2 Methoxypyridine 4 Boronicacid
pyridine pyrrole pyrazine piperidine piperazine

2-Methoxypyridine-4-boronicacid

    Specifications

    HS Code

    552129

    Chemical Formula C6H8BNO3
    Molecular Weight 152.94
    Appearance White to off - white solid
    Purity Typically high - purity (e.g., 95%+ in commercial products)
    Solubility In Water Moderate solubility
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane
    Melting Point 140 - 145 °C (approximate)
    Boiling Point Decomposes before boiling under normal conditions
    Stability Stable under normal storage conditions, may react with strong oxidizing agents

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    Frequently Asked Questions

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    What are the chemical properties of 2-methoxypyridine-4-boronic acid?
    2-% methoxypyridine-4-boronic acid, this physical property belongs to the class of organoboron compounds. Its shape is usually white to light yellow crystalline powder, which is widely used in the field of scientific research and chemical synthesis.
    When it comes to chemical properties, the first thing to bear the brunt is the characteristics of its boron atoms. Boron atoms are electron-deficient, which makes them an electrophilic center in this compound and easy to react with electron-rich reagents. This property makes 2-% methoxypyridine-4-boronic acid a key intermediate in many organic reactions.
    In coupling reactions, this compound is particularly prominent. Such as Suzuki coupling reaction, 2% methoxypyridine-4-boronic acid can react smoothly with halogenated aromatics or olefins in the presence of alkali and palladium catalysts to form carbon-carbon bonds. The reaction mechanism is that the palladium catalyst is first oxidized with the halogenate, followed by metal transfer with boric acid, and finally eliminated by reduction to obtain the coupling product. With this reaction, a variety of organic molecules with special structures and functions can be easily synthesized, which is of great significance in the fields of drug development and materials science.
    Furthermore, its pyridine ring also gives the compound unique chemical properties. The pyridine ring has a certain alkalinity and can form salts with acids, and the electron cloud on the ring is unevenly distributed, and electrophilic substitution reactions can occur at specific positions. At the same time, the presence of methoxy groups affects the electron cloud density of the pyridine ring due to the electron donor effect, further regulating the reactivity and selectivity.
    In addition, the stability of 2-% methoxypyridine-4-boronic acid is acceptable under moderate conditions, but when encountering strong oxidizing agents, strong acids or strong bases, the structure may be damaged. Therefore, it is necessary to pay attention to environmental factors when storing and using, and it is usually recommended to keep it in a dry and cool place to avoid contact with the above substances. In summary, 2-% methoxypyridine-4-boronic acid occupies an important position in the field of organic synthesis chemistry due to its unique chemical properties, providing an effective way for the creation of novel organic compounds.
    What are the common synthesis methods of 2-methoxypyridine-4-boronic acid?
    The common synthesis methods of 2-% methoxypyridine-4-carboxylic acid cover the following kinds:
    First, pyridine is used as the starting material and obtained by multi-step reaction. First, the pyridine is reacted with a suitable halogenated reagent under specific conditions to introduce a halogen atom, which can be used as an activity check point in subsequent reactions. Subsequently, by means of a nucleophilic substitution reaction, the halogen atom is replaced by a methoxy negative ion to generate a methoxy-containing pyridine derivative. After an appropriate oxidation step, the group at a specific position on the pyridine ring is oxidized to a carboxyl group, so that the target product 2-% methoxypyridine-4-carboxylic acid can be obtained. Although there are many steps in this method, the raw material pyridine has a wide range of sources, and the reaction conditions are relatively easy to control, so it is quite commonly used in the field of organic synthesis.
    Second, the coupling reaction catalyzed by transition metals can be used. Compounds containing pyridine rings with suitable leaving groups can be selected, and under the action of methoxylation reagents on transition metal catalysts such as palladium catalysts, a coupling reaction occurs to form a connection between methoxy groups and pyridine rings. Then, through a specific carboxylation reaction, a carboxyl group is introduced at a specific position of the pyridine ring. With the help of the efficient catalytic performance of transition metal catalysts, this method can achieve precise chemical bond construction, and the reaction selectivity is high, which can effectively reduce the occurrence of side reactions, and shows unique advantages in the synthesis of complex pyridine derivatives.
    Third, the biosynthesis method is adopted. Using a specific microorganism or enzyme system, using a suitable substrate as raw material, through the enzymatic reaction in vivo, the synthesis of 2-% methoxypyridine-4-carboxylic acid is achieved. This method has the advantages of green environmental protection, mild reaction conditions, etc., without the use of a large number of toxic and harmful chemical reagents and harsh reaction conditions. However, biosynthesis also faces many challenges, such as the stability of biological systems, substrate specificity, etc. It is necessary to fine-tune and optimize biological systems in order to achieve efficient synthesis.
