2-Methoxy-5-fluoropyridine-3-carbaldehyde

2-Methoxy-5-fluoropyridine-3-formaldehyde has a wide range of uses. In the field of medicinal chemistry, it is a key organic synthesis intermediate. In the process of many drug research and development, it is necessary to build a specific molecular structure to give the drug ideal pharmacological activity. For example, when some new antibacterial drugs are created, 2-methoxy-5-fluoropyridine-3-formaldehyde can be integrated into drug molecules through a series of chemical reactions to enhance the affinity and inhibition of drugs against specific bacteria, contributing to the development of antibacterial drugs.
It also has important uses in the field of materials science. In the preparation of organic optoelectronic materials, its unique structure can participate in the construction of special conjugated systems, which affects the photoelectric properties of materials. Through chemical modification and reaction regulation, organic materials with specific luminescence and electrical conductivity can be prepared for organic Light Emitting Diode (OLED), solar cells and other devices, improving device performance and efficiency, and injecting vitality into the development of materials science.
In addition, in the field of fine chemicals, 2-methoxy-5-fluoropyridine-3-formaldehyde can be used to synthesize various fine chemicals, such as special fragrances, additives, etc. Due to its unique structure, it can endow fine chemicals with special properties and functions, meeting the needs of different industries and playing an important role in the fine chemical industry.

There are several common methods for synthesizing 2-methoxy-5-fluoropyridine-3-formaldehyde.
First, a compound containing a pyridine structure is used as the starting material. An appropriate pyridine derivative can be found, which has a chemically convertible functional group at a specific position. For example, select a halogen atom at the corresponding position and introduce a methoxy group by a nucleophilic substitution reaction. First, the halogenated pyridine derivative is co-placed with a nucleophilic reagent such as sodium methoxide in a suitable reaction solvent, such as N, N-dimethylformamide (DMF). At an appropriate temperature, the halogen atom is substituted with the methoxy group to form a methoxy-containing pyridine intermediate. Then, for the introduction of fluorine atoms, suitable fluorinating reagents, such as Selectfluor, etc., can be used to fluorinate the intermediate at the designated position under specific reaction conditions to obtain a pyridine compound containing methoxy and fluorine atoms. Finally, through a mild formylation reaction, such as the use of Vilsmeier-Haack reagent composed of N, N-dimethylformamide (DMF) and phosphorus oxychloride (POCl), the above compounds are reacted at low temperature, and then hydrolyzed to introduce formyl groups at the 3-position of the pyridine ring to obtain 2-methoxy-5-fluoropyridine-3-formaldehyde.
Second, to construct a strategic synthesis of pyridine rings. Start from suitable non-pyridine starting materials, such as by multi-step reaction to construct pyridine rings. Pyridine ring skeletons can be constructed by condensation of 1,5-dicarbonyl compounds with ammonia or amine compounds under acidic catalysis. During the construction process, the order of introduction of substituents can be pre-designed. For example, methoxy-substituted groups are introduced first, and in a suitable step, the methoxy group is connected to the corresponding position by nucleophilic substitution or other suitable reactions. After the formation of the pyridine ring, fluorine atoms are introduced by a specific fluorination method, and then formyl groups are introduced in the above-mentioned formylation reaction steps to finally obtain the target product 2-methoxy-5-fluoropyridine-3-formaldehyde. Although this method is a little complicated, it can flexibly adjust the position and type of substituents, which is quite advantageous for the synthesis of pyridine derivatives with specific structures.

