2 Methoxy 5 Cyanopyridine
pyridine pyrrole pyrazine piperidine piperazine

2-Methoxy-5-cyanopyridine

    Specifications

    HS Code

    523376

    Chemical Formula C7H6N2O
    Molar Mass 134.14 g/mol
    Appearance Solid (usually)
    Color Off - white to light - colored solid
    Odor Typically odorless or faint odor
    Melting Point 114 - 116 °C
    Solubility In Water Low solubility in water
    Solubility In Organic Solvents Soluble in some organic solvents like ethanol, acetone
    Density Approx. 1.24 g/cm³
    Pka No common pKa value reported for this structure in typical conditions
    Stability Stable under normal conditions but may react with strong oxidizing agents

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    General Information
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    Frequently Asked Questions

    As a leading 2-Methoxy-5-cyanopyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-methoxy-5-cyanopyridine?
    2-% methoxy-5-pentylpyridine has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of many effective drugs. Through a specific chemical reaction path, it can be ingeniously integrated into the molecular structure of the drug, giving the drug unique pharmacological activity and therapeutic efficacy.
    Looking at the field of materials science, 2-% methoxy-5-pentylpyridine also plays an important role. It can be added to the polymer material system as a special type of additive. In this way, the physical properties of the material can be significantly improved, such as enhancing the stability, flexibility and durability of the material, thereby broadening the application scenarios of the material.
    In the field of organic synthetic chemistry, as a key structural unit, it can participate in a variety of complex organic reactions and construct organic compounds with special structures and functions, providing an important material basis for the research and development of new organic materials.
    In addition, in the fine chemical industry, it can also be used to prepare some special fragrances, pigments and other fine chemicals, giving products unique odor or color characteristics, and enhancing the quality and added value of products.
    In short, 2-% methoxy-5-pentylpyridine, with its unique chemical structure, has shown important application value in many fields, promoting the technological progress and innovative development of related industries.
    What are the physical properties of 2-methoxy-5-cyanopyridine?
    2-% methoxy-5-alkylpyridine is an important intermediate in organic synthesis. Its physical properties are as follows:
    Looking at its properties, it is mostly colorless to light yellow liquid or solid. This is due to the arrangement and interaction of atoms and groups in the molecule, resulting in a specific aggregation state at room temperature and pressure.
    When it comes to boiling points, the structure of alkyl groups varies depending on the number of carbon atoms. Generally speaking, with the growth of alkyl chains, the intermolecular van der Waals force increases, and the boiling point also increases. If alkyl is methyl, the boiling point is relatively low; if it is a longer alkyl chain, such as n-butyl, the boiling point will increase significantly.
    In terms of melting point, it is also affected by alkyl groups. When the alkyl group structure is regular and the symmetry is good, the molecular arrangement is tight, the lattice energy is increased, and the melting point is correspondingly increased. On the contrary, if the alkyl structure has many branches, poor symmetry, loose molecular arrangement, the melting point will be reduced.
    In terms of solubility, 2-methoxy-5-alkylpyridine is slightly soluble in water. Although methoxy groups in its molecules can form hydrogen bonds with water molecules, the pyridine ring and alkyl group are hydrophobic groups, and the interaction with water is generally weak. However, it is soluble in common organic solvents such as ethanol, ether, chloroform, etc. Due to the interaction between these organic solvents and 2-methoxy-5-alkylpyridine molecules through van der Waals forces, good miscibility can be achieved.
    Density is also related to alkyl, generally slightly higher than or similar to water. This is due to the unit volume mass determined by the type, number and spatial arrangement of atoms in the molecule.
    In terms of volatility, it varies depending on the boiling point. Low-boiling compounds of this type are relatively volatile and easy to diffuse in air.
    In summary, the physical properties of 2-methoxy-5-alkylpyridine are significantly affected by the alkyl structure, and these properties are of great significance in many fields such as organic synthesis, separation and purification, and provide a basis for the rational use of this compound.
    What are the synthesis methods of 2-methoxy-5-cyanopyridine?
    To prepare 2-methyl-5-heptylpyridine, there are three methods.
