2-Methyl-4-bromopyridine

2-Methyl-4-bromopyridine is also an organic compound. It has a wide range of uses and is often a key intermediate in the field of pharmaceutical synthesis. Due to its unique structure, it can combine with many reagents through various chemical reactions to construct complex drug molecules. For example, in the synthesis of some antibacterial drugs, 2-methyl-4-bromopyridine can introduce specific groups to enhance the effect of the drug on bacteria or improve its pharmacokinetic properties.
It also has important value in the creation of pesticides. It can be used as a starting material to prepare pesticide products with high-efficiency killing effects on pests through a series of transformations. The bromine atoms and methyl groups in its structure can affect the activity, selectivity and stability of pesticides, making the prepared pesticides work more effectively in the field environment and have a controllable impact on the environment.
In addition, in the field of materials science, 2-methyl-4-bromopyridine has also emerged. It can participate in the synthesis of some organic functional materials, giving the materials unique electrical, optical or thermal properties. For example, when synthesizing new optoelectronic materials, its participation in the reaction can adjust the conjugate structure of the material, thereby changing the absorption and emission characteristics of the material to light, providing the possibility for the development of high-performance photoelectric devices.
In summary, 2-methyl-4-bromopyridine, with its unique chemical structure, plays an indispensable role in many fields such as medicine, pesticides, and materials science, promoting the sustainable development and innovation of related industries.

2-Methyl-4-bromopyridine is a member of organic compounds. Its physical properties are unique, let me tell you in detail.
Looking at its properties, under normal temperature and pressure, it is mostly a colorless to light yellow liquid, and this color state is a significant feature of its appearance.
When it comes to the melting point, its value is about -15 ° C. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. At this temperature, the intermolecular forces of 2-methyl-4-bromopyridine change, and the solid lattice structure begins to disintegrate, resulting in a liquid state.
The boiling point is about 195-197 ° C. Boiling point, the temperature at which the saturated vapor pressure of the liquid is equal to the external pressure. At this temperature, a large number of bubbles are generated in the liquid of 2-methyl-4-bromopyridine, which vaporizes violently. This boiling point value indicates that it will boil to a gaseous state at a relatively high temperature.
As for the density, it is about 1.45 g/cm ³. The density reflects the mass of the substance per unit volume. This value reflects the density of 2-methyl-4-bromopyridine compared to common substances such as water, which is heavier than water.
In terms of solubility, 2-methyl-4-bromopyridine is slightly soluble in water. Water is a polar solvent, while the molecular polarity of 2-methyl-4-bromopyridine is limited, so it is difficult to dissolve in water. However, it is soluble in a variety of organic solvents, such as ethanol, ether, chloroform, etc. The molecular structure of organic solvents is similar to that of 2-methyl-4-bromopyridine. According to the principle of "similarity and miscibility", the two can dissolve each other.
In addition, 2-methyl-4-bromopyridine has a certain degree of volatility and can evaporate slowly in air. This volatility is related to factors such as intermolecular forces and temperature. When the temperature increases, the thermal motion of the molecule intensifies, and the volatility increases. Its odor is special and can be perceived by ordinary people. This odor is determined by its molecular structure and is also a basis for identification.
In summary, the physical properties of 2-methyl-4-bromopyridine are of great significance in the fields of organic synthesis and drug development, and researchers need to properly handle and apply them according to their characteristics.

