2-Methyl-3-iodo-6-bromopyridine

2-Methyl-3-iodine-6-bromopyridine, this substance is crucial in the field of organic synthesis.
First, it is often regarded as an important intermediate in the creation of drug molecules. Geinpyridine ring occupies a core position in many drug structures, and the methyl, iodine and bromine atoms carried by this compound can be modified and transformed through various chemical reactions to meet the specific structure and activity requirements of drug design. For example, iodine atoms and bromine atoms can be coupled, such as Suzuki coupling, Heck coupling, etc., to connect with other organic fragments, expand the molecular structure, and then regulate the interaction between drugs and targets, improve drug activity and selectivity.
Second, in the field of materials science, it also shows unique value. Due to the presence of halogen atoms in its structure, it can participate in the construction of materials with special optoelectronic properties. For example, after appropriate chemical modification, it can become a constituent unit of organic semiconductor materials, which can be used in devices such as organic light emitting diodes (OLEDs) and organic field effect transistors (OFETs) to endow materials with specific electrical and optical properties, such as adjusting the color of light emission and improving carrier mobility.
Third, in the field of pesticide synthesis, it is also an important raw material. The biological activity of pyridine compounds can be modified by methyl and halogen atoms, which may create efficient, low-toxic and environmentally friendly pesticide varieties. By adjusting its chemical structure, it can optimize the mode and effect of action against specific pests or pathogens, providing a powerful tool for agricultural pest control.
In conclusion, 2-methyl-3-iodine-6-bromopyridine plays an indispensable role in many fields such as organic synthesis, drug development, materials science, and pesticide creation. Its unique structure provides rich possibilities and broad application prospects for various chemical reactions and the construction of functional materials.

To prepare 2-methyl-3-iodine-6-bromopyridine, there are several common synthesis methods as follows.
First, 2-methylpyridine is used as the starting material. First, 2-methylpyridine is brominated. Suitable brominating reagents, such as liquid bromine and suitable catalysts, can be used to bromide at specific positions on the pyridine ring at appropriate temperatures and reaction conditions to obtain 6-bromo-2-methylpyridine. Then, it is iodized, and a suitable iodizing reagent is selected, such as iodine in combination with a suitable oxidizing agent. In a specific reaction system, 3 positions of 6-bromo-2-methylpyridine are introduced into the iodine atom to obtain the target product 2-methyl-3-iodine-6-bromo-pyridine. In this route, the bromination step needs to pay attention to the reaction selectivity and ensure that the bromine atom is mainly introduced into the 6 positions; the iodization step should control the reaction conditions to avoid overreaction and side reactions.
Second, the strategy of gradually constructing substituents can also be started from the pyridine derivatives. For example, a pyridine derivative containing an appropriate substituent is prepared first, and the substituent of the derivative is converted into methyl, bromine and iodine atoms through a series of reactions. This process may involve multiple organic reactions, such as nucleophilic substitution, oxidation and reduction. The reaction sequence needs to be carefully designed, and the relevant functional groups need to be reasonably protected and removed to ensure the smooth progress of each step of the reaction, and finally 2-methyl-3-iodine-6-bromo pyridine is obtained.
Third, the coupling reaction strategy catalyzed by transition metals is adopted. Pyridine derivatives containing different active groups can be prepared first. Using transition metal catalysts, such as palladium catalysts, in the presence of suitable ligands and bases, methyl, bromine and iodine atoms can be introduced through the coupling reaction of halogenated aromatics and organometallic reagents, respectively. This method requires screening suitable catalysts, ligands and reaction conditions to improve reaction efficiency and selectivity, reduce side reactions, and accurately synthesize 2-methyl-3-iodine-6-bromopyridine.

