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What is the chemical structure of 2-methoxyethyl (2E) -3-phenylpropyl-2-ene-1-yl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate?
An organic compound having the structure of 2-methoxyethyl (2E) -3-phenylpropane-2-ene-1-yl-2,6-dimethyl-4- (3-furanylphenyl) -1,4-dihydropyridine-3,5-dicarboxylate. The structure consists of a pyridine ring with a dihydro configuration at 1,4 positions and a dicarboxylic acid ester group at 3,5 positions. 2-Methoxyethyl (2E) -3-phenylpropyl-2-enyl-1-yl, 6-dimethyl, and 4-furanylphenyl.
3,5-dicarboxylic acid ester group of the pyridine ring makes the compound have certain hydrophilicity and reactivity. It can be used as a check point in the field of organic synthesis and medicinal chemistry, participating in ester formation, amidation and other reactions. The 2-methoxyethyl (2E) -3-phenylpropane-2-ene-1-yl of the 2-position side chain, the carbon-carbon double bond and the benzene ring endow the compound with a certain conjugate structure and hydrophobicity, which affect its physicochemical properties and biological activities. The carbon-carbon double bond can undergo reactions such as addition and polymerization. The introduction of 6-position dimethyl changes the electron cloud distribution and steric resistance of the pyridine ring, affecting the stability of the compound and the interaction between molecules. The 4-position 3-furanylphenyl group, the presence of furan ring and phenyl ring, further expands the conjugate system, enhances the hydrophobicity and electron delocalization ability of the compound, or affects its spectral properties and interaction with biological targets.
This compound has a unique structure, and a variety of functional groups and substituents coexist, providing possibilities for its application in drug development, materials science and other fields. Different substituents interact or endow it with special physical, chemical and biological activities, which can be used as lead compounds for activity screening and structure optimization.
What are the physical properties of 2-methoxyethyl (2E) -3-phenylpropyl-2-ene-1-yl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate?
2-Methoxyethyl (2E) -3-phenylpropyl-2-ene-1-yl-2,6-dimethyl-4- (3-furanylphenyl) -1,4-dihydropyridine-3,5-dicarboxylic acid ester, which has many physical properties. Its appearance is often white to light yellow crystalline powder, which is due to the interaction of various groups in the molecular structure, so that the molecules are arranged in an orderly manner, and it appears in this shape on a macro level.
From the perspective of solubility, it has a certain solubility in organic solvents such as ethanol and acetone. This is because the molecule of the substance contains a variety of organic groups, which can form interactions such as van der Waals forces and hydrogen bonds with organic solvent molecules, thus promoting its dissolution. However, the solubility in water is very small, because the polarity of water molecules is strong, and the overall polarity of this compound is relatively weak, and the interaction with water is difficult to overcome the strong hydrogen bond between water molecules, so it is difficult to dissolve in water.
Its melting point is in a specific range, which is determined by the intermolecular force. The aromatic ring, ester group and other structures existing in the molecule make the molecule have strong π-π stacking, van der Waals forces, and the interaction between ester groups. These effects require a certain amount of energy to overcome, resulting in the material having a corresponding melting point.
In addition, the substance has good stability in the solid state, because its molecular structure is relatively stable, and the atoms are closely connected by chemical bonds. However, under extreme conditions such as high temperature, strong acid, and strong base, some chemical bonds in the molecular structure may be broken or rearranged. For example, ester groups may undergo hydrolysis reactions in strong acid or strong base environments, destroying the original structure of the molecule, thereby affecting its physical and chemical properties.
What are the synthesis methods of 2-methoxyethyl (2E) -3-phenylpropyl-2-ene-1-yl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate?
To prepare 2-methoxyethyl (2E) - 3-phenylpropyl-2-ene-1-yl-2,6-dimethyl-4 - (3-furanylphenyl) - 1,4-dihydropyridine-3,5-dicarboxylic acid esters, the following ancient methods can be used.
First, use the corresponding alcohol and halogenated hydrocarbons as starting materials. First take an appropriate amount of alcohol, add a specific base as a catalyst in a suitable reaction vessel, stir well, and make the system temperature reach a certain stable value. Subsequently, the halogenated hydrocarbons are slowly added dropwise, and the speed of the dropwise addition process needs to be strictly controlled to avoid the reaction being too violent. After the dropwise addition is completed, the reaction is continuously stirred for a period of time until the reaction is sufficient. This step aims to form a key carbon-oxygen bond through a nucleophilic substitution reaction, and build the basic skeleton of the target molecule.
