2-(N-BOC-Amino)-5-Bromopyridine

2-%28N+-+BOC+-+Amino%29-5+-+Bromopyridine, that is, 2 - (N - BOC - amino) - 5 - bromopyridine, this substance has a wide range of uses. In the field of organic synthesis, it is a key intermediate. Gap can participate in a variety of chemical reactions because of its pyridine ring and the specific groups connected.
In the field of medicinal chemistry, it can be used to construct the skeleton of drug molecules. Through the reaction of its bromine atom with reagents containing specific functional groups, it can introduce key pharmacoactive groups, and then create new compounds with specific biological activities, which is of great significance in the process of drug development.
In the field of materials science, its structural units can be introduced into polymer materials through specific reactions. With its characteristics, it can improve the photoelectric properties and thermal stability of materials, etc., or endow materials with special identification and response properties for the preparation of functional materials.
In addition, in the synthesis of fine chemicals, it can be used as a starting material to generate high-value-added fine chemicals through multi-step reactions, such as special catalysts, ligands, etc., which are indispensable in the chemical production process.

To prepare 2 - (N - BOC - amino) - 5 - bromopyridine, the method is as follows:
First, 5 - bromopyridine - 2 - amine is taken as the starting material, with Boc 2O O as the protective reagent, organic bases such as triethylamine, etc., in suitable organic solvents such as dichloromethane, temperature-controlled reaction. Among them, Boc 2O O and the amino nucleophilic substitution of 5 - bromopyridine - 2 - amine form 2 - (N - BOC - amino) - 5 - bromopyridine, which is then purified by washing, drying, column chromatography and other methods.
It can be started from 2-amino-5-bromo-pyridine, using di-tert-butyl dicarbonate as the BOC source, under mild conditions, such as room temperature or slightly warming, in a polar aprotic solvent, an appropriate amount of alkali catalysis is added to promote its amino BOC protection to obtain the target product, which needs to be isolated and purified later.
Furthermore, a multi-step reaction route can be designed, first modifying the pyridine ring, introducing bromine atoms, and then performing BOC protection of amino groups. Then, it is necessary to carefully control the reaction conditions and intermediate inspection purity to achieve a high yield and purity of 2- (N-BOC-amino) -5-bromopyridine.

2 - (N - BOC - amino) - 5 - bromopyridine is a key intermediate in organic synthesis. This compound has the following physicochemical properties:
Looking at its appearance, under room temperature and pressure, it is mostly white to white solid, which is conducive to its operation and reaction in most common organic solvents. In terms of solubility, it exhibits good solubility in organic solvents such as dichloromethane, chloroform, N, N - dimethylformamide (DMF), and can be uniformly dispersed in these solvents, thus participating in various chemical reactions efficiently. However, it has little solubility in water, mainly due to the fact that hydrophobic pyridine rings and BOC protecting groups dominate its molecular structure, greatly reducing its ability to interact with water molecules.
When it comes to melting point, its melting point varies slightly due to different preparation methods and purity, and is roughly in a specific temperature range. This melting point data is of great significance for determining the purity of the compound and controlling the reaction conditions during the synthesis process. For example, in purification steps such as recrystallization, melting point is a key reference index, which can help experimenters determine whether the purity of the product is up to standard.
In terms of chemical stability, under conventional storage conditions, if it is far away from strong oxidants, strong acids, strong bases, etc., 2- (N-BOC-amino) -5-bromopyridine can remain relatively stable. However, the bromine atoms on its pyridine ring are active, and under specific conditions, nucleophilic substitution reactions are prone to occur, such as with active nucleophilic reagents, such as amines, alcohols, etc. Under appropriate alkali catalysis and temperature conditions, bromine atoms can be replaced by nucleophilic reagents to generate a series of derivatives, thus laying the foundation for the construction of organic compounds with diverse structures. The BOC protecting group on the amino group can be removed under acidic conditions, restoring free amino groups, creating conditions for further reactions with other functional groups.

2-%28N+-+BOC+-+Amino%29-5+-+Bromopyridine is 2- (N - BOC - amino) - 5 - bromopyridine. Many things need to be paid attention to when storing and transporting this substance.
Its chemical properties are active and sensitive to environmental factors. First of all, storage should be placed in a cool, dry and well ventilated place. Because of its fear of moisture, high air humidity can easily cause adverse reactions such as hydrolysis, which will damage its purity and quality. Temperature also needs to be strictly controlled. Excessive temperature may cause changes such as decomposition and polymerization, so it is generally appropriate to store at low temperature. The common temperature range is 2-8 ° C. At the same time, it should be kept away from fire and heat sources, because it may be flammable, and it may be dangerous to encounter open flames, hot topics or.
Furthermore, when storing, it should be stored separately from oxidants, acids, alkalis, etc., to avoid mixed storage to prevent violent chemical reactions. And ensure that the storage container is well sealed to prevent it from evaporating and escaping, polluting the environment or causing safety hazards.
As for transportation, the same cannot be taken lightly. Appropriate packaging materials need to be selected to ensure that the packaging is tight, can resist vibration, collision and friction, and prevent material leakage caused by container damage. During transportation, it is still necessary to maintain suitable temperature and humidity conditions and avoid direct sunlight. Transportation vehicles should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. In the event of an accident, they can respond in time. Transportation personnel also need professional training, familiar with the characteristics of the substance and emergency treatment methods, and regularly check the condition of the goods during transportation to ensure transportation safety.

There is a question today, what is the market price of 2 - (N - BOC - amino) - 5 - bromopyridine. This compound may have its uses in chemical synthesis and other fields. However, if you want to know its market price, you need to check the market situation in detail.
Looking at the previous "Tiangong Kaiwu", although it is not mentioned in this product, the production, sales and price of it vary from time to time and from place to place. The price of 2 - (N - BOC - amino) - 5 - bromopyridine, or so.
First, the price varies with the price of the raw material. If the price of the raw material used in the synthesis of this product rises, the price may also rise. If the required pyridine, bromide and BOC-related reagents are prepared, if their market prices rise or fall, the cost of the substance will be affected, and then its selling price will change.
Second, the supply and demand trend is related to the price. If the demand for 2- (N-BOC-amino) -5-bromopyridine increases sharply in the market, and the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price may fall. For example, when the demand for pharmaceutical research and development suddenly increases, the production does not keep up in time, and the price will rise.
Third, the price varies depending on the region. In places where the chemical industry gathers, production is convenient, transportation costs are low, and the price may be lower than elsewhere. In remote places, due to the superposition of transportation and other costs, the price may be higher.
Fourth, the advantages and disadvantages of the production process are also related to the price. If the new process can reduce the cost and yield, the price of the product may decrease due to the cost reduction.
In short, in order to determine the current market price of 2- (N-BOC-amino) -5-bromopyridine, it is advisable to consult chemical raw material suppliers, check the chemical product trading platform, and constantly observe the market dynamics in order to obtain a more accurate price.