2-Methyl-5-hydroxypyridine

2-% methyl-5-nitropyridine is used in various fields such as medicine, pesticides and materials.
In the field of medicine, it is a key intermediate for the synthesis of a variety of drugs. For example, some antibacterial drugs, with 2-methyl-5-nitropyridine as the starting material, can construct molecular structures with antibacterial activity through a series of chemical reactions, which act on specific targets of bacteria, interfere with their normal physiological metabolism, and achieve antibacterial effect. In the development of anti-tumor drugs, this can be used as the basis for structural modification, or anti-cancer drugs with unique mechanisms of action can be obtained, providing new ways for cancer treatment.
In the field of pesticides, 2-methyl-5-nitropyridine also plays an important role. High-efficiency insecticides can be prepared, which can specifically act on the nervous system or physiological and metabolic pathways of pests, cause paralysis and death of pests, and are relatively friendly to the environment. There are few residues, which can effectively prevent and control pests and ensure crop yield and quality. At the same time, new herbicides may be developed to precisely weed and reduce the impact on crops by inhibiting specific physiological processes of weeds.
In the field of materials, 2-methyl-5-nitropyridine can participate in the synthesis of functional materials. For example, the synthesis of organic materials with special photoelectric properties can be used in organic Light Emitting Diode (OLED), solar cells and other fields. Through rational molecular design and synthesis, the material is endowed with excellent carrier transport performance and luminous efficiency by its structural characteristics, which promotes the development of materials science and improves the performance and application prospects of related devices.
In short, 2-methyl-5-nitropyridine is widely used in many fields due to its unique structure and reactivity, and is of great significance to promoting technological progress and innovation in various fields.

2-% methyl-5-nitropyridine is an organic compound with unique physical properties and important uses in many fields.
This compound is mostly solid at room temperature and has a certain melting point. Due to the molecular structure containing nitro and methyl groups, its melting point and boiling point are specifically affected. The presence of nitro and methyl groups changes the intermolecular force, making the melting point and boiling point different from the simple structure of pyridine compounds.
The appearance of 2-% methyl-5-nitropyridine may be white to light yellow crystalline powder, and the color is related to purity. At high purity, it may be closer to white.
The solubility of this substance in water is low. Due to the hydrophobic groups of pyridine ring, methyl group and nitro group, it has weak interaction with water molecules. However, it has good solubility in some organic solvents such as ethanol and acetone. According to the principle of similar miscibility, its solubility in organic solvents can be used for separation, purification or as a reaction solvent.
2-% methyl-5-nitropyridine has a certain density, and the density is related to the molecular weight and the degree of molecular packing compactness. In chemical production and experimental operations, density data are important for determining the dosage of substances and the ratio of the reaction system.
In addition, it also has a specific odor. Although the odor description is difficult to be accurate, its existence and purity can be preliminarily judged by the odor in actual operation. In conclusion, the physical properties of 2-% methyl-5-nitropyridine are determined by its molecular structure, which lays the foundation for its application in organic synthesis, medicinal chemistry, and other fields.

The 2-% methyl-5-nitropyridine has specific properties and often shows a unique state in various chemical reactions. The methyl group has the property of an electron conductor, which can increase the electron cloud density of the pyridine ring, while the nitro group is a strong electron-absorbing group. The two coexist on the pyridine ring and antagonize each other, which makes the properties of this compound interesting.
In the electrophilic substitution reaction, the electron cloud density of the pyridine ring is greatly reduced due to the strong electron-absorbing effect of the nitro group, especially in the adjacent and para-position of the nitro group, and the electron cloud density decreases even more, so the electrophilic reagent is difficult to be located here. The electron cloud density of the meta-site is relatively high due to the combined action of the methyl power supply and the nitro group, and the electrophilic substitution reaction easily occurs in the meta-site. For example, in the halogenation reaction, halogen atoms are often introduced into the meta-site.
In the nucleophilic substitution reaction, the presence of nitro groups makes the π electron cloud of the pyridine ring biased to nitro groups, so that the carbon atoms of the pyridine ring are partially positively charged and vulnerable to attack by nucleophiles. Especially the adjacent and para-sites of nitro groups have stronger positive electricity, and nucleophiles are easy to react with. For example, when interacting with nucleophiles such as sodium alcohol, corresponding substitution products can be generated.
Its physical properties are also considerable. Due to the presence of polar nitro and methyl groups, the solubility of this compound in polar solvents is different from that of pyridine. And due to the particularity of its molecular structure, the melting boiling point is also affected by the interaction between methyl and nitro.
In addition, 2-methyl-5-nitropyridine is widely used in the field of organic synthesis, and is often a key intermediate for the preparation of complex organic compounds. Due to its unique chemical properties, it can undergo various reactions to construct various functional groups and carbon skeletons, which contribute to the development of organic synthetic chemistry.