Second, the condensation reaction is carried out using aldehyde and ketone as raw materials. The aldehyde and ketone are placed in a reaction kettle in a specific ratio, and a little acid or base is added as a catalyst. Under certain temperature and pressure conditions, the two condensation occurs. During this reaction, the active check points of the carbonyl compound interact to form a carbon-carbon double bond, which lays the foundation for the double bond structure of the target product. During the reaction, it is necessary to closely monitor the reaction process and adjust the reaction conditions in a timely manner to ensure that the reaction proceeds in the desired direction.
Third, the synthesis method of pyridine derivatives is used. Select the appropriate parent pyridine, and gradually introduce the required substituents through a series of substitution reactions. First introduce methyl at a specific position of the pyridine ring, and methylating reagents can be used to complete the substitution under suitable reaction conditions. Then, introduce phenyl, furyl and other groups in turn. Each step of the substitution reaction requires careful selection of reaction reagents and conditions to ensure the accuracy of the substitution position and the high efficiency of the reaction. This process is like building a delicate pavilion, building layer by layer, and gradually approaching the complex structure of the target product.
By the above methods, 2-methoxyethyl (2E) - 3-phenylpropane-2-ene-1-yl 2,6-dimethyl-4 - (3-furanylphenyl) - 1,4-dihydropyridine-3,5-dicarboxylic acid esters can be prepared. However, the reaction conditions and reagent dosage of each step need to be carefully controlled during the reaction process to obtain the desired result.
2-Methoxyethyl (2E) -3-phenylpropane-2-ene-1-yl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylic acid esters are used in what fields?
Wuguanzi said "2-methoxyethyl (2E) -3-phenylpropyl-2-ene-1-yl + 2,6-dimethyl-4 - (3-pyridylphenyl) -1,4-dihydropyridine-3,5-dicarboxylate", which is a complex compound of organic chemistry. It is widely used in the field of medicine and can be used as a key intermediate for drug development. Due to its specific structure or unique biological activity, it can interact with biological macromolecules in vivo, such as binding to specific receptors, regulating physiological processes, and achieving the purpose of treating diseases.
In the field of materials science, such compounds may participate in the synthesis of new materials. By virtue of their structural properties, they endow materials with unique physical and chemical properties, such as improving the optical properties and thermal stability of materials. For example, in optoelectronic device materials, it may optimize the material's light absorption and emission properties and improve device efficiency.
In the field of organic synthetic chemistry, it is also an important synthetic building block. Chemists can use various organic reactions to modify and derive their structures to synthesize more organic compounds with diverse structures and unique functions, expand the library of organic compounds, and provide rich materials for subsequent research and applications. In short, this compound has potential application value in many fields and is of great significance to promote the development of related fields.
How safe is 2-methoxyethyl (2E) -3-phenylpropyl-2-ene-1-yl 2,6-dimethyl-4- (3-nitrophenyl) -1,4-dihydropyridine-3,5-dicarboxylate?
A strange substance, called 2-methoxyethyl (2E) -3-phenylpropyl-2-ene-1-yl-2,6-dimethyl-4- (3-carbonylphenyl) -1,4-dihydropyridine-3,5-dicarboxylate. The safety of this strange substance is related to many aspects.
From the perspective of its structure, it contains various functional groups. The methoxyethyl moiety may have specific activities in certain reactions, but it interacts with surrounding groups in the overall structure, or affects the stability and reactivity. Phenylpropyl-alkenyl structure, or because of the conjugate system and important contributions to the properties of compounds, but may also be due to the presence of double bonds, causing it to be unstable under oxidation and other conditions, leading to safety concerns.
Dimethyl and dihydropyridine and dicarboxylate moiety, also have an impact. Dimethyl can change the molecular spatial configuration and electron cloud distribution; the existence of dihydropyridine ring, so that the molecule has unique electronic properties, or participate in oxidation and reduction reactions; dicarboxylate moiety, under conditions such as hydrolysis or change, release the corresponding acidic substances, if contact with biological systems, or stimulate tissue, interfere with physiological processes.
Furthermore, the presence of carbonylphenyl adds a reaction check point for the molecule. Carbonyl is electrophilic, or reacts with nucleophiles in organisms to cause changes in the structure and function of biomolecules. When this strange substance is used in specific fields, its safety needs to be investigated in detail. If it is used in medicine, its cytotoxicity, metabolic pathways in vivo and potential side effects need to be studied; when it is used in the field of materials, its stability and release effects in different environments should also be investigated. In short, the safety of this substance cannot be hidden in one word, and it needs to be deeply explored in many aspects to get the whole picture.