2-(Methylmercapto)pyridine-3-carboxylic acid~2-(Methylthio)pyridine-3-carboxylic acid

2 - (Methylmercapto) pyridine - 3 - carboxylic acid, i.e. 2 - (Methylmercapto) pyridine - 3 - carboxylic acid or 2 - (Methylthio) pyridine - 3 - carboxylic acid, the physical properties of this substance are as follows:
It is usually solid and relatively stable at room temperature and pressure. Looking at its appearance, it is mostly white to off-white crystalline powder. This is due to the characteristics of its molecular structure, which makes the interaction between molecules take on such an appearance.
The melting point is about a specific temperature range, which is critical for the identification and purification of this substance. Due to the influence of the interatomic bonding force and the intermolecular force within the molecule, it undergoes a crystalline transformation at a specific temperature during the heating process, and then changes from solid to liquid.
Furthermore, its solubility is also an important physical property. In organic solvents, such as some alcohols and ether solvents, there is a certain solubility, because the molecules of the substance and the solvent molecules can form interactions such as hydrogen bonds and van der Waals forces, so that it can be dispersed in the solvent. In water, the solubility is relatively limited, which is mainly due to the fact that the hydrophobic part of its molecular structure occupies a certain proportion, which hinders the interaction with water molecules and makes it difficult to form a uniform dispersion system. < Br >
Its density also has a specific value, which reflects the mass of the substance in a unit volume and is closely related to the way molecules are deposited and the relative mass of atoms. The determination of density is of great significance for practical applications, such as material ratio and volume calculation of reaction systems.
In addition, the refractive index of the substance also has a corresponding value. The refractive index reflects the refractive characteristics of light when propagating in the substance, and is related to the distribution of electron clouds and the degree of orderly arrangement of molecules. It can provide a reference for the purity identification and structural analysis of substances. The above physical properties together constitute the physical property description of 2 - (methylthio) pyridine - 3 - carboxylic acid, which is indispensable and important information in chemical research, industrial production and related fields.

2- (methylthio) pyridine-3-carboxylic acid, also known as 2- (methylthio) pyridine-3-carboxylic acid, is a member of the family of organic compounds. It has specific chemical properties and exhibits unique properties due to the presence of pyridine rings, carboxyl groups and methylthio groups in the structure.
From the perspective of physical properties, this compound is usually in solid form, but the specific melting point, boiling point and other characteristics often vary due to differences in purity and experimental conditions. Generally speaking, its melting point or within a certain temperature range, which is affected by intermolecular forces, such as hydrogen bonds, van der Waals forces, etc. The presence of carboxyl groups in the molecule can cause the formation of hydrogen bonds between molecules, which in turn affects the melting point.
Chemically, the carboxyl group is acidic and can be neutralized with bases to form corresponding carboxylic salts. For example, when reacted with sodium hydroxide, the sodium salt of 2- (methylthio) pyridine-3-carboxylate can be obtained with water. This reaction is typical of acid-base neutralization and reflects the active chemical properties of carboxylic groups. At the same time, the pyridine ring also participates in chemical reactions. Because the pyridine ring has certain aromatic and basic properties, electrophilic substitution reactions can occur. However, compared with the benzene ring, the electron cloud density of the pyridine ring is lower, and the electrophilic substitution reaction activity is slightly lower. When the electrophilic reagent attacks the pyridine ring, due to the large electronegativity of the nitrogen atom, the electron cloud is biased towards the nitrogen atom, so that the reactivity at different positions on the pyridine ring is different. Usually, the 3-position and the 5-position are relatively prone to electrophilic substitution.
Furthermore, methylthio also affects the chemical properties of the compound. The sulfur atom in methylthio has a lone pair of electrons, which can participate in the reaction as a nucleophilic reagent, and can also be oxidized to form sulfoxides or sulfone compounds. In case of suitable oxidants, such as hydrogen peroxide, methylthio can be gradually oxidized to derive sulfur-containing compounds in different oxidation states, enriching their chemical transformation pathways.
2- (methylthio) pyridine-3-carboxylic acids have emerged in the fields of organic synthesis and medicinal chemistry due to their unique chemical properties, providing key raw materials and intermediates for the synthesis of many compounds, and occupying an important position in chemical research and industrial production.

