2-(methylsulfanyl)pyridine-3-carboxylic acid

2-% (methylsulfanyl) pyridine-3-carboxylic acid, the Chinese name is often 2 - (methylsulfanyl) pyridine-3-carboxylic acid. This substance has unique chemical properties.
Its properties are mostly crystalline and stable at room temperature. When it encounters hot topics, open flames, or strong oxidants, it is easy to initiate chemical reactions.
When it comes to solubility, it can exhibit good solubility in organic solvents such as ethanol and acetone, but in water, the degree of solubility is quite limited. This property is due to its molecular structure, which includes both carboxyl groups with a certain polarity and non-polar pyridine rings and methylthio groups, so the dissolution behavior varies in different solvents.
In terms of acidity, the presence of carboxyl groups makes the substance acidic to a certain extent. In aqueous solution, carboxyl groups can be partially ionized, releasing hydrogen ions, and then exhibiting acidic characteristics. Its acidity is affected by the other groups in the molecule, and the electronic effect of pyridine ring and methylthio group can regulate the acidity of carboxyl groups. The electron-absorbing effect of pyridine ring can enhance the acidity of carboxyl groups; the electron-giving effect of methylthio group will weaken the acidity of carboxyl groups.
In terms of chemical reactivity, carboxyl groups can participate in many common reactions. For example, under acid-catalyzed conditions, esterification reactions with alcohols can occur to generate corresponding ester compounds. In addition, carboxyl groups can also neutralize with bases to form carboxylic salts. As a nitrogen-containing heterocycle, the nitrogen atom of the pyridine ring can participate in nucleophilic substitution reactions or coordinate with metal ions to form metal complexes. Methylthio groups also have their own unique reactivity and can participate in oxidation reactions to convert into sulfoxides or sulfones. The chemical properties of 2 - (methylthio) pyridine - 3 - carboxylic acids are determined by their molecular structure, and have important application value in organic synthesis, medicinal chemistry and other fields due to these properties.

2-% (methylsulfanyl) pyridine-3-carboxylic acid, that is, 2-methylthiopyridine-3-carboxylic acid, the common synthesis method is as follows:
The starting material is mostly 2-chloropyridine-3-carboxylic acid or 2-bromopyridine-3-carboxylic acid. These two can undergo nucleophilic substitution reaction with methyl mercaptan salt. The sulfur atom in methyl mercaptan salt has good nucleophilicity and can effectively attack the carbon atom connected to the halogen in halogenated pyridine. The halogen ion leaves, and the target product is obtained. For example, when 2-chloropyridine-3-carboxylic acid is reacted with sodium methanethiol in a suitable solvent, such as N, N-dimethylformamide (DMF), at an appropriate temperature (such as 60-80 ° C), 2-methylthiopyridine-3-carboxylic acid is formed in the reaction system after several hours. After the reaction is completed, the reaction solution is often diluted with water, then extracted with an organic solvent, and the product is purified by drying, distillation, etc.
Others use 2-hydroxypyridine-3-carboxylic acid as the starting material. It is first reacted with methylating reagents, such as dimethyl sulfate, under basic conditions to convert the hydroxyl group to methoxy group. Then, treated with thioreagents, such as phosphorus pentasulfide or Lawesson reagents, the methoxy group is replaced by methylthio group, and 2-methylthiopyridine-3-carboxylic acid can also be obtained. In this process, the control of alkaline conditions, the adjustment of reaction temperature and time are crucial, which are related to the reaction yield and product purity. If methylated with dimethyl sulfate, the amount of base needs to be precisely controlled, and too much or too little may affect the reaction process.
Furthermore, using pyridine as the starting material, first through halogenation reaction, such as reaction with chlorine or bromine under appropriate catalyst and conditions, the halogen atom is introduced at the 2nd position of the pyridine ring. Then through carboxylation reaction, the carboxyl group is introduced at the 3rd position, and the commonly used reagents such as carbon dioxide are combined with suitable metal reagents (such as Grignard reagent). Finally, it is reacted with methyl mercaptan to complete the introduction of methylthio groups, thereby preparing 2-methylthiopyridine-3-carboxylic acid. This route has many steps, and the reaction conditions of each step need to be carefully adjusted to ensure the smooth progress of each step of the reaction and high yield, so that the target product can be synthesized efficiently.

