2-Methoxy-5-Picoline (2-Methoxy-5-Methylpyridine)

The main use of 2-methoxy-5-methylpyridine (2-methoxy-5-piperidinyl) is particularly important. This substance is quite useful in the field of medicinal chemistry.
In the pharmaceutical industry, it can be used as a key intermediate. Due to its unique chemical structure, it can combine with other compounds through various chemical reactions to obtain drug molecules with specific pharmacological activities. For example, it can be used to synthesize drugs for the treatment of nervous system diseases. Neurological diseases are quite complex and difficult to treat, and drugs made from this raw material may be helpful for the repair of nerve cells and the regulation of neurotransmitters.
In the field of organic synthesis, it is also an important cornerstone. Organic synthesis aims to create organic compounds with complex structures and specific properties. 2-methoxy-5-methylpyridine (2-methoxy-5-piperidinyl) can participate in many organic reactions, such as nucleophilic substitution reactions, oxidation reactions, etc. Through these reactions, chemists can build more complex chemical structures, paving the way for the development of new materials.
And in the field of materials science, it may also emerge. Materials science is concerned with the exploration and optimization of new materials. This compound may endow materials with special physical and chemical properties, such as improving the stability and conductivity of materials, thus providing new opportunities for the development of electronic devices, polymer materials and many other aspects. In short, 2-methoxy-5-methylpyridine (2-methoxy-5-piperidine) has potential value in many scientific fields.

2-% methoxy-5-methylpyridine (2-methoxy-5-picolin) is an organic compound. Its physical properties are as follows:
- ** Appearance and Properties **: Under normal conditions, it is mostly colorless to light yellow liquid, with a clear and transparent texture. Observed in a well-lit place, it can be seen that its surface reflects a soft luster, and has good flow performance, without a sticky feeling.
- ** Odor **: emits a weak and special smell, which is not pungent or unpleasant, but also has a unique recognition. If mixed with a little aromatic smell and light chemical smell, it can make people feel slightly fresh. < Br > - ** Melting point and boiling point **: The melting point is about -27 ° C. At this temperature, the substance quietly changes from solid to liquid, as if melting ice and snow. The boiling point is between 171 and 172 ° C. When the temperature rises to this range, the liquid will boil sharply and rise into a gaseous state.
- ** Solubility **: It can be miscible with many organic solvents, such as ethanol, ether, etc. In ethanol, the two are like water emulsion, forming a uniform and stable solution. However, its solubility in water is quite limited, only a little can be dissolved. When it drops into water, some will float on the water surface, and some will slowly spread, but it is difficult to completely dissolve, showing a delicate phase separation state. < Br > - ** Density **: The density is about 1.045g/cm ³, which is slightly greater than the density of water. Placing it in the same container as water shows that it sinks steadily and accumulates quietly at the bottom.
- ** Stability **: Under normal temperature and pressure and no special chemical reaction conditions, the substance is quite stable, the molecular structure is solid, and it is not easy to decompose or other violent reactions on its own. When encountering open flames or hot topics, it is potentially dangerous and may cause combustion. It needs to be properly stored and used, away from fire sources and high temperature environments.

The chemical properties of 2-methoxy-5-methylpyridine (2-methoxy-5-picoline) are quite stable. In this compound, the methoxy group interacts with the methylpyridine structure, giving it specific chemical properties. In the
methoxy group, the oxygen atom has a lone pair of electrons, which can form a conjugation effect with the pyridine ring, which enhances the stability of the electron cloud density distribution of the molecule. And the electron-giving effect of the methoxy group changes the electron cloud density at a specific position on the pyridine ring, affecting its electrophilic substitution activity, and therefore stabilizes the molecular structure.
Furthermore, although the presence of 5-methyl has relatively little effect on the electron cloud density of the pyridine ring, its steric hindrance effect hinders the proximity of external reagents to the specific position of the pyridine ring to a certain extent, further enhancing molecular stability.
From the perspective of reactivity, the nitrogen atom of the pyridine ring has a lone pair of electrons, which can be used as a nucleophilic check point to participate in the reaction. However, due to the existence of methoxy and methyl groups, the reaction needs to overcome certain spatial and electronic effects, which is not very easy to occur. Therefore, in a common chemical environment, 2-methoxy-5-methylpyridine is not prone to spontaneous and violent chemical reactions, and its chemical properties are relatively stable. It can maintain its own chemical structure under normal temperature and pressure and general chemical environments.

To prepare 2-methoxy-5-methylpyridine (2-methoxy-5-picolin), there are three methods.
First, use 2-chloro-5-methylpyridine and sodium methoxide as raw materials, in a suitable solvent, heat the reaction. This reaction requires attention to the choice of solvent. Commonly used non-protic solvents such as toluene and xylene can make the reaction proceed smoothly. During the reaction, the temperature should be controlled at 100-130 ° C. Over time, the product can be obtained by separation and purification. The raw materials in this way are relatively easy to obtain, but the reaction conditions are slightly harsh. It is necessary to pay attention to the activity and dosage of sodium methoxide, otherwise the yield will be affected.
Second, 5-methyl-2-hydroxypyridine is reacted with dimethyl sulfate. First dissolve 5-methyl-2-hydroxypyridine in an alkali solution, such as sodium hydroxide or potassium carbonate solution, and then slowly add dimethyl sulfate. The reaction temperature should be low, starting at 0-5 ° C, and then gradually rising to room temperature. The reaction conditions of this method are relatively mild, but dimethyl sulfate is toxic, so caution and protection should be taken during operation. After the reaction, the pure product is obtained through extraction, distillation and other steps.
Third, using 2,5-dimethylpyridine as raw material, first oxidize to oxidize the 2-position methyl group to a hydroxyl group, and then react with dimethyl sulfate to form a methoxy group. The oxidation step can be reacted with an oxidizing agent such as potassium permanganate or potassium dichromate in an appropriate solvent and temperature. The subsequent methoxylation reaction is the same as the previous method. This path step is slightly complicated, but the raw material 2,5-dimethylpyridine has a wide range of sources. Each step of the reaction requires fine control of conditions to obtain satisfactory yield and purity.

In today's world, the market is complex, and the price of goods often varies with time, place and quality. However, it is not easy to know the price range of "2-methoxy-5-methylpyridine (2-methoxy-5-picolin) " in the market. The price of these fine chemical products is affected by many factors.
First, the price of raw materials has a great impact. If the methoxy, methyl and other related raw materials required for the synthesis of this substance are difficult to obtain, whether they are abundant or not, the cost fluctuates, and then the price of finished products is different.
The difference in process is also the key. Sophisticated methods can increase the rate of output and increase the quality of products, but they may require exquisite techniques or expensive tools, and the cost will be high. Simple methods, although the cost may be low, may have deficiencies in quality and quantity. Produced by different processes, the price in the market varies from high to low.
Furthermore, the supply and demand of the city is also the main reason. If at a certain time and place, there are many applicants for this product, but there are few suppliers, the price will rise; on the contrary, if the supply exceeds the demand, the price will fall from the moment.
In addition, regional differences, changes in taxes, and transportation costs are all factors that affect the price.
Overall, the market price of this "2-methoxy-5-methylpyridine (2-methoxy-5-picolin) ", or due to the above factors, the price per kilogram can range from hundreds to thousands of gold, which is difficult to determine. If you want to know the details, you need to consult chemical merchants, industry experts, or you can get close to its true price.