2-Methyl-6-hydroxypyridine

2-Methyl-6-hydroxypyridine is widely used in the field of chemical medicine.
First, it is often a key intermediate in the synthesis of medicine. Because of its unique structure, it can introduce various functional groups through various chemical reactions, and then build a complex drug molecular structure. Taking some antibacterial drugs as an example, with 2-methyl-6-hydroxypyridine as the starting material, through delicate chemical transformation, compounds with specific antibacterial activities can be prepared, which cannot be underestimated in the fight against bacterial infestation and the healing of diseases.
Second, it also has its application in the field of materials science. Due to its structure of nitrogen-containing heterocycles and hydroxyl groups, it can participate in specific polymerization reactions to generate polymer materials with specific properties. Such materials may have excellent thermal stability or good mechanical properties. They can be used as special-purpose materials in high-end fields such as electronics and aviation, such as packaging materials for preparing electronic components, to protect components from external environmental damage and ensure their stable operation.
Third, in the field of organic synthetic chemistry, it is a commonly used synthetic building block. Chemists can skillfully design reaction paths according to their structural characteristics to achieve the synthesis of various organic compounds. The presence of its hydroxyl and methyl groups provides a variety of check points for the reaction, or substitution reactions can occur, or oxidation and reduction changes can be carried out, providing many possibilities for the innovation and expansion of organic synthesis, helping to create new organic compounds, and promoting the development of organic chemistry.

2-Methyl-6-hydroxypyridine is one of the organic compounds. Its physical properties are particularly important and are listed in detail below.
First properties, under normal temperature and pressure, 2-methyl-6-hydroxypyridine is mostly white to pale yellow crystalline powder, which is fine in appearance and uniform in quality. This color feature can be one of the aids in identifying this substance.
The melting point is about 145-148 ° C. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. When the temperature gradually rises to about 145 ° C, 2-methyl-6-hydroxypyridine begins to melt, and completely turns into a liquid at 148 ° C. The value of the melting point is of great significance in experimental operations such as purification and identification of substances, and can be used as a basis for judging purity.
Talking about solubility again, 2-methyl-6-hydroxypyridine is slightly soluble in water. Water is the solvent of all things, but it is only slightly soluble in it, and because of its molecular structure, it interacts weakly with water molecules. However, it has good solubility in organic solvents such as ethanol and ether. The molecular structure of organic solvents such as ethanol and ether is compatible with 2-methyl-6-hydroxypyridine, and the two can be mixed with each other through intermolecular forces, so they can dissolve well. This solubility characteristic can be used in chemical processes such as organic synthesis, separation and purification, which can be used as a reference for selecting suitable solvents.
The boiling point of the compound is within a certain range, about 270-272 ° C. The boiling point is also the temperature at which the surface and interior of the liquid are vaporized at the same time. When the temperature rises to about 270 ° C, the liquid molecule of 2-methyl-6-hydroxypyridine obtains enough energy to break free from the intermolecular binding, and begins to convert into a gaseous state in large quantities. When it reaches 272 ° C, the boiling phenomenon becomes more intense. The nature of the boiling point is crucial in separation methods such as distillation, and the mixture can be separated at different boiling points to obtain pure 2-methyl-6-hydroxypyridine.
In addition, 2-methyl-6-hydroxypyridine still has a certain density, although the exact value varies slightly according to the experimental conditions, it is about 1.12-1.15 g/cm ³. Density is also the mass of a unit volume of a substance, and this value reflects the compactness of the particles inside the substance.
In summary, the physical properties of 2-methyl-6-hydroxypyridine, such as properties, melting point, solubility, boiling point, density, etc., have their own characteristics. They are indispensable reference information in many fields such as chemical industry and scientific research, which can help researchers and practitioners make good use of them for various experimental and production goals.

