2 Phenyl 3 Cyanopyridine
pyridine pyrrole pyrazine piperidine piperazine

2-phenyl-3-cyanopyridine

    Specifications

    HS Code

    401125

    Chemical Formula C12H8N2
    Molecular Weight 180.205 g/mol
    Appearance Solid
    Solubility In Water Insoluble (due to non - polar nature of phenyl group and relatively hydrophobic nature of the molecule)
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, toluene
    Odor Odorless (in pure form, typical for many aromatic heterocyclic compounds)
    Stability Stable under normal conditions, but may react with strong oxidizing agents

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    General Information
    Where to Buy 2-phenyl-3-cyanopyridine in China?
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    Frequently Asked Questions

    As a leading 2-phenyl-3-cyanopyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-phenyl-3-cyanopyridine?
    2-Phenyl-3-cyanopyridine, which has a wide range of uses. In the field of medicine, it is often a key intermediate and can be used to prepare a variety of drugs. For example, some compounds with specific physiological activities rely on it as the starting material for synthesis. After a series of reactions, complex structures are constructed to achieve the purpose of treating diseases.
    In the field of material chemistry, it also plays an important role. It can participate in the preparation of organic materials with special properties. Its structure endows the material with unique optical and electrical properties, and is used in optical displays, electronic devices and other fields, or to improve material stability, solubility and other properties. < Br >
    In the field of organic synthesis, it is a commonly used building block. With its special functional groups, it reacts with other reagents through many organic reactions, such as nucleophilic substitution, electrophilic substitution, etc., to extend the carbon chain and introduce new functional groups, synthesize organic compounds with diverse structures, expand the types and properties of organic compounds, and promote the development of organic synthesis chemistry. In short, 2-phenyl-3-cyanopyridine has important uses in many fields such as medicine, materials, and organic synthesis, and is an indispensable substance for the development of chemical-related industries.
    What are the physical properties of 2-phenyl-3-cyanopyridine?
    2-Phenyl-3-cyanopyridine is one of the organic compounds. Its physical properties are worthy of detailed investigation.
    Looking at its appearance, it often shows a white to light yellow crystalline powder, which is visible to the eye. Its melting point is about 122-126 ° C. The determination of the melting point is related to the temperature node of the thermal phase transformation of the substance. This characteristic plays a key role in the identification and purity judgment of the substance.
    In terms of solubility, 2-phenyl-3-cyanopyridine has a certain solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), and dimethyl sulfoxide (DMSO). However, in water, its solubility is very small. The difference in solubility is due to the different structure of the compound itself and the interaction between water molecules and organic solvent molecules. The molecular structure of the organic solvent, or the interaction with 2-phenyl-3-cyanopyridine, is dispersed by van der Waals force, hydrogen bonds, etc.; while the polar structure of the water molecule interacts weakly with the compound, so it is difficult to dissolve.
    Furthermore, the density of the compound is about 1.22 g/cm ³. The density is also the mass per unit volume of the substance. This value reflects the relationship between its mass and volume. It is an important parameter in many fields such as chemical production and material separation.
    In addition, its vapor pressure is very low, indicating that under normal temperature and pressure, it has a weak tendency to transform from solid or liquid to gaseous. This property also needs to be taken into account during storage and transportation. Because it is not easy to volatilize, there is no need to worry too much about losses due to volatilization during storage. However, it is also necessary to pay attention to factors such as environmental temperature and humidity to prevent its physical state from changing.
    2-phenyl-3-cyanopyridine chemical synthesis methods
    To prepare 2-phenyl-3-cyanopyridine, there are three methods. First, 2-phenyl-3-cyanopyridine is used as the starting material, 2- (bromomethyl) pyridine is obtained by bromination, and then it is heated with sodium cyanide, nucleophilic substitution, cyano-entry, to obtain the target. The raw materials are easy to obtain in this way, but the bromination step requires controlled conditions to prevent polybromination. Second, phenylboronic acid and 3-cyanopyridine-2-formaldehyde are used as materials and prepared by Suzuki coupling reaction. Palladium is used as the catalyst, and the base is the auxiliary agent, and the two are coupled to form a bond. The method has good selectivity and high yield, but the catalyst palladium is expensive, resulting in higher cost. Third, it starts with o-amino acetophenone and malonononitrile, and is formed by condensation and cyclization under appropriate catalysis and heating. The steps in this way are simple, and the raw materials are common, but the reaction conditions may need to be fine-tuned to achieve yield. Each way has advantages and disadvantages. When implementing, it should be selected according to the availability of raw materials, the cost, and the yield.
    What is the price range of 2-phenyl-3-cyanopyridine in the market?
    I haven't heard of the exact price of 2-phenyl-3-cyanopyridine in the market, but if you want to estimate its price, you need to consider various factors. The difficulty of synthesizing this compound, if its synthesis requires difficult steps, rare raw materials or harsh conditions, the price will be high. And the amount of demand is also the key. If the demand in the pharmaceutical, chemical and other industries is strong, the price may be considerable; if the demand is small, the price will not be high. Furthermore, the competition in the market also has an impact. If there are many producers and the competition is intense, the price may stabilize and decline; if there are few suppliers, it will have a monopoly, and the price will rise.
    In the past, this kind of compound was slightly easier to synthesize and the raw materials were common, and the price per gram was from a few yuan to tens of yuan. If the synthesis is difficult and the raw materials are rare, the price per gram can reach 100 yuan or even higher. However, 2-phenyl-3-cyanopyridine, without knowing the details of its synthesis, demand situation and market competition, it is difficult to determine the price range. Generally speaking, if the synthesis is not extremely difficult and the demand is not extremely strong, the price per gram may be between a few dozen yuan and a hundred yuan; if the synthesis is extremely difficult and the demand is extremely high, the price may exceed a hundred yuan, or even higher. But these are all speculative numbers, and the actual price still needs to be carefully considered. Changes in market conditions and supply and demand.
    What are 2-phenyl-3-cyanopyridine storage conditions?
    2-Phenyl-3-cyanopyridine is also a chemical substance. Its storage is essential, related to safety and quality storage, and cannot be ignored.
    This substance should be stored in a cool and dry place. Cover a cool environment to reduce its change due to heat, and avoid its chemical activity due to hyperthermia, decomposition or other adverse reactions. Dry places can prevent it from being damp, water or hydrolysis, etc., and damage its purity and characteristics.
    and must be placed in a well-ventilated place. With good ventilation, it can remove its escape gas and avoid its accumulation and danger. It should also be kept away from fires and heat sources. Open flames and high temperatures can cause them to explode. This is a big taboo.
    Storage places, the container must also be carefully selected. When using a sealed device, ensure that it does not come into contact with outside air, water vapor, etc. The material should be adapted and not chemically react with the substance to protect its quality.
    Furthermore, it must be stored separately with oxidants, acids, bases, etc. This number may react violently with 2-phenyl-3-cyanopyridine, endangering safety. The storage area should be equipped with suitable materials to deal with the leakage in case. In this way, 2-phenyl-3-cyanopyridine must be properly stored to maintain its quality and protect its safety.