it is of great significance in chemical synthesis, materials science and other fields, laying the foundation for many scientific research and industrial applications.
What is the main use of 2-Pyridinecarbonitrile, 4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -?
2-Pyridineformonitrile, 4- (4, 4, 5, 5-tetramethyl-1, 3, 2-dioxoboran-2-yl) This compound has a wide range of uses. It is a key reagent in the field of organic synthesis. It is often found in reactions that build carbon-carbon bonds, such as the Suzuki coupling reaction. In the Suzuki coupling reaction, it can efficiently couple with substrates such as halogenated aromatics or halogenated olefins in the presence of palladium catalysts and bases, and then form many complex aromatic compounds.
This compound also plays an important role in the development of many drugs. Due to the unique chemical activity and spatial structure of the pyridine and boron esters in its structure, it can be used as a key intermediate to assist in the synthesis of drug molecules with specific pharmacological activities, such as some innovative drugs used to treat specific diseases. By cleverly using its reactivity, the required molecular structure can be precisely built.
In the field of materials science, it also makes contributions. It can be used to prepare functional materials, such as optoelectronic materials. Due to its specific electronic structure and reactivity, it can participate in the material synthesis process, giving materials unique optical or electrical properties, such as enhancing the absorption or emission ability of materials to specific wavelengths of light, or improving the electrical conductivity of materials, thereby promoting the development of new optoelectronic materials.
What are the synthesis methods of 2-Pyridinecarbonitrile, 4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -
There are several common methods for the synthesis of 2-pyridyl-methylnitrile, 4- (4, 4, 5, 5-tetramethyl-1, 3, 2-dioxoboran-2-yl).
One is the Suzuki coupling reaction pathway. This reaction requires halogenated pyridyl-methylnitrile derivatives and 4, 4, 5, 5-tetramethyl-1, 3, 2-dioxoboran-2-yl borate as raw materials. First, halogenated pyridyl-methylnitrile derivatives, borate esters, bases and palladium catalysts are co-placed in suitable organic solvents. The effect of bases is to activate borate esters, making them easier to react with halogenated compounds. Palladium catalysts are the key to the reaction, promoting the fracture and recombination of carbon-boron bonds and carbon-halogen bonds. Commonly used bases, such as potassium carbonate, sodium carbonate, etc.; commonly used palladium catalysts, such as tetra (triphenylphosphine) palladium, etc. The reaction needs to be carried out under heating and inert gas protection to avoid catalyst poisoning and oxidation of raw materials and products. In this way, the coupling reaction between the two can be promoted to generate the target product 2-pyridinonitrile, 4- (4,4,5,5-tetramethyl-1,3,2-dioxaboronamyl-2-yl).
The second can be considered to be synthesized by the functional group conversion of the pyridine ring. First, a specific substituted pyridine derivative is prepared. The fourth position of the pyridine ring of this derivative needs to have a substituent that can be converted into a functional group. Then, through a series of chemical reactions, the substituent is converted into 4- (4,4,5,5-tetramethyl-1,3,2-dioxaboronyl-2-yl). For example, if the fourth position of the pyridine ring is a halogen atom, it can be reacted with magnesium to make a Grignard reagent, and then reacted with the corresponding borate ester. After a series of treatments, the target product can be obtained. In this process, the preparation of Grignard reagents requires an anhydrous and oxygen-free environment to prevent side reactions with water and oxygen.
Furthermore, the conversion of nitrile groups can also be used as an entry point. First synthesize pyridine derivatives containing 4- (4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl), and then convert functional groups at other positions on the pyridine ring into nitrile groups through suitable reactions. If halogenated pyridine derivatives can be used to react with cyanide reagents to introduce nitrile groups, this process should pay attention to the toxicity of cyanide reagents, and the operation should be carried out in a well-ventilated environment.
2-Pyridinecarbonitrile, 4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) - What are the relevant safety considerations?
2-Pyridinecarbonitrile, 4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) - is a compound commonly used in organic synthesis. In its experimental operation and use, there are many safety precautions to be paid attention to.
The first thing to pay attention to is fire prevention. This compound is mostly organic and flammable. In the experimental site, be sure to stay away from open flames and hot topics. Be careful when using high temperature equipment such as alcohol lamps and electric stoves. At the same time, appropriate fire extinguishing equipment, such as dry powder fire extinguishers, should be equipped for emergencies.
Antitoxin is also extremely critical. Although its exact toxicity is not known, organic compounds may be toxic to a certain extent. The operation should be carried out in a well-ventilated environment, such as a fume hood, to prevent inhalation of its volatile gases. If you accidentally come into contact with the skin or eyes, you should immediately rinse with plenty of water and seek medical attention in time.
Furthermore, the compound may have an impact on the environment. Experimental waste should not be discarded at will, and should be properly disposed of in accordance with relevant regulations to prevent pollution of soil, water sources and other environments.
In addition, in terms of storage, it should be placed in a cool, dry and ventilated place to avoid direct sunlight and moisture, so as to prevent deterioration from affecting the experimental effect. The access process should be accurate, avoid waste, and follow the laboratory standard process, so as to ensure the safety and smooth conduct of the experiment, and avoid danger and loss.