2-Methylpyridine-3-boronic acid HCl salt

2-Methylpyridine-3-borate hydrochloride is a crucial compound in the field of organic synthesis. It has unique chemical properties and has far-reaching effects on many organic reactions.
This compound is solid, has good stability, and exhibits active chemical activity under specific conditions. From the structural analysis, in 2-methylpyridine-3-borate hydrochloride, the pyridine ring endows it with aromaticity and weak alkalinity, while the borate group has electrophilicity and the ability to form hydrogen bonds. The hydrochloride part can enhance its solubility in polar solvents.
In terms of reactivity, boric acid groups can participate in many classical organic reactions, such as the Suzuki-Miyaura coupling reaction. In this reaction, boric acid groups are coupled with organic halides or pseudo-halides in the presence of palladium catalysts and bases to form carbon-carbon bonds, which are widely used in drug synthesis, materials science and other fields to assist in the synthesis of complex organic molecules. Due to the presence of pyridine rings, this compound can provide unique electronic effects and steric barriers in the reaction, which affect the reaction selectivity and facilitate the generation of specific region-selective products.
In terms of solubility, due to the presence of hydrochloride, it has good solubility in water and polar organic solvents such as methanol, ethanol, and dichloromethane, which facilitates its application in solution-phase reactions. The reaction can be carried out efficiently in a homogeneous system, enhancing the contact between the molecules of the reactants, and improving the reaction rate and yield.
In terms of stability, it is relatively stable at room temperature and pressure, but it is more sensitive to humidity. In a humid environment, boric acid groups may undergo side reactions such as hydrolysis, so it needs to be properly stored. It should usually be placed in a dry and cool place, sealed and stored to maintain its chemical stability and ensure that it retains its reactivity during use.

2-Methylpyridine-3-borate hydrochloride has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Gein boric acid groups have unique reactivity and can participate in many key reactions, such as the Suzuki coupling reaction. In this reaction, 2-methylpyridine-3-borate hydrochloride can efficiently form carbon-carbon bonds with halogenated aromatics or halogenated olefins under the action of palladium catalysts and bases, whereby organic compounds with diverse structures can be synthesized, which is of great significance in the field of medicinal chemistry.
In the process of drug development, many drug molecules containing pyridine structures can be prepared by Suzuki coupling reaction using 2-methylpyridine-3-borate hydrochloride as raw material. Pyridine rings are widely found in various active drugs, and their unique electronic structure and spatial configuration endow drugs with specific physiological activities. By modifying the pyridine ring and introducing different substituents, the physicochemical properties and biological activities of the drug can be adjusted.
In addition, in the field of materials science, 2-methylpyridine-3-borate hydrochloride is also used. Functional materials, such as organic semiconductor materials with specific optoelectronic properties, can be prepared through the reaction in which they participate. By rationally designing the reaction path and introducing it into the polymer structure, the material can be endowed with unique electrical and optical properties, which can meet the needs of material properties in different fields.

To prepare 2-methylpyridine-3-borate hydrochloride, the following method is often followed. First take 2-methylpyridine as the starting material, add an appropriate amount of halogenating reagents, such as bromine or chlorine, in an appropriate reactor, under the action of light or initiator, the 3-position halogenation reaction of the pyridine ring occurs to generate 2-methyl-3-halogenated pyridine. This step requires temperature control and reaction time to prevent the formation of polyhalogenated by-products.
The obtained 2-methyl-3-halogenated pyridine is then reacted with metal magnesium to make Grignard reagent. The reaction should be carried out in an inert solvent such as anhydrous ether or tetrahydrofuran because it is stable to Grignard reagents. Grignard reagents have high activity and need to be isolated from water vapor and air during preparation.
Then, the Grignard reagent is reacted with borate esters, such as trimethyl borate or triethyl borate, at low temperature. After the reaction is completed, 2-methylpyridine-3-boronic acid can be obtained by hydrolysis in a dilute acid solution.
Finally, 2-methylpyridine-3-boronic acid is dissolved in an appropriate amount of organic solvent, dried hydrogen chloride gas is introduced, or an appropriate amount of hydrochloric acid solution is added. After reaction, crystallization, filtration, drying and other steps, 2-methylpyridine-3-boronic acid hydrochloride is obtained. Throughout the synthesis process, the reaction conditions of each step need to be carefully controlled, and the purity of raw materials and reagents also has a great impact on the quality of the product, so that high yield and high purity target products can be obtained.

2-Methylpyridine-3-borate hydrochloride is a chemical substance, and the following numbers should be paid attention to when storing.
First, temperature is very important. This substance is quite sensitive to temperature and should be stored in a cool place. Generally speaking, the temperature is 2-8 ° C. If the temperature is too high, or it may cause chemical reactions to change the properties of the substance and reduce its purity and quality; if the temperature is too low, it may also affect its physical or chemical state in some cases.
Second, humidity cannot be ignored. It should be stored in a dry environment to avoid moisture. Because of its certain water absorption, it may cause reactions such as hydrolysis after moisture, which will affect the quality. The humidity in the storage place should be kept within a specific range, for example, the relative humidity should be 40% - 60%, and the dry environment can be maintained by the assistance of desiccants.
Third, pay attention to its isolation from other substances. This chemical may react with other chemicals, so it should be avoided from contact with oxidants, acids, alkalis and other substances when storing. When storing, it should be placed separately from these substances, and the spacing should be kept appropriately to prevent accidental mixing from causing danger.
Fourth, the packaging must be in good condition. When storing, ensure that the packaging is sealed to prevent air, moisture, etc. from entering. If the packaging is damaged, the substance is easily affected by the external environment and accelerates deterioration. At the same time, the packaging material should also be adapted, and materials that can withstand the chemical properties of the substance should be selected to avoid reactions between the packaging and the substance.
In addition, the storage place should be well ventilated. Good ventilation can disperse harmful gases that may be volatile in time and reduce safety risks. And the storage place should be away from fire and heat sources. Because the substance is heated or has potential hazards such as combustion and explosion, the storage environment is safe and secure, and the substance must be properly stored.

The market price range of 2-methylpyridine-3-borate hydrochloride is often changed due to many factors. Looking at the past market, the price of this chemical has been influenced by the cost of raw materials, the complexity of the preparation process, and the market supply and demand situation.
In the past, when the supply of raw materials was abundant and the preparation process was mature, the price was relatively stable. However, if the raw materials were scarce, the production cost would rise, and the price would also rise. Furthermore, the market demand has increased greatly, and the supply is difficult to replenish in time, and the price has also risen.
According to past transaction records, the price fluctuates roughly between a few yuan and tens of yuan per gram. When purchasing in bulk, the unit price may be reduced to a certain extent due to the scale effect. However, the specific price depends on the actual situation of the current market. If the purchaser wants to know the exact price, he should consult with multiple suppliers in detail and compare the quotations at different times in order to clarify the market price range and obtain a reasonable purchase price.