There are several methods for synthesizing 2-methyl-4-bromopyridine.
One is to use pyridine as the starting material. Pyridine is first methylated. Under appropriate conditions, under the catalysis of methylation reagents such as iodomethane, etc., 2-methyl pyridine can be obtained. Then, 2-methyl pyridine is reacted with brominating reagents. Liquid bromine can be selected. Under the catalysis of Lewis acid such as iron tribromide, an electrophilic substitution reaction occurs. Because the 2-position methyl on the pyridine ring is an ortho-para-site group, and the 4-position is affected by the methyl, the electron cloud density is relatively high, which is conducive to the attack of bromine atoms, so as to prepare 2-methyl-4-bromopyridine.
Second, we can start from 2-methyl-4-hydroxypyridine. React 2-methyl-4-hydroxypyridine with a suitable brominating agent, such as phosphorus tribromide or phosphorus pentabromide. In this reaction, the hydroxyl group is replaced by a bromine atom, and through the nucleophilic substitution process, 2-methyl-4-bromopyridine is formed.
Third, 2-methylpyridine nitrogen oxide is used as the raw material. 2-Methylpyridine reacts with peroxides such as m-chloroperoxybenzoic acid to form 2-methylpyridine nitrogen oxide. This nitrogen oxide reacts with a brominating reagent, and the bromine atom can selectively enter the 4-position of the pyridine ring, and then the nitrogen oxide is reduced to remove the oxygen atom on the nitrogen to obtain the target product 2-methyl-4-bromopyridine.
Different synthesis methods have their own advantages and disadvantages, and the appropriate method should be selected according to the actual situation, such as raw material cost, reaction conditions, product purity and other factors.

2-Methyl-4-bromopyridine is an organic compound. When storing and transporting, the following matters should be paid attention to:
First, the storage environment must be dry and cool. This compound is prone to deterioration due to moisture, and the high humidity environment may cause its hydrolysis and other reactions, which will damage the quality. And the temperature is too high to cause its volatilization to intensify, and even cause safety accidents. Therefore, it should be stored in a well-ventilated low-temperature warehouse, away from fire and heat sources.
Second, attention should be paid to sealed storage. Because of its certain volatility, poor sealing is easy to escape into the air, which not only causes material loss, but also may endanger the surrounding environment and human health. It is advisable to use well-sealed packaging containers, such as glass bottles or iron drums lined with plastic bags.
Third, when storing, it should be stored separately from oxidants, acids, alkalis, etc. The chemical properties of 2-methyl-4-bromopyridine are active, and contact with the above substances or cause violent chemical reactions, resulting in serious consequences such as fire and explosion.
Fourth, during transportation, ensure that the container does not leak, collapse, fall, or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. On the way, it should be protected from sun exposure, rain, and high temperature.
Fifth, when handling, it should be handled lightly to avoid vibration, impact and friction. Because it is fragile, rough handling or packaging rupture, material leakage.
Sixth, the relevant operators should receive professional training and strictly abide by the operating procedures. Wear appropriate protective equipment, such as protective glasses, gloves and protective clothing, during operation to prevent injuries caused by contact with materials.

The market price range of 2-methyl-4-bromopyridine is difficult to say exactly. Because the market price is often affected by many factors, it seems that the situation changes and there is no fixed number.
First, the cost of raw materials has a great impact on its price. If the raw materials required for the preparation of 2-methyl-4-bromopyridine fluctuate due to the origin, season, supply and demand situation, the cost of 2-methyl-4-bromopyridine also fluctuates, like ripple diffusion, making it difficult to determine its market price.
Second, the preparation process is also the key. Sophisticated and efficient craftsmanship may reduce production costs and make prices accessible to the people; however, if the craftsmanship is complicated and consumes a lot of manpower, material resources, and financial resources, its price will rise.
Third, the state of market supply and demand is the core factor that controls the price. If the market has strong demand for 2-methyl-4-bromopyridine, but the supply is limited, just like rare things are expensive, prices are bound to rise; on the contrary, if the supply exceeds demand, merchants may reduce prices in order to sell.
Fourth, the prices of 2-methyl-4-bromopyridine produced by different manufacturers will vary due to quality differences. Those with high quality may win higher prices.
According to past market conditions and related information, the price may be between tens of yuan and hundreds of yuan per kilogram. However, this is only an approximate number, and the value is not exact. When actually purchasing or selling, you need to consult major chemical product suppliers, traders, or explore real-time price information on the chemical product trading platform to obtain accurate prices.