2-methoxypyridine-4-carbaldehyde

2-Methoxypyridine-4-formaldehyde, an organic compound, has unique physical properties and is of great significance in chemical research and industrial production.
Looking at its properties, under room temperature and pressure, 2-methoxypyridine-4-formaldehyde is mostly light yellow to yellow liquid, with a clear appearance and a certain fluidity. This color state is convenient for researchers to initially identify its state and purity through the naked eye during the experiment.
When it comes to odor, it emits a special pungent odor. This odor is significant, and researchers need to be cautious when operating, because it may cause irritation to the human respiratory tract, eyes and other parts. Therefore, during the experimental operation, it is necessary to use a well-ventilated environment or protective equipment to ensure safety. The melting point and boiling point of 2-methoxypyridine-4-formaldehyde are also key physical properties. Its melting point is about -10 ° C, and its boiling point is between 245-247 ° C. The low melting point causes it to be liquid at room temperature; the higher boiling point indicates that a higher temperature is required to vaporize it. This property plays a significant role in the separation and purification of compounds. For example, when separating mixtures by distillation, effective separation can be achieved according to their boiling point differences.
In terms of solubility, 2-methoxypyridine-4-formaldehyde is soluble in a variety of organic solvents, such as ethanol, ether, dichloromethane, etc. This solubility facilitates organic synthesis reactions because it can fully contact and react with many organic reagents in the same solvent system, promoting the smooth progress of chemical reactions. However, its solubility in water is limited. This property makes it necessary to consider its interaction with the aqueous phase in the reaction or separation process, and choose an appropriate method to achieve the target reaction or separation operation.
In addition, the density of 2-methoxypyridine-4-formaldehyde is about 1.18 g/cm ³, which is slightly heavier than water. When it comes to operations such as liquid-liquid separation, it is necessary to consider their density differences in order to accurately determine the distribution of each phase and achieve efficient separation.

2-Methoxypyridine-4-formaldehyde is a very important chemical substance in organic synthesis. It has many unique chemical properties, and this is a detailed discussion for you.
First, the properties of its aldehyde groups. The aldehyde group is very active and can participate in many key chemical reactions. For example, oxidation reactions, under the action of suitable oxidants, the aldehyde group can be oxidized to a carboxyl group, resulting in 2-methoxypyridine-4-carboxylic acid. This acid may have specific uses in the fields of drug synthesis and materials science. < Br >
In addition, it is a reduction reaction. The aldehyde group can be converted into a hydroxyl group by the action of a reducing agent to obtain 2-methoxy-4-hydroxymethylpyridine. This product may act as an important intermediate in the preparation of some functional compounds.
The aldehyde group can also participate in the nucleophilic addition reaction. If it is catalyzed by an acid with an alcohol, it can undergo acetalization reaction to form an acetal structure. This structure is of great significance in the design of organic synthesis steps to protect the aldehyde group from other reagents.
And the pyridine ring also gives the compound special properties. The pyridine ring is alkaline to a certain extent, because it has lone pairs of electrons on the nitrogen atom and can accept protons. This alkalinity enables 2-methoxypyridine-4-formaldehyde to react with acids to form corresponding salts.
The electron cloud distribution characteristics of the pyridine ring determine that it can participate in the electrophilic substitution reaction. However, due to the electron-withdrawing effect of nitrogen atoms, the reactivity is slightly different from that of the benzene ring. Usually, the electrophilic substitution reaction occurs mostly in the position where the electron cloud density of the pyridine ring is relatively high.
In addition, the connection of methoxy groups to the pyridine ring also affects the properties of the compound. Methoxy groups act as the donating groups, which can increase the electron cloud density at specific positions of the pyridine ring, thereby affecting the regioselectivity of the electrophilic substitution reaction. In conclusion, 2-methoxypyridine-4-formaldehyde has a wide range of chemical properties due to the presence of aldehyde groups, pyridine rings and methoxy groups, and has broad application prospects in many fields such as organic synthesis and medicinal chemistry.