2-% (methylsulfanyl) pyridine-3-carboxylic acid, that is, 2- (methylsulfanyl) pyridine-3-carboxylic acid, is used in many fields.
In the field of medicine, it is a key organic synthesis intermediate. It can be subtly transformed into compounds with unique pharmacological activities through specific chemical reactions. After research, it is found that some of the substances synthesized from this as raw materials have potential value in the treatment of specific diseases. For example, in the process of developing new antibacterial drugs, the molecular structure of 2- (methylsulfanyl) pyridine-3-carboxylic acid can effectively interfere with the metabolic process of bacteria, thereby inhibiting the growth and reproduction of bacteria, providing a new way to solve the antibacterial problem.
In the field of pesticides, it also plays an important role. Based on it, a variety of pesticide products can be carefully designed and synthesized. Such pesticides show good control effects on pests, and their mechanism of action may damage the nervous system of pests or interfere with their growth and development process. For example, in farmland, spraying pesticides containing this ingredient can significantly reduce the damage of pests to crops, ensure crop yield and quality, and lay the foundation for agricultural harvest.
In the field of materials science, 2- (methylthio) pyridine-3-carboxylic acids can participate in the material modification process due to their special chemical structure. The treated materials may have significant improvements in stability and corrosion resistance. If it is applied to some polymer materials, it can enhance the interaction force between the molecules of the material, make the material more durable, and broaden the use range of the material in different environments.
In short, although 2 - (methylthio) pyridine - 3 - carboxylic acid is an organic compound, its application in the fields of medicine, pesticides, materials science and other fields has injected new vitality into the development of various industries and promoted the continuous progress of related fields.

There is a question today, what is the market price of 2 - (methylthio) pyridine-3 - carboxylic acid. This is a key material in the field of fine chemicals, and the determination of its price is determined by various factors.
The source flow of raw materials has a great impact on their price. If the supply of methyl mercaptan, pyridine and other raw materials is abundant and the price is flat, the cost of 2 - (methylthio) pyridine-3 - carboxylic acid may decrease, and the price will also decrease. On the contrary, if the raw material is scarce and expensive, its cost will rise, and the price will be high.
The skill of production is also an important reason. Advanced and exquisite craftsmanship can increase output and reduce loss, making the product more cost-effective; if the craftsmanship is crude, the output is less and the wear and tear is more, and the price is difficult to be close to the people.
The trend of market supply and demand is related to the fluctuation of prices. If there is strong demand for it in many fields, but the output is not enough, the price will rise; if the market is oversupplied, the manufacturer will sell the goods, or compete at a reduced price.
The difference in regions also leads to price differences. In places where the chemical industry is concentrated and logistics is convenient, the cost of transportation may be low, and the price may be different; in remote places, due to high logistics costs, the price may be high.
Brand and quality also affect its price. < Br >
To sum up, in order to know the exact market price of 2 - (methylthio) pyridine - 3 - carboxylic acid, it is necessary to examine the raw materials, process, supply and demand, region and quality in order to obtain a more accurate number.

2-%28methylsulfanyl%29pyridine-3-carboxylic acid is 2- (methylthio) pyridine-3 -carboxylic acid, which has unique physicochemical properties. Its appearance may be a crystalline powder, white to yellowish in color, which makes light reflect and absorb specific effects due to the arrangement and interaction of atoms in the molecular structure.
When it comes to solubility, it is slightly soluble in water, but it can be soluble in organic solvents such as ethanol and acetone. Because water is a polar solvent, and although the substance contains carboxyl groups, it can form hydrogen bonds with water, but methylthio is a non-polar group, which weakens the overall affinity with water and causes it to be slightly soluble; organic solvents such as ethanol and acetone have moderate polarity, and the force between them is adapted to make them soluble. The melting point of
is about [X] ° C, which is determined by the intermolecular force. When the temperature rises, the energized vibration of the molecule intensifies, and when it reaches the melting point, the kinetic energy of the molecule is sufficient to overcome the interaction force, the lattice disintegrates, and the substance is converted from solid to liquid.
Its stability is good at room temperature and pressure, but it encounters strong oxidants, strong acids and bases, and its structure may change. Because it contains pyridine rings, carboxyl groups and methylthio groups, it is reactive. Pyridine rings are rich in electrons and are easily attacked by electrophilic reagents; carboxyl groups can participate in esterification, acid-base neutralization; sulfur atoms in methylthio groups have lone pairs of electrons, which can be used as nucleophiles or oxidi The physical properties of 2- (methylthio) pyridine-3-carboxylic acids are fundamentally determined by their molecular structure, and they have been used in many fields due to these properties. They are important substances for chemical research and industrial production.