2-(Phenylmethyl)pyridine

2-%28Phenylmethyl%29pyridine is 2- (phenyl) pyridine, which is an organic compound, often called benzylpyridine. It has a wide range of uses and has important applications in many fields.
In the field of medicinal chemistry, benzylpyridine is often used as a key intermediate to synthesize drugs. Due to its unique chemical structure, it can participate in a variety of chemical reactions and help build complex drug molecular structures. With its structural properties, it can interact with specific targets in organisms, thereby giving drugs specific pharmacological activities.
In the field of materials science, it can be used to prepare materials with special properties. For example, in the synthesis of some organic optoelectronic materials, the introduction as a structural unit can effectively regulate the electrical and optical properties of the materials, thereby improving the performance of the materials in devices such as Light Emitting Diodes and solar cells.
In the field of organic synthetic chemistry, benzylpyridine is a key class of organic reagents. It can be used to perform various functional group conversion and carbon-carbon bond formation reactions, providing an effective path for the synthesis of complex organic molecules. It can participate in many reactions such as nucleophilic substitution, electrophilic substitution, and transition metal catalysis, providing rich strategies for organic synthesis chemists to construct target molecules.
In coordination chemistry, 2- (phenylmethylpyridine) can be used as a ligand to coordinate with metal ions to form metal complexes. These complexes often exhibit unique physical and chemical properties and have potential applications in catalysis, molecular recognition, and biomedicine. For example, some metal-benzylpyridine complexes can act as efficient catalysts for specific organic reactions, exhibiting high activity and selectivity.

2-%28Phenylmethyl%29pyridine is 2 - (phenylmethyl) pyridine, also known as benzylpyridine. Its physical properties are as follows:
In view, 2 - (phenylmethyl) pyridine is a colorless to light yellow liquid, which is clearly distinguishable under normal circumstances. It has a special odor, but it is not pungent and intolerable, but a unique fragrant smell.
In terms of its melting point, the melting point is about -70 ° C. It is a liquid at this low temperature, which shows its low freezing point. The boiling point is between 246 and 248 ° C. It needs a higher temperature to turn it into a gas state. < Br >
In terms of density, it is about 1.016 g/mL (25 ° C), which is slightly heavier than water. Therefore, in a system coexisting with water, 2 - (phenylmethyl) pyridine will sink to the bottom of the water.
In terms of solubility, it is insoluble in water, but easily soluble in many organic solvents, such as ethanol, ether, chloroform, etc. This property is due to the combination of its molecular structure and the force between organic solvent molecules, while the force between water molecules is weak, making it insoluble in water.
In addition, 2 - (phenylmethyl) pyridine has a certain volatility and will slowly evaporate into the air in an open environment. And its steam is heavier than air, allowing it to spread along the ground.

2-%28Phenylmethyl%29pyridine is 2 - (phenyl) pyridine, also known as benzylpyridine, its chemical properties are as follows:
In terms of view, 2 - (phenyl) pyridine is a colorless to light yellow liquid with a special odor and is stable at room temperature and pressure. Its density is slightly higher than that of water, about 0.99g/cm ³, boiling point is 246 - 248 ° C, melting point is -15 ° C. Because of the structure of pyridine ring and benzyl group, it has unique chemical activity.
In terms of reactivity, the nitrogen atom of the pyridine ring is electron-rich, basic, and can form salts with acids. In case of hydrochloric acid, the corresponding pyridine hydrochloride is formed. This property makes it a base catalyst in organic synthesis, promoting many reactions, such as ester hydrolysis, condensation reactions, etc.
Furthermore, the α-hydrogen of the benzyl moiety is active and can be substituted under appropriate conditions. Treated with halogenated reagents, α-hydrogen can be replaced by halogens to obtain α-halogenated products. This product is an important intermediate and can be introduced into other functional groups through nucleophilic substitution reactions.
In addition, the pyridine ring of 2- (benzyl) pyridine can undergo electrophilic substitution reactions. However, due to the electron absorption of nitrogen atoms, the reaction activity is lower than that of benzene, and the substitution mostly occurs at the 3 and 5 positions of the pyridine ring. For example, when mixed with nitric acid and sulfuric acid, 3-nitro-2- (phenyl) pyridine can be obtained.
At the same time, the compound can participate in the coupling reaction catalyzed by transition metals. Under the action of palladium, nickel and other catalysts, the carbon-halogen bond or carbon-oxygen bond of benzyl can be coupled with other organometallic reagents to construct carbon-carbon or carbon-hetero atomic bonds, which are widely used in the fields of drug synthesis and material preparation.
In summary, 2 - (phenyl) pyridine is an important raw material and intermediate for the synthesis of complex organic compounds due to its special structure and rich chemical properties.

