2-[N,N-Bis(trifluoromethylsulfonyl)amino]-5-chloropyridine

2-%5BN%2CN-Bis%28trifluoromethylsulfonyl%29amino%5D-5-chloropyridine is an organic compound with a unique chemical structure and has applications in many important fields.
In the field of medicinal chemistry, it is often used as a key intermediate. Drug research and development aims to create compounds with specific biological activities that can precisely act on targets in the body. This compound may participate in specific chemical reactions due to its unique structure, which helps to build a complex drug molecular skeleton. For example, when developing new drugs for the treatment of specific diseases, it may be chemically modified to introduce other active groups, so that the new drug has better pharmacological properties, such as higher bioavailability, stronger target affinity, and lower toxic and side effects.
In the field of materials science, its application is also extensive. With the development of science and technology, the demand for new materials is increasing. This compound may be used as a synthetic raw material for functional materials. For example, in the preparation of organic optoelectronic materials, through rational molecular design and synthesis, the material may be endowed with special optoelectronic properties, such as good fluorescence properties, high-efficiency carrier transport ability, etc., for the manufacture of organic Light Emitting Diodes (OLEDs), solar cells and other optoelectronic devices, to improve device performance and efficiency.
In the field of pesticide chemistry, it also plays an important role. Pesticide research and development requires the creation of compounds with high activity against pests and environmental friendliness. This compound may exhibit biological activity against specific pests, pathogens and other pests due to its structural characteristics. Or it can be used as a lead compound to develop new and efficient pesticides through structural optimization, which can help control pests and diseases in agricultural production and ensure crop yield and quality.

To prepare 2 - [N, N - bis (trifluoromethylsulfonyl) amino] -5 -chloropyridine, there are several methods for its synthesis. One method is to take 5-chloropyridine-2-amine as the starting material. The raw material is reacted with trifluoromethylsulfonyl chloride in a suitable solvent in the presence of a base. Among the solvents, dichloromethane and the like can be selected, and the base can be triethylamine. During the reaction, trifluoromethylsulfonyl chloride is replaced with the amino group in 5-chloropyridine-2-amine, and the target product is gradually formed. < Br >
Another method starts with 2-chloro-5-nitropyridine. The nitro group is first reduced to an amino group, which can be achieved in a hydrogen environment by catalytic hydrogenation, using palladium carbon as a catalyst. Then the obtained 2-chloro-5-aminopyridine reacts with trifluoromethanesulfonyl chloride under reaction conditions similar to the above, that is, when a suitable solvent and a base are present, the product can also be obtained.
Furthermore, 2-hydroxy-5-chloropyridine can also be used as a starting material. First, the hydroxyl group is converted into a leaving group, such as reacting with p-toluenesulfonyl chloride to form a corresponding sulfonate. Subsequently, the sulfonate is reacted with N, N-bis (trifluoromethylsulfonyl) amine salt under basic conditions, and nucleophilic substitution is performed to obtain 2- [N, N-bis (trifluoromethylsulfonyl) amino] -5 -chloropyridine. Each method has its advantages and disadvantages, and it needs to be carefully selected according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the purity of the product.

2-% 5BN% 2CN-bis (trifluoromethylsulfonyl) amino% 5D-5-chloropyridine, this is an organic compound. Its physicochemical properties are quite important, related to its application in various fields.
First of all, physical properties. At room temperature, this substance may be in a solid state. As for the exact physical form, such as the shape and color of the crystal, it depends on the degree of refinement and specific preparation conditions. However, generally speaking, organic compounds containing such complex substituents are mostly white to light yellow solids. Its melting point and boiling point are also key physical parameters. Contains multiple fluorine atoms and sulfonyl groups, resulting in complex intermolecular forces, so the melting point may be higher. Due to the high electronegativity of fluorine atoms, and the sulfonyl group can participate in the weak interaction between molecules, making the intermolecular binding more tightly. The same is true for boiling point, or a higher temperature is required to vaporize it.
Re-discussion of chemical properties. The pyridine ring is aromatic, and its nitrogen atom imparts a certain alkalinity to the ring, which can react with acids to form salts. The 2-position N, N-bis (trifluoromethylsulfonyl) amino substituent, due to the strong electron-absorbing effect of trifluoromethyl and the conjugation effect of sulfonyl groups, greatly affects the distribution of the electron cloud of the pyridine ring, so that the electron cloud density of the pyridine ring decreases, and the activity of the electrophilic sub The 5-position chlorine atom, although also an electron-withdrawing group, can participate in the nucleophilic substitution reaction. Under appropriate conditions, the chlorine atom can be replaced by nucleophilic reagents, such as alkoxides, amines and other nucleophilic reagents can react with it to generate new derivatives and broaden its application in the field of organic synthesis.
Its solubility also needs attention. Because it contains multiple polar groups and fluorine atoms, it may have good solubility in polar organic solvents such as dichloromethane, N, N-dimethylformamide, but poor solubility in water. This is related to molecular polarity and the ability to interact with water molecules.
In conclusion, the physicochemical properties of 2-% 5BN% 2CN-bis (trifluoromethylsulfonyl) amino% 5D-5-chloropyridine are determined by its molecular structure and determine its application prospects in organic synthesis, materials science and other fields.

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2-%5BN%2CN-Bis%28trifluoromethylsulfonyl%29amino%5D-5-chloropyridine is a compound that has attracted much attention in the field of organic synthesis. It plays a key role in the preparation of many fine chemical products such as medicines and pesticides. Because of its unique structure, it is often used as an important intermediate in the synthesis of specific active molecules.
In today's chemical industry, many companies are involved in the production of this compound. Foreign companies such as Sigma-Aldrich have always been famous for providing high-quality chemical reagents. In its rich product line, there are 2-%5BN%2CN-Bis%28trifluoromethylsulfonyl%29amino%5D-5-chloropyridine. With its deep technical accumulation and strict quality control system, the company produces this compound in the global scientific research and industrial users.
And the domestic situation should not be underestimated. For example, BELINGWEI Technology Co., Ltd. has long focused on the supply of chemical reagents and intermediates. It has formed a mature process for the production of 2-%5BN%2CN-Bis%28trifluoromethylsulfonyl%29amino%5D-5-chloropyridine, and the product quality is stable, which can better meet the needs of the domestic market. There are also some small enterprises focusing on fine chemicals. Although the scale is not as large as the above companies, they also occupy a place in the production of 2-%5BN%2CN-Bis%28trifluoromethylsulfonyl%29amino%5D-5-chloropyridine with their flexible business strategies and deep cultivation in specific fields. These enterprises have gradually emerged in the market by continuously optimizing the production process and improving product quality.
In addition, with the continuous development of the chemical industry and the dynamic changes in market demand, some emerging enterprises have also begun to get involved in the production of 2-%5BN%2CN-Bis%28trifluoromethylsulfonyl%29amino%5D-5-chloropyridine. With their innovative technical concepts and efficient operation models, they have injected new vitality into the field, making the production pattern of 2-%5BN%2CN-Bis%28trifluoromethylsulfonyl%29amino%5D-5-chloropyridine more diversified.