2-Phenyl-5-bromopyridine

2-Phenyl-5-bromopyridine is an important compound in organic chemistry. Its main uses are quite extensive.
First, in the field of medicinal chemistry, it is often a key intermediate. The synthesis of many drugs depends on its participation in reactions. Due to its unique chemical structure, specific functional groups can be introduced to build molecular frameworks with specific biological activities. Through chemical modification and transformation, drugs with therapeutic efficacy for specific diseases can be prepared. For example, for the development of drugs for certain inflammatory or neurological diseases, 2-phenyl-5-bromopyridine may play an important role in the synthesis pathway, enabling the synthesis of new drugs with better efficacy and lower side effects.
Second, it is also used in the field of materials science. It can be used as a starting material for the construction of new organic materials. After a series of reactions, materials with special optical and electrical properties can be prepared. For example, it is used in the synthesis of organic Light Emitting Diode (OLED) materials to give the material unique luminescence properties or improve its charge transfer ability, thereby improving the performance of OLED devices, such as luminous efficiency and stability.
Third, it is a commonly used synthetic building block in organic synthetic chemistry. Chemists can use the reactivity of its bromine atom and phenyl group to carry out various classic organic reactions, such as Suzuki coupling reaction, Negishi coupling reaction, etc. Through these reactions, complex organic molecular structures can be constructed, the diversity of organic compounds can be expanded, and an important material basis and means for the development of organic synthetic chemistry can be provided.
In conclusion, 2-phenyl-5-bromopyridine, with its unique structure and reactivity, plays an important role in many fields such as medicinal chemistry, materials science and organic synthetic chemistry, and is of great significance to promote research and development in related fields.

The synthesis method of 2-phenyl-5-bromopyridine has been investigated by many scholars in the past, and the following common methods are briefly described.
First, pyridine is used as the starting material. The bromine atom is introduced before the 5-position of pyridine, which can be obtained by electrophilic substitution reaction with suitable brominating reagents, such as liquid bromine, in the presence of suitable catalysts, such as iron powder or iron tribromide, so that the bromine atom replaces the hydrogen atom of the 5-position of pyridine to obtain 5-bromopyridine. Then, 5-bromopyridine and phenyl halide, such as bromobenzene, are introduced into the phenyl group at the 2-position of 5-bromopyridine through the Buchwald-Hartwig coupling reaction under the condition of palladium catalysis and the presence of a base, and the final product is 2-phenyl-5-bromopyridine. Although this pathway step is relatively clear, the reaction conditions of each step need to be carefully regulated to improve the yield and selectivity.
Second, phenylboronic acid and 5-bromopyridine are used as raw materials. The 2-position halogen atom of 5-bromo-2-halopyridine can directly form a carbon-carbon bond with phenylboronic acid under the action of palladium catalyst and base through Suzuki coupling reaction, so as to obtain the target product 2-phenyl-5-bromopyridine. This method has relatively mild reaction conditions and good tolerance to functional groups, but the acquisition of raw material 5-bromopyridine may require some steps.
Third, there are also those who use 2-phenylpyridine as the starting material. 2-Phenyl-5-bromopyridine is synthesized by the bromination reaction of 2-phenylpyridine first, and the bromine atom is selectively introduced into the 5-position through proper selection of brominating reagents and reaction conditions. This approach requires attention to the regioselectivity of the bromination reaction to ensure the purity of the product.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, reaction conditions, cost and purity of the target product.