    In which fields is 2-methoxypyridine-4-boronic acid used?
    2-% methoxypyridine-4-boronic acid is used in various fields. It is a key synthetic building block in the field of medicinal chemistry. Due to its unique structure and reactivity, it can react with a variety of compounds to form complex and biologically active molecules. Doctors often use it to create new drugs to treat various diseases. For example, based on it, they can construct targeted anti-cancer drugs that precisely act on cancer cells, inhibit their growth and proliferation, reduce patient pain, and increase the hope of cure.
    In the field of materials science, 2-% methoxypyridine-4-boronic acid also shows important value. Can be used in the preparation of functional materials, such as luminescent materials. After rational design and synthesis, it can be integrated into the material structure and give the material unique optical properties. The luminescent materials can be used in display technology to make the color of the display screen more vivid and clear, and improve the visual experience; or used in biological imaging to help researchers gain a clearer insight into the microscopic structure and physiological process of the organism, and explore the mysteries of life.
    In the field of organic synthetic chemistry, it is an excellent intermediate. Chemists can use it to participate in many organic reactions such as coupling reactions to realize the construction of carbon-carbon bonds and carbon-heteroatomic bonds, and expand the structural diversity of organic molecules. This plays a significant role in the creation of new compounds and the development of new synthesis methods, and contributes to the development of organic synthetic chemistry. For example, in the coupling reaction of Suzuki-Miyaura, 2% methoxypyridine-4-boronic acid is often used as an important substrate to react with halogenated aromatics, etc., to efficiently synthesize various biaryl compounds, which are widely used in the preparation of fine chemical products.
    What is the market price of 2-methoxypyridine-4-boronic acid?
    Today I have a question, what is the market price of 2-aminoethoxyethanol-4-sulfonic acid? Let me tell you in detail for you.
    This 2-aminoethoxyethanol-4-sulfonic acid is widely used in the chemical industry. Its price often varies due to changes in quality, origin, and market supply and demand.
    If it is of high quality, it mostly comes from large factories with exquisite craftsmanship. They have strict production control, high product purity, few impurities, and natural prices are high. The origin also has an impact. If it is located in a place with abundant resources and convenient transportation, the cost will be slightly reduced, and the price may be more affordable.
    On the supply and demand side of the market, if there are many people who want it, and there are few producers, the price will rise; on the contrary, if the supply exceeds the demand, the price will tend to fall.
    In the current market, the price of this product is about [X] yuan to [X] yuan per kilogram. However, this is only a rough number, and the actual price may vary from time to time. When merchants trade, they often negotiate the price based on the size of the batch, and there may be discounts for those with large quantities.
    is to know the exact price, and it is necessary to study the market carefully and negotiate with various suppliers before they can obtain it.
    What are the storage conditions for 2-methoxypyridine-4-boronic acid?
    2-% methoxypyridine-4-boronic acid should be sealed and stored in a dry, cool and well-ventilated place. This substance is sensitive to humidity and easily reacts with water vapor in the air, causing changes in its structure and properties, which in turn affect its quality and use efficiency. Therefore, it is essential to maintain a dry environment to prevent it from deteriorating due to moisture.
    A cool environment is also indispensable. Excessive temperature may trigger the decomposition of the substance or accelerate its potential reaction with other substances. High temperature environments may destabilize the molecular structure, causing its chemical activity to change, making it impossible to meet the corresponding use requirements.
    Well-ventilated can disperse harmful gases that may be generated by the volatilization of the substance itself or the reaction with the surrounding environment in time, ensure the air quality of the storage space, and also help to maintain the relative stability of the storage environment temperature.
    Sealed storage is to effectively isolate the outside air, water vapor and other impurities that may react with it. By sealing, the substance can be avoided from direct contact with the outside environment, reduce the risk of chemical reactions, and maintain the stability of its chemical properties to the greatest extent. When it is needed, 2% methoxypyridine-4-boronic acid can exhibit its due performance and quality. In this way, the quality and stability of this chemical substance during storage can be ensured for subsequent use.