There are several common methods for the synthesis of 2-methoxypyridine-4-formaldehyde as follows.
One is to use 2-methoxypyridine as the starting material. First, it reacts with suitable reagents and introduces an aldehyde group at the 4th position of the pyridine ring. The Vilsmeier-Haack reaction can be used to co-heat 2-methoxypyridine with N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl). In the reaction, POCl reagents react with DMF to form an active Vilsmeier reagent. This reagent attacks the fourth position of 2-methoxypyridine, and after hydrolysis, 2-methoxypyridine-4-formaldehyde is obtained. Pay attention to the control of reaction temperature and time during the reaction. If the temperature is too high or the time is too long, side reactions may occur, such as further chlorination of pyridine rings.
The second can be started from 4-methyl-2-methoxypyridine. The methyl group is oxidized to an aldehyde group first. The commonly used oxidizing agents are manganese dioxide (MnO _ 2), chromic acid and its salts. Taking manganese dioxide as an example, in a suitable solvent, such as glacial acetic acid or dichloromethane, the methyl group of 4-methyl-2-methoxypyridine can be selectively oxidized to an aldehyde group to obtain the target product 2-methoxypyridine-4-formaldehyde. In this process, the choice of solvent is quite critical, and different solvents affect the reaction rate and selectivity.
Furthermore, metal-organic reagents can be used to synthesize. For example, 2-methoxy-4-halopyridine is reacted with magnesium metal to make Grignard reagent, then reacted with formaldehyde or paraformaldehyde, and then hydrolyzed to obtain 2-methoxy-4-formaldehyde. When preparing Grignard reagent, it is necessary to ensure that the reaction system is anhydrous and oxygen-free, otherwise Grignard reagent is easy to decompose and affect the reaction yield.

2-Methoxypyridine-4-formaldehyde, which is useful in many fields.
In the field of medicinal chemistry, it is often a key intermediate. The special structure of geinpyridine and methoxy and aldehyde groups makes it possible to participate in a variety of chemical reactions and help synthesize various biologically active compounds. For example, the synthesis of specific targeted drugs, whose structures can be modified to fit specific receptors or enzymes, in order to achieve the purpose of precision treatment, may emerge in the development of anti-tumor and antiviral drugs.
In the field of materials science, it also has potential. With its unique chemical structure, it may be used to prepare functional materials. After appropriate reaction, it can be introduced into polymer materials, imparting materials such as fluorescent properties, and applied to optical sensor materials, which can respond sensitively to specific substances or environmental changes to achieve substance detection or environmental monitoring.
In the field of fragrances, 2-methoxypyridine-4-formaldehyde can also be used. The aldehyde group is combined with the pyridine ring, which may produce a unique odor. After formulation, it can become a new type of fragrance ingredient, adding new flavors to fragrance formulations, and is used in food, cosmetics and other industries to enhance the olfactory experience of products.
In the field of organic synthetic chemistry, it is an important cornerstone. It can construct complex organic molecular structures through many classical organic reactions, such as condensation reactions involving aldehyde groups and addition reactions with nucleophiles, which help chemists explore new reaction paths and synthesis strategies, and promote the development of organic synthetic chemistry.

What you are inquiring about is the market price of 2-methoxypyridine-4-formaldehyde. However, the market price of this chemical cannot be covered in one word.
The price of the cover often varies due to a variety of factors. First, the price of raw materials is also. If the price of the various raw materials required for the preparation of 2-methoxypyridine-4-formaldehyde rises or falls, the price of the finished product will also fluctuate. For example, if the specific pyridine raw materials used for the preparation of this aldehyde are in short supply, the price will be high, and the price of this aldehyde will also rise.
Second, the supply and demand trend has a great impact. If the market demand for this aldehyde is strong, but the output is limited, the price will go up; on the contrary, if the supply exceeds the demand, the merchant will reduce the price in order to sell its goods.
Third, the simplicity of the production process is closely related to the cost. If the process is complicated, high-end equipment and fine operation are required, and the energy consumption is also large, the cost will be high, and the price will also be high; if there is a simple and efficient new process, the cost will drop, and the price will also drop.
Fourth, the state of market competition cannot be underestimated. Many manufacturers compete for production and sales, competing for share, or lowering prices; if there are few manufacturers, the potential for monopoly will be established, and the price may be controllable at a high level.
And depending on the region, the price is also different. Prosperous commercial port, convenient transportation, low logistics cost, price or relatively easy; remote places, inconvenient transportation, cost increase, price or slightly higher.
Therefore, in order to know the exact market price of 2-methoxypyridine-4-formaldehyde, when you carefully observe the raw material market, supply and demand situation, process cost, competition landscape and regional differences and many other factors, or consult the chemical products trading platform, industry merchants, manufacturers, can get more accurate price.