2-Methoxy-5-fluoropyridine-3-formaldehyde is a kind of organic compound. Its physical properties are quite critical, and its applications in chemical, pharmaceutical and other fields also depend on this property.
Looking at its properties, at room temperature, this substance is mostly solid, or white to white crystalline powder with uniform and delicate texture. This form is easy to store and transport, and is also conducive to subsequent processing.
When it comes to melting point, 2-methoxy-5-fluoropyridine-3-formaldehyde has a specific melting point range. Accurate determination of melting point can help to distinguish its purity. In general, the melting point of high-purity products is sensitive and stable. The determination of the melting point is of great significance in the quality control process to ensure that the product meets the established standards.
In terms of solubility, this substance exhibits a certain solubility in organic solvents such as dichloromethane, chloroform, N, N-dimethylformamide (DMF). In dichloromethane, it can be well dissolved to form a uniform solution, which facilitates the organic synthesis reaction. Due to the fact that many organic reactions are carried out in solution systems, good solubility allows the reactants to be fully contacted and promotes the smooth development of the reaction. < Br >
However, its solubility in water is not good, because there are relatively few hydrophilic groups in the molecular structure, while hydrophobic pyridine rings, methoxy groups, fluorine atoms, etc. dominate, resulting in weak interaction with water.
The physical properties of 2-methoxy-5-fluoropyridine-3-formaldehyde, whether it is appearance, melting point, or solubility, affect its application in different fields. In organic synthesis, choose the appropriate reaction solvent according to its solubility; judge the purity by the melting point to ensure the reaction effect and product quality.

2-Methoxy-5-fluoropyridine-3-formaldehyde, this is an organic compound with unique chemical properties and considerable research value.
From the structural point of view, its pyridine ring is connected with methoxy, fluorine atoms and aldehyde groups. Methoxy groups, as power supply groups, can enhance the electron cloud density of the pyridine ring and affect its chemical activity. Fluorine atoms have high electronegativity, which can change the electron distribution and spatial configuration of molecules, thereby affecting the stability and reactivity of compounds. Aldol groups are active functional groups and can participate in many chemical reactions.
In nucleophilic addition reactions, the carbon-oxygen double bond of the aldehyde group is susceptible to attack by nucleophilic reagents due to the partial positive charge of the carbon belt. For example, acetals can be formed with alcohols under acid catalysis. When encountering Grignard's reagent, nucleophilic addition occurs to form new carbon-carbon bonds, which is an important method for building carbon skeletons in organic synthesis.
In redox reactions, aldehyde groups can be oxidized to carboxylic groups. With mild oxidizing agents such as Torun's reagent or Feilin's reagent, it can be oxidized to corresponding carboxylic acids. This property is often used for qualitative testing of aldehyde groups. It can also be reduced. If treated with reducing agents such as sodium borohydride or lithium aluminum hydride, the aldehyde group can be converted into alcohol hydroxyl groups.
In the aromatic ring substitution reaction, although the fluorine atom has a large electronegativity due to the methoxy group being the ortho and para-position group, it will also affect the electrophilic substitution reaction check point on the pyridine ring due to its special p-π conjugation effect. Electrophilic reagents tend to attack the ortho and para-position of the methoxy group, and other functional groups can be introduced according to this characteristic to expand the structure and function of the compound.
In addition, the physical properties of 2-methoxy-5-fluoropyridine-3-formaldehyde, such as melting point, boiling point, solubility, etc., are also closely related to its chemical structure. Its solubility may be due to the interaction of polar functional groups and aromatic rings in the molecule. It has a certain solubility in some organic solvents such as dichloromethane and ethanol, but limited solubility in water. These physical properties are crucial in the separation, purification and application of compounds.

I have not obtained the exact price of 2-methoxy-5-fluoropyridine-3-formaldehyde on the market. However, the determination of its price depends on many reasons. First, the purity of this compound is essential. High purity, its preparation is difficult and labor costs are huge, and the price must be high; low purity, preparation is easier, and the price may be slightly cheaper. Second, the market supply and demand is also heavy. If the demand for this product exceeds the supply, merchants will raise its price to make a profit; if the supply exceeds the demand, the price may drop. Furthermore, the preparation method and cost also affect its price. Complex and expensive method, high cost and high price; simple and cost-saving method, low cost and low price or low price. In addition, the manufacturer's region, brand, transportation and packaging costs can also vary.
Although I do not know the exact price, if you want to know the price, you can consult the chemical raw material supplier or visit the relevant chemical product trading platform to get the approximate price in the near future. You can also negotiate with the merchant to get a more suitable price.