2-Phenyl-5-bromopyridine is an organic compound. Its physical properties are particularly important and are of significance in various fields such as chemical industry and medicine.
First word appearance, this substance is usually white to light yellow crystalline powder, with fine texture and stability under normal conditions. Looking at its color, the pure color is white, if it contains some impurities, or a slight yellowish tone, this is a significant feature of its appearance and can be directly identified by the naked eye.
Second, on the melting point, its melting point is in a specific temperature range, about [specific melting point range]. Melting point is one of the properties of the substance, and its purity can be identified by accurately measuring the melting point. If the sample purity is high, the melting point is sharp and close to the theoretical value; if it contains impurities, the melting point will drop and the melting range will increase.
The boiling point is also a key physical property. Under specific pressure conditions, the boiling point of 2-phenyl-5-bromopyridine is about [specific boiling point value]. The boiling point reflects the temperature at which a substance changes from liquid to gaseous state, which is related to its state change under different temperature environments.
In terms of solubility, its solubility varies in organic solvents. In common organic solvents such as ethanol and chloroform, it has a certain solubility and can be uniformly dispersed to form a solution. This property makes it easy to select suitable solvents in organic synthesis reactions to facilitate the reaction. However, in water, its solubility is very small, because its molecular structure contains hydrophobic phenyl and pyridine rings, resulting in weak interaction with water molecules.
Density is also a consideration point, about [specific density value]. Density reflects the mass of the substance per unit volume and is an important parameter in material separation, purification and process design.
In addition, 2-phenyl-5-bromopyridine has a certain vapor pressure. At a given temperature, some molecules escape from the liquid surface to cause pressure in the vapor phase. Although this vapor pressure is low, it has an impact on its diffusion and volatilization in the environment. Pay attention when storing and using.

2-Phenyl-5-bromopyridine is on the market, and its price range is difficult to determine. The impact of the price of this compound is related to many ends. First, the purity is the heaviest, and the price of high purity is high, because the purification process is complex and expensive. If the purity reaches a very high level, it is close to scientific research grade, and the price will be high; if it is used in general industry, the purity will be slightly reduced, and the price may also be reduced. Second, the supply and demand conditions affect its price. If there are many people seeking it at a time, but the production is insufficient, the price will rise; if the supply exceeds the demand, the price may decline. Third, the difficulty of preparation also involves the price. If the synthesis method is complicated, the materials used are rare, and the cost will be high, the price will also follow.
Looking at the past examples of chemical transactions, the price of such organic compounds varies greatly due to different uses and purity. For ordinary chemical synthesis, the price per gram or tens of yuan; if it is for high-purity scientific research, the price per gram can reach hundreds or even hundreds of yuan. And the market is fickle, and the fluctuation of raw material prices, process innovation, and policy regulation can all cause their price fluctuations. Therefore, to know the exact price, you need to consult chemical raw material suppliers and compare the quotations of different merchants to clarify their current price range.

For 2-phenyl-5-bromopyridine, there are many matters to be paid attention to during storage and transportation.
The first to bear the brunt, the properties of this substance are related to storage and transportation. Its chemical structure contains benzene rings and pyridine rings, and bromine atoms are also among them. In view of its chemical properties, it must be stored in a cool, dry and well-ventilated place. If it is placed in a high temperature and humid place, it may cause chemical reactions to occur, which will damage its quality. High temperature can enhance its molecular activity, or trigger reactions such as decomposition and polymerization; in a humid environment, moisture may interact with the substance, causing it to deteriorate.
Furthermore, packaging is also crucial. When tightly sealed with suitable materials to prevent leakage. Commonly used packaging materials, such as glass bottles, plastic bottles or special metal containers, need to be selected according to their specific properties. If it is corrosive to some materials, avoid the corresponding materials. In case of leakage, not only waste this material, but also endanger the environment and personal safety.
During transportation, also pay attention to the control of temperature and vibration. Excessive temperature fluctuations may affect its stability; excessive vibration may cause damage to the packaging and cause leakage. And the means of transportation need to be clean and free of impurities to avoid mutual contamination with the substance and affect its purity.
At the same time, transportation and storage personnel should be familiar with the properties, hazards and emergency treatment of 2-phenyl-5-bromopyridine. In case of emergencies, such as leakage, fire, etc., they can respond quickly and appropriately to reduce losses and hazards.