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What are the chemical properties of 2-methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine
2-Methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxoboran-2-yl) pyridine, an organic compound. Its chemical properties are unique, let me tell you in detail.
From the structural point of view, the compound contains a pyridine ring, which is aromatic and gives it a certain stability. The nitrogen atom of the pyridine ring is rich in electrons and can participate in many chemical reactions, such as coordinating with metal ions to form complexes, which is widely used in the field of catalysis.
Its methoxy group (-OCH) is attached to the pyridine ring, which is the power supply group, which can affect the electron cloud density distribution of the pyridine ring, making the specific position on the ring more prone to electrophilic substitution. For example, electrophilic reagents are more inclined to attack the ortho and para-methoxy groups, and the electron cloud density of the ortho and para-methoxy groups is relatively increased due to the methoxy power supply.
Furthermore, the 4,4,5,5-tetramethyl-1,3,2-dioxoboramyl-2-group connected to the 4-position is a reactive group. Boron atoms are electron-deficient, and this structure is often used as a key intermediate in organic synthesis. It can participate in the coupling reaction of Suzuki, which is coupled with halogenated aromatics or olefins under palladium catalysis to form carbon-carbon bonds, which is an important means for the synthesis of complex organic molecules.
In addition, under appropriate conditions, the compound can break the boron-oxygen bond and participate in other types of reactions, resulting in various chemical transformations. Its physical properties are also related to its structure. Because the molecule contains polar groups, it should have a certain solubility in polar solvents, and the alkyl part makes it have a certain lipid solubility. This property affects its behavior in different solvent systems and is of great significance for its separation, purification and application.
What are the common synthesis methods of 2-methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine
2-Methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine is an important intermediate in organic synthesis. The common synthesis methods are as follows:
The starting material is usually 2-methoxy-4-halopyridine and pinacol borane, and the coupling reaction catalyzed by transition metals is used to achieve the synthesis. The boration reaction catalyzed by palladium is a classic method. In this reaction, the halogen atom on the halopyridine is coupled with the boron atom of pinacol borane under the action of palladium catalyst to form the target product.
Generally speaking, 2-methoxy-4-halo-pyridine, pinacol borane, palladium catalyst (such as tetra (triphenylphosphine) palladium, etc.), base (such as potassium carbonate, sodium carbonate, etc.), placed in a suitable organic solvent (such as dioxane, toluene, etc.), and stirred under heating conditions. The reaction temperature is mostly controlled between 80-120 ° C, and the reaction time may take several hours or even ten hours, depending on the specific reaction conditions. After the reaction is completed, the pure 2-methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine product is obtained through separation and purification steps, such as column chromatography and recrystallization.
In addition, there are other synthesis strategies, such as using 2-methoxypyridine as the starting material, modifying the pyridine ring first, and then introducing the boron ester group. However, compared with the palladium-catalyzed boration reaction, these methods or steps are more complicated and the yield may not be satisfactory. Therefore, the palladium-catalyzed boration reaction has become a common method for the synthesis of 2-methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine due to its high efficiency and convenience.
In which fields is 2-methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine used?
2-Methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxyboron-heterocyclopentane-2-yl) pyridine, this compound is used in many fields such as medicinal chemistry and materials science.
In the field of medicinal chemistry, it is often the backbone of organic synthesis. With its unique structure, it can be cleverly connected with many active groups, just like the cornerstone of an exquisite pavilion, helping to create novel drug molecules. The Cain boron heterocyclopentane structure can participate in a variety of chemical reactions, such as the Suzuki-Miyaura coupling reaction. With this reaction, complex molecular frameworks can be precisely constructed, opening up avenues for the development of new drugs for the treatment of various diseases, such as anti-cancer and antiviral drugs.
In the field of materials science, it has also emerged. It can be introduced into polymer systems through specific reactions to give materials special photoelectric properties. For example, it may improve the luminous efficiency and stability of organic Light Emitting Diode (OLED) materials, just like injecting vitality into luminescent materials, making display devices more efficient and brighter. Or in the field of sensor materials, by virtue of its specific interaction with specific substances, to achieve highly sensitive detection of the target, just like a keen detector, accurately detect the clues of specific substances in the environment.
In summary, 2-methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxyboron heterocyclopentane-2-yl) pyridine has significant application potential in many frontier fields, promoting the continuous progress of science and technology.
What is the market price of 2-methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine
2-methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine, which is a commonly used reagent in organic synthesis, is widely used in many fields such as medicine and pesticides. Its market price is difficult to determine, due to multiple factors.
The first one to bear the brunt is the state of market supply and demand. If many pharmaceutical companies or scientific research institutions have a strong demand for it, and the supply is relatively scarce, the price will rise; on the contrary, if the demand is low and the supply is abundant, the price may decline.
Furthermore, the different manufacturers will also cause the price to vary. Different manufacturers have different production processes and cost control. Manufacturers with advanced technology and effective cost control may have competitive product prices; those with backward technology and higher costs may have higher prices.
In addition, fluctuations in raw material prices also have a significant impact. If the price of raw materials required to synthesize this compound increases, the production cost increases, and the product price will also increase; if the price of raw materials decreases, the product price may also decrease.
From this perspective, if you want to know the market price of 2-methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine, you can obtain more accurate price information by paying attention to market dynamics in real time, consulting various suppliers in detail, and comprehensively comparing their prices, quality and services.
What are the storage conditions for 2-methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridine?
2-Methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxoborocyclopentane-2-yl) pyridine, which needs to be properly stored. Due to its nature, it should be stored away from moisture and heat and placed in a cool place.
Cover the parts of its chemical structure containing boron heterocyclopentane, etc., and it is easy to react with water vapor in case of moisture, causing structural changes and affecting its quality. Heat can also promote its chemical changes and damage its original characteristics. Therefore, in a cool place, the temperature is constant, and there is less heat disturbance.
When stored, it should be stored in a sealed device to prevent external moisture and air. Glass or special plastic containers are preferred because of their stable chemical properties and do not react with the stored materials.
It should also be noted that the storage place should be kept away from sources of ignition and oxidants. Although this substance is not flammable and fried, it may get along with chemicals or cause accidents. Oxidants have strong oxidizing properties, and they may react violently with them.
In short, 2-methoxy-4- (4,4,5,5-tetramethyl-1,3,2-dioxboron heterocyclopentane-2-yl) pyridine should be kept away from moisture, heat, sealing and away from sources of ignition and oxidants to maintain its stability for later use.