2-(methoxycarbonyl)pyridine

2-%28methoxycarbonyl%29pyridine is 2 - (methoxycarbonyl) pyridine, and its physical properties are as follows:
This substance is usually a colorless to light yellow liquid, with a special smell, its taste is difficult to describe exactly, and it seems to have a weak special smell of pyridine compounds. The boiling point is about 212 - 214 ° C. At this temperature, liquid 2 - (methoxycarbonyl) pyridine will transform into a gaseous state. The relative density is about 1.14 (20 ° C), which means that under the same conditions, its density is slightly higher than that of water. If it is mixed with water, it will sink to the bottom. The refractive index is about 1.521 - 1.523. When light passes through the substance, it will be deflected according to this refractive index.
2- (methoxycarbonyl) pyridine is slightly soluble in water. Due to its molecular structure, the presence of pyridine rings and methoxycarbonyl groups makes it difficult to form extensive and stable interactions with water molecules, so the degree of solubility in water is limited. However, it can be miscible with common organic solvents such as ethanol, ether, chloroform, etc. In these organic solvents, by virtue of inter-molecular van der Waals forces, dipole-dipole interactions, etc., it can uniformly disperse to form solutions.
In terms of stability, under normal temperature and pressure and general storage conditions, 2- (methoxycarbonyl) pyridine is relatively stable, and it is not easy to decompose or other violent chemical reactions on its own. However, it is necessary to avoid contact with strong oxidizing agents, strong bases, and other substances, because strong oxidizing agents may initiate oxidation reactions and change their molecular structure; strong bases may react with methoxycarbonyl groups, causing changes in the chemical properties of substances and affecting their original uses and characteristics.

2 - (methoxycarbonyl) pyridine is a kind of organic compound. Its chemical properties are interesting and have important uses.
Let's talk about its physical properties first. This substance is either liquid or solid at room temperature, depending on the surrounding environmental conditions. The value of its melting boiling point is closely related to the intermolecular forces. Because the molecule contains methoxycarbonyl and pyridine ring structures, there are such things as van der Waals forces and dipole-dipole interactions between molecules, which affect its melting boiling point.
Discussing chemical properties, the existence of pyridine rings makes this compound exhibit unique properties. Pyridine rings are aromatic, electron-rich, and prone to electrophilic substitution reactions. However, due to the electron-withdrawing effect of methoxy carbonyl, the electron cloud density of the pyridine ring decreases, and the activity of the electrophilic substitution reaction is slightly lower than that of the pyridine itself. In the electrophilic substitution reaction, the substituent often enters the β-position of the pyridine ring, because the electron cloud density at this position is relatively high, the activation energy of the reaction can be reduced.
Methoxy carbonyl moiety, active in nature. The ester group can undergo hydrolysis reaction. Under acidic or basic conditions, the hydrolysis reaction rate is different. Hydrolysis under acidic conditions is a reversible reaction, resulting in 2-pyridinecarboxylic acid and methanol; hydrolysis under basic conditions is irreversible, resulting in 2-pyridinecarboxylate and methanol. This reaction is often used in organic synthesis to prepare 2-pyridinecarboxylic acid derivatives.
In addition, in 2- (methoxycarbonyl) pyridine molecules, the pyridine nitrogen atom has lone pair electrons and can be used as a ligand to form complexes with metal ions. This property is of great significance in the field of catalysis. The formed complexes can be used as catalysts to catalyze many organic reactions and improve the reaction rate and selectivity. < Br >
2- (methoxycarbonyl) pyridine has rich and diverse chemical properties and plays a key role in organic synthesis, catalysis and other fields. It is an important substance for organic chemistry research and practical applications.

2-%28methoxycarbonyl%29pyridine is 2 - (methoxycarbonyl) pyridine, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Compounds with complex structures and unique functions can be derived through various chemical reactions. For example, under specific catalyst and reaction conditions, it can condensate with other substances containing active groups to form new carbon-carbon bonds or carbon-heteroatomic bonds, thereby constructing complex organic molecular structures, laying the foundation for the creation of organic materials and drugs with special properties.
In the field of medicinal chemistry, 2 - (methoxycarbonyl) pyridine and its derivatives exhibit potential biological activity. Studies have found that some of the compounds with this as the core structure have inhibitory or activating effects on specific disease-related targets. For example, in the development of some anti-tumor drugs, the introduction of this structural unit, after modification and optimization, can improve the targeting and efficacy of the drug on tumor cells, while reducing the toxic and side effects on normal cells.
In the field of materials science, it also has applications. By connecting it to the main chain or side chain of the polymer through chemical reaction, it can endow the material with special physical and chemical properties. For example, to enhance the stability and solubility of the material, or to make it have specific optical and electrical properties, it can play a role in optoelectronic devices, polymer material modification, etc., and help the development and application of new functional materials.

To prepare 2 - (methoxycarbonyl) pyridine, the following synthesis methods can be used.
First, pyridine - 2 - carboxylic acid is used as the starting material. Mix pyridine - 2 - carboxylic acid with methanol, add an appropriate amount of concentrated sulfuric acid as a catalyst, and heat to perform an esterification reaction. During this process, the carboxyl group of pyridine - 2 - carboxylic acid and the hydroxyl group of methanol are condensed, and a molecule of water is removed, so 2 - (methoxycarbonyl) pyridine is obtained. After the reaction is completed, the sulfuric acid is neutralized in sodium bicarbonate solution, and the product is purified by separation and distillation.
Second, 2 - chloropyridine can be started. First, 2-chloropyridine reacts with carbon monoxide and methanol at a certain temperature and pressure in the presence of suitable catalysts (such as palladium catalysts) and bases (such as potassium carbonate). This is a carbonylation reaction, in which the chlorine atom of 2-chloropyridine is replaced by a methoxycarbonyl group to form the target product 2 - (methoxycarbonyl) pyridine. After the reaction is completed, the product is separated and purified by extraction, column chromatography and other means.
Third, 2-cyanopyridine is used as the raw material. 2-cyanopyridine and methanol are catalyzed by an acid (such as sulfuric acid) for alcoholysis. The cyanyl group is first hydrolyzed to a carboxyl group, and then esterified with methanol to obtain 2- (methoxycarbonyl) pyridine. The purified product is obtained by conventional separation methods.
All synthesis methods have their own advantages and disadvantages. In practice, the appropriate method should be carefully selected according to the availability of raw materials, the difficulty of reaction conditions, and the purity requirements of the product.

2-%28methoxycarbonyl%29pyridine is 2- (methoxycarbonyl) pyridine. When storing and transporting this substance, many matters need to be paid attention to.
Its chemical properties are active, and the storage place must be cool, dry and well ventilated. Because it is sensitive to air and moisture, it should be strictly sealed to prevent reactions and deterioration with water vapor and oxygen in the air.
When transporting, it must be carried out in accordance with the relevant hazardous chemical regulations. Due to its irritation and toxicity, the transportation container must be strong and airtight to ensure that there is no risk of leakage. During handling, operators should wear protective equipment, such as protective clothing, gloves and goggles, to avoid skin contact and inhalation.
In addition, whether it is storage or transportation, keep away from fire sources, heat sources and oxidants. This substance is exposed to open flames, hot topics or mixed with oxidants, or there is a risk of combustion and explosion. At the same time, the storage and transportation areas should be equipped with corresponding fire and leakage emergency treatment equipment. In the event of an accident, it can be responded to in time to reduce the harm. In short, the storage and transportation of 2 - (methoxycarbonyl) pyridine should be treated with caution and operated strictly in accordance with regulations to ensure the safety of personnel and the environment from pollution.