2-METHOXY-5-PYRIDINECARBONITRILE

2-Methoxy-5-pyridinitrile is one of the organic compounds. It has a wide range of uses and can play an important role in many fields.
First, in the field of medicinal chemistry, this compound is often a key intermediate for the synthesis of drugs. The creation of many drugs requires modification and transformation of their specific structures to obtain substances with specific pharmacological activities. Due to the characteristics of its structure, it can participate in various chemical reactions, help build the core structure of drug molecules, and then realize the therapeutic or preventive effect of diseases.
Second, in the field of materials science, 2-methoxy-5-pyridinitrile also has a place. Or it can be used to prepare functional materials with specific properties, such as photovoltaic materials. Because its molecular structure can affect the key properties such as electron transport and optical properties of materials, it can be properly designed and synthesized to endow materials with unique photoelectric properties, which can show potential application value in optoelectronic devices such as Light Emitting Diodes and solar cells.
Furthermore, in organic synthetic chemistry, as an important building block, it can participate in a variety of organic reactions, such as nucleophilic substitution, cyclization, etc. With its specific functional groups and reactivity, chemists can use it to construct more complex organic molecular structures, expand the types and functions of organic compounds, and provide an important material basis and reaction path for the development of organic synthetic chemistry.

2-Methoxy-5-pyridineformonitrile is one of the organic compounds. This substance has specific physical properties and is very important in the field of organic synthesis.
Looking at its properties, 2-methoxy-5-pyridineformonitrile is mostly solid at room temperature and pressure, but its exact appearance may vary depending on purity and crystallization conditions, or it is a white to light yellow crystalline powder.
When it comes to melting point, the melting point of this compound is about [X] ° C. As an important indicator for identification and purity determination, melting point is of great significance in the research and production of this compound. Due to the accurate determination of the melting point, it can help to determine the purity. If impurities are mixed in, the melting point will often decrease and the melting range will become wider.
In terms of boiling point, under specific pressure conditions, the boiling point of 2-methoxy-5-pyridineformonitrile is about [X] ° C. The boiling point data plays a guiding role in separation and purification operations such as distillation. Knowing the boiling point can make a reasonable choice of distillation temperature and pressure to achieve efficient separation.
Solubility is also an important physical property. 2-Methoxy-5-pyridineformonitrile exhibits good solubility in organic solvents such as dichloromethane, chloroform, and N, N-dimethylformamide (DMF), but it is difficult to dissolve in water. This solubility characteristic has a profound impact on the choice of reaction solvents and product separation in organic synthesis. For example, when building a reaction system, a suitable organic solvent needs to be selected according to its solubility to ensure full contact of the reactants and improve the reaction efficiency; when the product is separated, the difference in solubility in different solvents can be used to achieve effective separation and purification.
In addition, the physical properties such as density and refractive index of 2-methoxy-5-pyridineformonitrile also have their specific values. The density is related to its distribution and transportation in different media, and the refractive index has certain significance in the research and application of optics. These physical properties are related to each other, and together describe the physical properties of 2-methoxy-5-pyridineformonitrile, which lays a solid foundation for its application in many fields such as organic synthesis and medicinal chemistry.

2-Methoxy-5-pyridineformonitrile is a family of organic compounds. Its physical and chemical properties are unique and of great significance to the field of organic synthesis.
Looking at its physical properties, 2-methoxy-5-pyridineformonitrile is mostly solid at room temperature and pressure, which is easy to store and operate. However, its melting point and boiling point need to be determined by professional experiments due to accurate values, which have not been detailed yet. This property is crucial for the separation and purification of compounds. It can be precisely separated from the mixture by distillation and recrystallization by means of differences in melting point and boiling point.
As for chemical properties, cyano (-CN) is the key activity check point of 2-methoxy-5-pyridyl formonitrile. Cyanyl has high reactivity and can participate in multiple chemical reactions. First, in the hydrolysis reaction, cyano can be gradually converted into carboxyl (-COOH) under the catalysis of acid or base. This reaction provides a way for the preparation of 2-methoxy-5-pyridyl carboxylic acid, which is widely used in the synthesis of medicine and pesticides. Second, when reacting with nucleophiles, the carbon atoms in the cyanyl group are susceptible to attack by nucleophiles due to their partial positive electricity, generating novel compounds and expanding the diversity of molecular structures. The chemical properties of 2-methoxy-5-pyridineformonitrile are also influenced by methoxy (-OCH). Methoxy acts as a power supply group, which can change the electron cloud density distribution of the pyridine ring through conjugation and induction effects, thereby affecting the substitution activity and regioselectivity on the pyridine ring. For example, in electrophilic substitution reactions, the power supply of methoxy groups prompts the reaction to occur more easily at specific locations on the pyridine ring, providing direction guidance for the synthesis of target products.
In conclusion, 2-methoxy-5-pyridinecarbonitrile has great potential in the field of organic synthesis due to its unique physical and chemical properties, which can lay the foundation for the creation of many fine chemicals.

The method for the synthesis of 2-methoxy-5-pyridineformonitrile is described in ancient books and is described below.
One method is to use 5-bromo-2-methoxy pyridine as the starting material. First, heat it with cuprous cyanide in a suitable solvent, such as N, N-dimethylformamide, and azeotrope. Here, cuprous cyanide is used as a nucleophile, replacing the bromine atom, and then 2-methoxy-5-pyridineformonitrile is obtained. During the reaction, the temperature needs to be controlled in a certain range, about 150-180 ° C, and it needs to be protected by inert gas to prevent the oxidation of the raw material and the product. After the reaction is completed, the pure product can be obtained by extraction, column chromatography and other methods.
There is another method, starting with 2-hydroxy-5-pyridineformonitrile. React it with dimethyl sulfate in an alkaline environment. Bases such as potassium carbonate can promote the formation of phenolic hydroxyl negative ions, which in turn undergoes nucleophilic substitution with dimethyl sulfate, and methoxy is introduced to obtain the target product 2-methoxy-5-pyridineformonitrile. The reaction is usually carried out in an organic solvent such as acetone, and the temperature should be controlled at 50-60 ° C. After the reaction is completed, the product is separated and purified by washing with water, drying, distillation and other steps.
Another way is to construct the pyridine as the parent nucleus. Methoxy is introduced at the 2nd position of the pyridine ring first, and cyano is introduced at the 5th position. It can be achieved by a multi-step reaction, such as methoxylation of pyridine with a suitable methoxylation reagent first, and then cyanation. However, this approach is a little complicated, and the reaction conditions of each step need to be carefully adjusted to ensure the selectivity and yield of the reaction.

The price of 2-methoxy-5-pyridineformonitrile in the market is often difficult to determine a precise value due to various reasons. This compound is used differently in various fields of chemical industry. The quantity of purchase, the quality of the product, the time of sale, the place and method of production are all factors of price change.
If deduced from past market conditions, the price of large quantities and high quality may be between a few yuan and tens of yuan per gram at ordinary times. However, in the chemical industry market, the situation is constantly changing, the price of raw materials fluctuates, the regulation of policies, and the state of demand and supply can all make the price change greatly. < Br >
For example, if the price of raw materials rises sharply, the cost of production will increase, and its price in the market will also rise accordingly; or if a new technology is developed, the yield increases greatly, and the supply exceeds the demand, the price may drop. And in different places, due to differences in transportation and taxes, the price is also different. Therefore, in order to know the exact price, you need to carefully check the current market conditions and consult the supplier to obtain a near-real number.