2-methoxy-pyridine-5-carboxylic acid

2-Methoxy-pyridine-5-carboxylic acid, this is an organic compound. It has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry to synthesize drug molecules with specific biological activities. The presence of the gaipyridine ring and methoxy and carboxyl groups endows the compound with unique chemical properties and reactivity. It can be spliced with other compounds through various chemical reactions to construct drugs with complex structures and biological functions.
In the field of materials science, it may also have its uses. It can be chemically modified to prepare functional materials, such as for the preparation of sensor materials with the ability to recognize specific substances. By virtue of its structural properties, it interacts specifically with the target substance to achieve the detection of specific substances.
Furthermore, in the study of organic synthesis, 2-methoxy-pyridine-5-carboxylic acids can be used as starting materials or reagents to participate in many organic reactions, providing the possibility for the synthesis of new organic compounds, assisting the development of organic synthetic chemistry, expanding the variety and properties of organic compounds, and meeting the needs of different fields.

2-Methoxy-pyridine-5-carboxylic acid, which is white to off-white crystalline powder. Its melting point is quite high, about 180-185 ° C. Such a high melting point makes it stable under normal temperature environments, and it is not easy to change its state due to temperature fluctuations.
In terms of solubility, it is slightly soluble in water, but it has good solubility in organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). In dichloromethane, by virtue of the interaction between its molecules and dichloromethane molecules, it can be uniformly dispersed in a certain proportion to achieve good solubility. In DMF, the solubility is more considerable due to the strong polarity of DMF and the formation of hydrogen bonds between 2-methoxy-pyridine-5-carboxylic acid molecules.
Its density is about 1.3g/cm ³, which makes it exhibit a specific behavior when participating in some processes involving phase separation or mixing. In terms of chemical stability, it can remain relatively stable under conventional acid-base conditions, but if it is in an extreme environment of strong acids or bases, its pyridine ring and methoxy and carboxyl groups may react, resulting in molecular structure changes.
In addition, it is chemically stable at room temperature and pressure, but if it encounters high temperatures, open flames or strong oxidants, it may cause chemical reactions, and even pose potential dangers such as combustion and explosion. These physical properties are key factors to consider when applying this substance in many fields such as chemical synthesis and drug development, which deeply affects its use and process design.

The synthesis method of 2-methoxy-pyridine-5-carboxylic acid is not directly described in the ancient book "Tiangong Kaiwu", but it can be deduced from the ancient method.
First, it can be started from the raw material containing the pyridine ring. Find suitable pyridine derivatives with convertible groups at the 2nd and 5th positions of the pyridine ring. Such as 2-hydroxy-pyridine-5-carboxylic acid, to obtain a methoxy group, the hydroxyl group can be reacted with halomethane in an alkaline environment. For bases, such as potassium carbonate, it is appropriate to choose iodomethane for halogenated methane. Under these conditions, the hydroxyl nucleophilic group attacks the methyl group of iodomethane, and the iodine ions leave, and then form the precursor of 2-methoxy-pyridine-5-carboxylic acid. After proper purification, the target product can be obtained.
Second, pyridine-5-carboxylic acid can also be used as the starting material. First, pyridine-5-carboxylic acid reacts with dimethyl sulfate in the presence of a basic catalyst. Sodium hydroxide can be used as the base, and dimethyl sulfate provides the methoxy group, and methoxylation occurs at the second position of the pyridine ring. During the reaction, the temperature should be appropriate, and side reactions should not be caused by too high, and the reaction should not be too low to slow down. After this reaction, the product is isolated and purified, and 2-methoxy-pyridine-5-carboxylic acid can also be obtained.
Third, pyridine-2,5-dicarboxylic acid can also be used. To convert its carboxyl group into methoxy group by appropriate methods, one carboxyl group can be esterified first, and then another carboxyl group can be reduced to alcohol with a specific reducing agent, then halogenated, and then reacted with sodium methoxide to introduce methoxy group. Finally, hydrolysis, oxidation and other steps are taken to obtain the target 2-methoxy-pyridine-5-carboxylic acid. Each step requires fine control of the reaction conditions to achieve the purpose of efficient synthesis.

The price of various substances in the market often changes due to differences in market conditions, materials, and sources, making it difficult to determine the price of 2-methoxy-pyridine-5-carboxylic acid. This compound may have applications in chemical and pharmaceutical research and development, and its price may be influenced by various reasons.
If the preparation method is difficult, multiple processes are required, and rare materials are used, the price will be high. If it is widely sought in the market, the supply is less and more, and the price will rise; conversely, if the preparation is easy, the supply will exceed the demand, and the price will drop.
Looking at "Tiangong Kaiwu", its records of various process products are not as good as this 2-methoxy-pyridine-5-carboxylic acid. With common sense, the price of such fine chemicals may range from a few to several hundred yuan per gram. However, this is only speculation, and the actual price should be consulted by chemical raw material suppliers and reagent sellers. The price of chemical products in the city often changes with time, and buyers must consult in person before they can determine the price.

2-Methoxy-pyridine-5-carboxylic acid is one of the organic compounds. Its storage conditions are related to its stability and quality, which cannot be ignored.
This compound should be stored in a cool place. High temperature can easily cause its molecular movement to intensify, or cause chemical reactions, which damage its structure and properties. Extreme heat at room temperature is not suitable, so a cool place can slow down its change.
and must be placed in a dry place. Due to moisture or moisture, it can interact with the compound. Water may cause it to hydrolyze, break its chemical bonds, and change the composition and properties of the compound. To keep the environment dry and avoid the risk of hydrolysis. < Br >
Furthermore, it should be stored in a well-ventilated place. If the air is not ventilated, the gas or accumulation emitted by the compound may not only endanger the environment, but also cause safety problems due to high concentration. Ventilation can allow harmful gases to escape and ensure the safety of the storage environment.
It must also be kept away from fire and heat sources. This compound may be flammable, and in case of fire or high temperature, it may pose a risk of combustion or even explosion. Fire and heat sources are the source of accidents, and farther away can reduce the occurrence of accidents.
When storing, it should also be stored separately from oxidizing agents, acids, alkalis and other substances. These substances are chemically active, and contact with 2-methoxy-pyridine-5-carboxylic acid can easily trigger chemical reactions, or cause violent reactions, endangering safety.
Storage containers should also be carefully selected. Containers with good sealing performance should be used to prevent compound volatilization, leakage, and to prevent the intrusion of external substances. Containers made of glass or plastic are available if they can meet the chemical stability requirements.
In summary, 2-methoxy-pyridine-5-carboxylic acids should be stored in a cool, dry, well-ventilated place, away from fire and heat sources, and separately from incompatible substances, in a suitable container for sealed storage, so as to ensure its quality and safety.