2-% methyl-5-nitropyridine is a crucial intermediate in the field of organic synthesis. Its synthesis methods are rich and diverse, and each has its own advantages. The details are as follows:
1. ** Direct nitrification method **: Using methyl-pyridine as the starting material, nitrification reactions are carried out with the help of nitric acid, sulfuric acid and other nitrifying reagents. This method operates straightforwardly, but the regioselectivity is poor, resulting in the generation of a variety of isomers, and the separation and purification process is complicated. For example, under the catalysis of concentrated sulfuric acid, methyl-pyridine reacts with concentrated nitric acid at a specific temperature. Although the target product can be obtained, it is accompanied by impurities such as 2-methyl-3-nitropyridine, which greatly increases the separation difficulty and affects the yield.
2 ** Post-halogenated nucleophilic substitution method **: Schilling methylpyridine halogenation to generate halogenated methylpyridine, and then using nucleophilic reagents, such as nitro negative ions, to replace halogen atoms to achieve the synthesis of the target product. This path has good regional selectivity, but there are many reaction steps and high cost. For example, the reaction of chlorinated methylpyridine with an alcoholic solution of silver nitrate can efficiently obtain 2-methyl-5-nitropyridine, but the early halogenation reaction requires multiple steps, which increases the cost and time cost.
3. ** Palladium-catalyzed cross-coupling method **: With the help of a palladium catalyst, the cross-coupling reaction between halogenated pyridine and nitroaromatics is promoted. This method has mild conditions and high selectivity, but the palladium catalyst is expensive and restricts large-scale production. For example, the reaction of bromomethyl pyridine and nitrophenylboronic acid under the action of palladium catalyst can generate the target product with high selectivity, but the cost of the catalyst is too high, and the economic cost is difficult to reduce.
4. ** Pyridine ring construction method **: Starting from simple raw materials, a pyridine ring is constructed by multi-step reaction, and methyl and nitro are introduced at the same time. This method can flexibly design the reaction route and effectively control the position of the substituent, but the reaction steps are lengthy and the total yield is low. For example, using ethyl acetoacetate, formaldehyde and ammonia as raw materials, 2-methyl-5-nitropyridine is synthesized through multi-step cyclization and nitrification reactions. Although the position of the substituent can be precisely controlled, the process is complicated, and the yield is affected by multi-step reactions.

In today's market, the price of 2-methyl-5-nitropyridine has changed for various reasons. However, looking at the approximate price per kilogram, or in the range of hundreds of gold to thousands of gold.
The reason for this is the price of the raw material. If the raw material is easy to obtain and the price is flat, the production of 2-methyl-5-nitropyridine is also easy, and the price is self-leveling. On the contrary, if the raw material is rare and difficult to obtain, the price will be high, and the cost of its production will increase greatly, and the market price will also rise accordingly.
Furthermore, the difficulty and cost of its production method are also related to its price. If the production method is simple, saves labor and time, and costs less, the price may be low. If the production method is complicated, requires exquisite skills and a lot of material resources, the cost will be high, and the price in the city will be high.
In addition, the supply and demand of the city greatly affects its price. If there are many people in need, but there are not many suppliers, the demand will exceed the supply, and the price will rise. If the supply exceeds the demand, the stock of goods is difficult to sell, and the price will be reduced to promotion.
Moreover, the situation of the world and the laws of politics may also cause the price to change. For example, the increase or decrease of taxes and the regulation of trade can affect its production and sales, and then affect its price.
Therefore, in order to determine the current confirmed price of 2-methyl-5-nitropyridine, the true price can only be obtained by carefully examining the current market conditions, the situation of raw materials, the state of the production method, and various related reasons.