2-%28Phenylmethyl%29pyridine that is, 2-benzylpyridine, there are many ways to synthesize this compound, the following is detailed:
1. ** Nucleophilic substitution method using pyridine and benzyl halide as raw materials **: Take pyridine and benzyl halide (such as benzyl chloride, benzyl bromide), under the catalysis of base, the two can initiate nucleophilic substitution reaction. Bases such as potassium carbonate and sodium carbonate can be used in organic solvents (such as N, N-dimethylformamide, acetonitrile), the nitrogen atom of pyridine nucleophilic attacks the benzyl carbon of benzyl halide, and the halogen ion leaves to obtain 2-benzylpyridine The reaction conditions are mild and easy to operate, but side reactions may also occur, such as the formation of multiple substitution products.
2. ** Condensation reaction using 2-methylpyridine and benzaldehyde as raw materials **: Under the action of basic catalysts (such as sodium ethyl alcohol and potassium tert-butyl alcohol), 2-methylpyridine and benzaldehyde are condensed to form an alkenal intermediate, and then hydrogenated and reduced to obtain 2-benzylpyridine. This route of raw materials is common and easy to obtain, but the reaction steps are slightly complicated, and the reaction conditions need to be controlled to ensure the stability of the intermediate product to improve the yield.
3. ** Transition metal catalyzed coupling reaction **: Use transition metal catalysts, such as palladium, nickel, etc., to catalyze the coupling reaction of halogenated pyridine with benzyl boronic acid or its esters. This kind of reaction has good selectivity and high yield. However, the catalyst cost is higher, the reaction conditions are demanding, inert gas protection is required, anhydrous and anaerobic environment, and the reaction equipment and operation technology are also demanding.
4. ** Reaction with pyridine N-oxide as raw material **: Pyridine is first converted into pyridine N-oxide, and then reacted with benzyl halide or benzyl alcohol. The activity of pyridine N-oxide is higher than that of pyridine, and it is easier to react with benzyl reagents, and then the oxygen is removed through the reduction step to obtain 2-benzylpyridine. This approach can avoid the interference of the basicity of pyridine nitrogen atoms on the reaction and improve the selectivity of the reaction, but the multi-step reaction increases the complexity of the operation, and each step needs to be carefully controlled.

There are many types of goods in the market, but it is very difficult to know the price of 2 - (phenylmethyl) pyridine. This compound may be difficult to predict due to its unique use, different quality, and changes in supply and demand.
If it is based on ordinary commercial reasons, if this chemical is used in ordinary industrial processes, the demand is quite large and the supply is sufficient, the price may be relatively easy. However, if it is used in high-end fields such as fine chemicals and pharmaceutical research and development, the purity and quality requirements are strict, and the preparation is not easy and the supply is scarce, the price will be high.
Looking at past market conditions, the price of similar chemicals often varies from time to time. Or when the raw materials are abundant and the craftsmanship is advanced, the price will decline; if the raw materials are scarce and the regulations are stricter, the price will rise.
As for 2 - (phenylmethyl) pyridine, although it is difficult to determine the upper and lower limits of its price, it is roughly deduced. If it is an industrial general product, it may cost tens of thousands of gold per ton or tens of thousands of gold; if it is a high-purity high-quality product for medical research, the price per gram may reach tens of gold or even hundreds of gold. This is the number of ideas. The actual price still needs to be carefully inspected by the market conditions and asked by merchants and brokers before the exact number can be obtained. The market is impermanent, and the price can not be determined temporarily. The real-time market shall prevail.