2-Methyl-3-iodine-6-bromopyridine is one of the organic compounds. Its physical properties are quite important and are the basis for many chemical applications.
First of all, its appearance, at room temperature, this compound is mostly solid, its specific appearance may vary due to factors such as purity, but it is usually a crystalline solid, with a dense state, and it may have a certain luster.
As for the melting point, due to the interaction between atoms in the molecular structure, the melting point is in a specific temperature range. The interaction between bromine, iodine and other halogen atoms in the molecule and the pyridine ring and methyl makes the intermolecular force unique. Therefore, the melting point can be accurately determined by experiments. This temperature is of great significance for the thermal stability study of the compound and the setting of related chemical reaction conditions.
Boiling point is also a key physical property. When enough heat is applied, the molecules can break free from each other's forces and vaporize, and the boiling point is the temperature at this time. The boiling point of 2-methyl-3-iodine-6-bromopyridine is affected by factors such as intermolecular van der Waals force and hydrogen bonds. Among them, the electronegativity of the halogen atom is relatively large, which makes the molecule have a certain polarity, enhances the intermolecular force, and then affects the boiling point.
In terms of solubility, this compound exhibits different solubility in common organic solvents. In polar organic solvents, such as ethanol, acetone, etc., due to the polarity of the molecule, hydrogen bonds or dipole-dipole interactions can be formed with the solvent molecules, so there is a certain solubility; in non-polar solvents, such as n-hexane, the solubility is relatively small due to the large difference in intermolecular forces.
Density is also one of its physical properties. Its density depends on the relationship between the mass of the molecule and the occupied space. In the 2-methyl-3-iodine-6-bromopyridine molecule, the relative atomic weight of bromine and iodine atoms is relatively large, which increases the molecular weight. At a specific temperature and pressure, the density also presents a specific value. This value is considered in chemical production, material separation and other processes.

2-Methyl-3-iodine-6-bromopyridine is also an organic compound. Its chemical properties are well-researched.
First of all, its halogen atom-related properties. The compound contains bromine and iodine two halogen atoms, which are quite active. In the nucleophilic substitution reaction, both bromine and iodine atoms can be attacked by nucleophiles, and the halogen atoms can leave and new groups can be accessed. In case of alcohol nucleophiles, under appropriate alkali and reaction conditions, corresponding ether compounds can be formed; if they meet with amine nucleophiles, nucleophilic substitution can also occur, resulting in nitrogen-containing derivatives. Because the halogen atom is connected to the pyridine ring, it is affected by the ring electron effect, and its carbon-halogen bond has a certain polarity, which is conducive to the attack of nucleophiles.
Furthermore, the properties of the pyridine ring are also key. The pyridine ring is aromatic, and the electron cloud distribution on the ring is uneven. The nitrogen atom has strong electronegativity, which makes the electron cloud on the ring biased, so the electron cloud density of the α and γ positions of the pyridine ring is relatively low, and the β position is relatively high. This electron cloud distribution characteristic affects the reaction activity and check point selectivity of the compound. For example, during the electrophilic substitution reaction, the electrophilic reagents are more likely to attack the β position. However, due to the presence of methyl, bromine, iodine and other substituents in this compound, the distribution of electron cloud changes, which further affects the reactivity and selectivity.
methyl also has its influence. Methyl is a power supply group, which can slightly increase the electron cloud density of the pyridine ring through induction and superconjugation effects, especially on the adjacent and para-sites. This makes the adjacent and para-sites relatively more prone to electrophilic substitution reactions, and also has a subtle effect on the activity of halogen atoms. It changes the stability of carbon cations connected to halogen atoms and indirectly affects the activity of nucleophilic substitution reactions.
In summary, the chemical properties of 2-methyl-3-iodine-6-bromopyridine are formed by the interaction of pyridine ring, halogen atom and methyl group, and have diverse reactivity and potential application value in the field of organic synthesis.

The price range of 2-methyl-3-iodine-6-bromopyridine in the market is difficult to determine. The price of this compound often changes due to multiple reasons.
First, the difficulty of preparation is the main reason for the price. If its preparation requires propagation methods and high materials, the price must be high. The synthesis of 2-methyl-3-iodine-6-bromopyridine involves a multi-step reaction, and the introduction of iodine and bromine, or special methods and reagents, which can increase the difficulty of preparation and lead to high prices.
Second, the supply situation is also the key to the price. If the industry is seeking prosperity for this product, but the supply is limited, the price will rise; on the contrary, if the light supply is more, the price may drop.
Third, the purity of the product has an impact on the price. High-purity 2-methyl-3-iodine-6-bromopyridine is not easy to prepare, and the price must be higher than those with slightly lower purity.
Looking at the past market conditions, the price of such fine chemicals may range from tens of yuan to hundreds of yuan per gram. If purchased in quantity, the price per gram may drop due to the benefits of wholesale. However, the exact price still needs to be consulted with the chemical supplier. The price varies from time to time and the market. To know the exact price, ask the merchants in detail to obtain a real-time quotation.