2-Methyl-6-hydroxypyridine, this is an organic compound with unique chemical properties, which is worth investigating in detail.
Let's talk about its acidity and alkalinity first. Due to the combination of hydroxyl groups and pyridine rings in the molecule, the hydroxyl group can release protons and is acidic; the nitrogen atom of the pyridine ring has a lone pair of electrons, which can accept protons and is alkaline. However, the alkalinity of the pyridine ring is weaker, compared with that of the hydroxyl group, which is more acidic, and the overall acidity is dominant. It can react with bases to generate corresponding salts.
Let's talk about its nucleophilicity and electrophilicity. The electron cloud distribution of the pyridine ring is uneven, and the electron cloud density near the nitrogen atom is high, so that 2-methyl-6-hydroxypyridine has a certain nucleophilicity and can react with electrophilic reagents. Hydroxy oxygen atoms also contain lone pairs of electrons, and the nucleophilicity is not weak, which can participate in reactions such as nucleophilic substitution. At the same time, the carbon atoms on the pyridine ring are affected by the electron-withdrawing effect of nitrogen atoms, and the electron cloud density decreases. When encountering strong nucleophilic reagents, they may exhibit electrophilicity.
On the redox property, hydroxyl groups can be oxidized or form other functional groups such as carbonyl groups. Under specific conditions, they can also participate in the reduction reaction and obtain electrons to change their own structure.
In the field of organic synthesis, 2-methyl-6-hydroxypyridine can be used as a key intermediate due to these characteristics, participating in multiple reactions and constructing complex organic compounds. Its acidity, nucleophilicity, electrophilicity and redox properties are intertwined, endowing this compound with rich chemical reactivity, which is of great value in organic chemistry research and practical production.

The synthesis method of 2-methyl-6-hydroxypyridine has many wonderful methods in the past. One method is to use 2-methyl pyridine as the starting material, and through appropriate oxidation steps, specific oxidants can be used, such as reagents with suitable oxidation ability, to introduce hydroxyl groups at specific positions on the pyridine ring, and then through fine reaction conditions. This process requires careful observation of the subtle relationship between reaction temperature, time and reagent dosage. A slight difference in the pool affects the yield and purity.
Another method uses a pyridine derivative containing a specific substituent as the starting material, and through clever substitution reaction, the methyl and hydroxyl groups are precisely introduced into the expected positions. The key here is to choose the appropriate substitution reagent and catalyst, which complement each other to achieve an efficient and highly selective reaction effect. However, the type, dosage and pH of the reaction environment of the catalyst have a profound impact on the reaction process, and it needs to be tried and tested repeatedly to achieve exquisite control.
It also starts from simple organic raw materials and constructs the structure of 2-methyl-6-hydroxypyridine through multi-step series reaction. Although this path is complicated, each step can be finely crafted, and the synthesis of the target product can be finally achieved by taking advantage of the synergy effect of each step of the reaction. It involves the sequence of various reactions, the stability of intermediates and the conversion efficiency, all of which require careful planning and careful operation to obtain it smoothly. In short, there are many methods for synthesizing 2-methyl-6-hydroxypyridine, each with its own advantages and disadvantages, which need to be weighed according to actual needs.

The price range of 2-methyl-6-hydroxypyridine in the market is difficult to determine. The price often varies due to many reasons, such as the purity of the material, the state of supply and demand, the amount of purchase, and the location of the seller and the buyer.
Looking at the market conditions in the past, the price may fluctuate greatly. If the material is pure and purchased in large quantities, the price may be slightly lower; and if a small amount is needed, or purchased in remote places, the price may increase.
In chemical markets, this product may range from tens to hundreds of yuan per kilogram. If you are on a specialized chemical raw material trading platform, the price may be more reasonable due to competition, but it also varies from time to time.
Also, in recent years, the situation of the chemical industry has changed, the price of raw materials, environmental protection regulations, etc., have caused the production cost and selling price of 2-methyl-6-hydroxypyridine to change. To know the exact price, you need to consult the chemical raw material suppliers in detail, or study the real-time quotation on the relevant trading platform, in order to obtain the more accurate price.