    First, the corresponding halogenated hydrocarbons and pyridine derivatives are used as raw materials. Take the halogenated 2-methyl compound and 5-halogenated heptylpyridine, put them in a special ceramic kettle, add an appropriate amount of alkali and a specific catalyst, simmer slowly, and control the heat to a suitable degree. During this process, the halogenated hydrocarbon atom and the corresponding check point of the pyridine derivative undergo nucleophilic substitution reaction. The two are cleverly connected and gradually become the target product. This process requires fine regulation of temperature and time, otherwise side reactions will easily occur and the product will be impure.
    Second, by the method of Grignard reagent. First, the heptyl Grignard reagent is carefully prepared by halogenated heptane and magnesium chips in an anhydrous ether environment. This reagent is very active and needs to be properly preserved. Take 2-methyl-5-halogenated pyridine, slowly drop heptyl Grignard reagent into it, and react in a low temperature environment. When the reaction is stable and gradually heated to a moderate temperature, the heptyl part of the Grignard reagent is like a smart messenger, combining with a specific check point on the pyridine to complete the construction of the target product. This process requires strict requirements for anhydrous and anaerobic conditions, and the Grignard reagent is prone to failure if there is a little carelessness.
    Third, the coupling reaction catalyzed by transition metals. Select suitable transition metal catalysts, such as complexes of palladium and nickel, and combine them with ligands to form an active catalytic system. Using 2-methyl pyridine derivatives and 5-haloheptane as reactants, in a specific solvent, under the action of the catalytic system, the two can achieve efficient coupling. This method has relatively mild conditions and high product selectivity, but the catalyst is expensive and costly.
    What are the precautions for storing and transporting 2-methoxy-5-cyanopyridine?
    There are many things to pay attention to when storing and transporting 2-% methoxy-5-pentylpyridine.
    This chemical may be more active in nature. When storing, the first thing to do is to choose a dry and cool environment. Because it may be sensitive to humidity and temperature, humidity or high temperature can cause it to deteriorate, damaging quality and performance. Be sure to place it in a sealed container to prevent excessive contact with air and cause reactions such as oxidation. And it should be kept away from fire and heat sources. Because it may be flammable, it may cause fire if it is not careful.
    When transporting, it is also necessary to exercise caution. Regulations for the transportation of hazardous chemicals must be followed. Packaging must be sturdy and well sealed to withstand bumps and collisions during transportation and avoid leakage. Transportation vehicles should also be equipped with corresponding fire and emergency equipment for emergencies. Transportation personnel must be professionally trained and familiar with the characteristics of the chemical and emergency treatment methods.
    At the same time, whether it is stored or transported, it should be marked. Clearly mark its name, nature, hazard category and other key information so that relevant personnel can identify and deal with it. If any abnormalities are detected during storage or transportation, such as leaks, odors, etc., emergency measures should be taken immediately, personnel should be evacuated, and professionals should be notified quickly to deal with it. Do not take it lightly to avoid serious safety and environmental hazards.
    What are the safety risks associated with 2-methoxy-5-cyanopyridine?
    2-% methoxy-5-benzylpyridine is a chemical substance. It is related to its safety risk and needs to be analyzed from multiple aspects such as toxicity, explosion, and environment.
    In terms of toxicity, this chemical substance may be toxic to a certain extent. Its oral, inhalation, or skin contact with the human body may be harmful to health. For example, oral ingestion, or irritation of the stomach, causing nausea, vomiting, abdominal pain, etc.; inhalation, or irritation of the respiratory tract, causing cough, asthma, and even damage to the lungs; contact with the skin, or causing allergies, redness, swelling, and itching.
    In terms of explosion risk, its chemical structure contains specific groups, or it is flammable. In case of open flame, hot topic, or cause combustion, if it reaches a certain concentration in a limited space, there may be a risk of explosion. And when burning, toxic fumes may be released, endangering on-site personnel and the environment.
    Environmental risks cannot be ignored. If it enters the environment, diffuses through water flow and atmosphere, or pollutes soil, water, and air. It degrades slowly in the environment, or remains for a long time, accumulates in the living body, passes through the food chain, affects the ecological balance, and is toxic to animals and plants.
    Another transportation and storage link, if the packaging is damaged, the storage conditions are improper, such as uncomfortable temperature and humidity, or causes it to leak and deteriorate, increasing the risk.
    In summary, 2-% methoxy-5-benzylpyridine poses safety hazards in all aspects of use, transportation, and storage. It is necessary to operate in strict accordance with safety procedures and take protective measures to reduce the risk.