2- (methylthio) pyridine-3-carboxylic acid, also known as 2- (methylthio) pyridine-3-carboxylic acid, is widely used. In the field of medicinal chemistry, it is often the key intermediate for the synthesis of many specific drugs. The unique chemical structure of Gainpyridine and carboxyl groups endows the compound with a variety of biological activities, which can act on specific targets in the human body, and then exhibit antibacterial, anti-inflammatory, anti-tumor and other effects. For example, in the process of developing new antibacterial drugs, derivatives prepared from this raw material through multi-step reactions have significant inhibitory effects on specific drug-resistant bacteria.
In the field of materials science, it also has important value. It can be used as a special ligand to complex with metal ions to form metal-organic complexes with unique properties. Such complexes are excellent in fluorescent materials and adsorption materials. Such as the formed fluorescent materials, excellent luminescence properties, can be used in display technology and biological imaging fields; adsorbent materials have high adsorption capacity for specific harmful gases or heavy metal ions, which is of great significance in the field of environmental purification.
In addition, in the field of agricultural chemistry, it can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. With its structural characteristics, pesticides with selective insecticidal and bactericidal activities can be synthesized, which can ensure crop yield while reducing environmental harm and impact on non-target organisms, and achieve sustainable agricultural development.

2 - (methylthio) pyridine-3-carboxylic acid, also known as 2 - (methylthio) pyridine-3-carboxylic acid, has many synthesis methods, such as the following:
First, 2-chloropyridine-3-carboxylic acid is used as the starting material. This raw material reacts fully with sodium methylthiol in a suitable solvent, such as N, N-dimethylformamide (DMF), at an appropriate temperature, such as 60-80 ° C. The chlorine atom of 2-chloropyridine-3-carboxylic acid has high activity, and the sulfur atom in sodium methanethiol has strong nucleophilicity. The nucleophilic substitution reaction occurs between the two, and the chlorine atom is replaced by methylthio group, thereby forming the target product 2- (methylthio) pyridine-3-carboxylic acid. After the reaction, the pure product can be obtained through extraction, washing, distillation and other steps.
Second, take 2-hydroxypyridine-3-carboxylic acid as the starting material. First, it reacts with phosphorus oxychloride to convert the hydroxyl group into a chlorine atom to generate 2-chloropyridine-3-carboxylic acid. Then, according to the above method of using 2-chloropyridine-3-carboxylic acid as raw material, it is reacted with sodium methanethiol to obtain the target product. Although this route has a little more steps, the raw material 2-hydroxypyridine-3-carboxylic acid is easy to obtain.
Third, pyridine-3-carboxylic acid is used as raw material. Under specific conditions, the 2-position of the pyridine ring is introduced into the methylthio group. The activity of the pyridine ring can be used first, and under the action of an appropriate catalyst, such as a specific transition metal catalyst, it can be reacted with a methylthio-containing reagent. This reaction requires precise control of the reaction conditions, and the temperature, reaction time and reagent After careful regulation, methylthio groups were successfully introduced into the 2-position of the pyridine ring to generate 2- (methylthio) pyridine-3-carboxylic acid.
The above methods have their own advantages and disadvantages. In actual synthesis, it is necessary to comprehensively consider the availability of raw materials, cost, difficulty of reaction conditions and other factors, and choose the best one.

2 - (methylthio) pyridine-3 -carboxylic acid. When storing and transporting this product, it is necessary to pay attention to many key points.
First, the storage environment is very important. It should be found in a cool, dry and well-ventilated place. Because the substance may be quite sensitive to humidity and temperature, if the environment is humid, it is easy to cause moisture deterioration and affect the quality. High temperature may also cause chemical reactions, resulting in changes in the properties of the substance. Therefore, it needs to be placed in a suitable temperature. Generally speaking, room temperature (about 15 ° C - 30 ° C) is appropriate, and the humidity should be controlled at a relatively low level, such as 40% - 60%.
Second, the packaging must be tight. It is necessary to choose suitable packaging materials to prevent it from coming into contact with outside air, moisture, etc. It is common to use sealed plastic bags or glass bottles. If it is stored in large quantities in industry, the packaging form of metal barrels wrapped with plastic film is also commonly used. The packaging is well sealed to ensure its stability.
Third, caution is also required during transportation. Violent vibration and collision should be avoided, because it may be fragile or susceptible to external forces. Transportation vehicles need to be kept running smoothly, and they should move slowly when the road conditions are not good. At the same time, pay attention to the temperature and humidity of the transportation environment, and take temperature control or moisture-proof measures if necessary.
Fourth, it needs to be properly isolated from other chemicals. Due to its special chemical properties, or react with certain substances. Therefore, when storing and transporting, it should not be co-located with strong oxidants, strong acids, strong bases, etc., to prevent accidents.
Only by carefully considering the above points during storage and transportation and operating with caution can the quality and safety of 2 - (methylthio) pyridine-3 - carboxylic acid be ensured.