2-Methoxy-3-Nitro-5-Bromopyridine

The main use of 2-% methoxy-3-furyl-5-pyridyl is as an intermediate in organic synthesis and also has important applications in the field of medicinal chemistry.
In the field of organic synthesis, this compound can act as a key building unit due to its unique chemical structure. The combination of methoxy, furyl and pyridyl gives it specific reactivity and selectivity. For example, methoxy can interact with many nucleophiles through nucleophilic substitution reactions, thereby introducing different functional groups to achieve molecular structure expansion and modification. Furyl and pyridyl groups can also participate in various cyclization reactions, coupling reactions, etc., thereby constructing more complex organic molecular frameworks.
In the field of medicinal chemistry, such structures often exhibit unique biological activities. The presence of pyridyl and furan groups may enhance the interaction between compounds and biological targets, such as binding to specific enzymes and receptors, and then exhibit potential pharmacological activities. Researchers often design and synthesize new drug lead compounds based on 2% methoxy-3-furan-5-pyridyl groups through structural optimization and modification. It may be developed into drugs with antibacterial, anti-inflammatory, anti-tumor and other effects, contributing to the development of human health. Therefore, 2-% methoxy-3-furyl-5-pyridyl plays an indispensable role in organic synthesis and pharmaceutical research and development.

To prepare 2-methoxy-3-furyl-5-bromopyridine, the following ancient methods can be used.
First, it starts with halopyridine and is obtained by multi-step conversion. First, the halopyridine is reacted with the reagent with methoxy and furyl groups under specific conditions. If a suitable base is used as the medium, in an organic solvent, heat at controlled temperature. The base can be selected from potassium carbonate, sodium carbonate and the like, and the organic solvent can be selected from N, N-dimethylformamide (DMF), dimethylsulfoxide (DMSO), etc. This step aims to introduce methoxy and furan groups. After the reaction is completed, the preliminary product is obtained by separation and purification methods, such as column chromatography. Then brominating reagents, such as bromine and N-bromosuccinimide (NBS), are used to bromide the preliminary product under suitable conditions. If NBS is used, it can be reacted in solvents such as carbon tetrachloride in the presence of initiators. Initiators such as azodiisobutyronitrile (AIBN) are reacted at temperature, and then separated and purified to obtain the target product.
Second, starting from furan derivatives. First, the furan derivative is suitably modified to introduce specific substituents to facilitate subsequent connection with the pyridine system. If the furan derivative is reacted with halogenated hydrocarbons and basic reagents, a methoxy group is introduced. Then construct the pyridine ring in a suitable method. Multi-step condensation and cyclization reactions can be used. For example, furan derivatives containing specific substituents are reacted with reagents with nitrogen sources and other necessary functional groups under the catalysis of acids or bases to form a pyridine ring skeleton. During the process, the reaction conditions need to be finely regulated, including temperature, ratio of reactants, etc. After the construction of the pyridine ring is completed, the bromination step is carried out again, which is similar to the above bromination method, so as to obtain 2-methoxy-3-furyl-5-bromopyridine. The products after each step of the reaction need to be separated and purified to maintain purity and meet the needs of subsequent reactions or use.

2-% methoxy-3-furyl-5-bromopyridine is an organic compound with specific physical properties. It is a crystalline solid, solid at room temperature and pressure, and has good stability. It is not easy to decompose under conventional conditions. However, it encounters specific chemical substances such as strong oxidants, strong acids, and strong bases, or changes its structure due to chemical reactions.
The melting point of this compound is between [specific numerical range] ° C. This property is of great significance for its separation, purification and identification. The purity of the substance can be judged by the melting point determination. If the measured melting point is consistent with the literature value and the melting range is narrow, it indicates high purity; conversely, if the melting range is wide and deviates from the literature value, it indicates impurity.
Its boiling point is in the [specific numerical range] ℃, which is very important in separation operations such as distillation. According to the difference in boiling point, the effective separation of this compound from other substances with different boiling points can be achieved.
2-% methoxy-3-furyl-5-bromopyridine is insoluble in water, because water is a solvent with strong polarity. Although there are polar groups in the structure of this compound, the overall polarity is relatively weak. According to the principle of "similar miscibility", it is insoluble in water. However, it is soluble in common organic solvents, such as dichloromethane, chloroform, acetone, etc. This solubility provides convenience for its application in organic synthesis reactions. It can choose a suitable organic solvent as the reaction medium to make the reaction proceed smoothly.
In addition, the compound is volatile to a certain extent. In a poorly ventilated environment, it may evaporate into the air. When operating, it needs to be carried out in a well-ventilated environment or in a fume hood for safety. At the same time, it is sensitive to light and heat. Under long-term light or high temperature conditions, it may decompose. Store in a cool, dry and dark place to ensure its stability.

Today there are 2-methyl-3-hydroxy-5-carboxypyridine, what is the price of its market? This is related to the price of the thing, and it is necessary to observe all the reasons in detail.
The state of the city, the price of the price is often tied to supply and demand. If there are many applicants for this thing, but there are few suppliers, the price will be high; if the supply exceeds the demand, the price will be low. And the production of this thing is also the main reason. If it is easy to produce, more will be offered, and the price will be easy; if it is difficult to produce, it will be difficult to achieve its quantity, and the price will be expensive.
It is also about its quality. Those who are of high quality, everyone wants to get it, and the price may be high; those who are of inferior quality, although they are cheap, people may not take it. And the method of making this thing is also related to the price. The ancient method may be time-consuming and labor-intensive, resulting in its high cost, and the price will also rise accordingly; if there is a new law, it is convenient and cost-saving, and the price will also drop.
Furthermore, the price varies from time to place. At that time and place, or depending on the situation, the price will rise and fall. In prosperous places, those who ask for more or more, the price may increase; in remote places, those who ask are scarce, and the price may decrease. When it is urgently needed, the price is always high; when it is soothing, the price may be flat.
Overall, in order to know the market price of 2-methyl-3-hydroxy-5-carboxypyridine, it is necessary to clarify the status of supply and demand, the difficulty of production, the quality of quality, and the differences in the method of preparation. However, without knowing all the details, it is difficult to determine its exact market price.

In storage and transportation of 2-% methoxy-3-furyl-5-bromopyridine, the following key points should be paid attention to.
For storage, one should choose a cool, dry and well-ventilated place. This is because the substance may be sensitive to humidity and temperature, and humid environments are prone to deliquescence and other conditions. Excessive temperature may also cause chemical reactions and cause the substance to deteriorate. Second, it needs to be strictly separated from oxidants, acids, bases, etc. The chemical properties of 2-% methoxy-3-furyl-5-bromopyridine make it very likely to trigger violent chemical reactions when it comes into contact with these substances, such as oxidation and reduction reactions, acid-base neutralization, etc., which will not only destroy the structure and properties of the substance itself, but may even cause serious accidents such as fires and explosions. Third, the storage area must be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. In the event of an unexpected situation, such as fire or leakage, response measures can be taken quickly to reduce losses and hazards.
In terms of transportation, first of all, the packaging must be complete and sealed before transportation. Only in this way can we avoid the leakage of materials due to damaged packaging during transportation, which will cause harm to the environment and transportation personnel. Secondly, during transportation, it is necessary to ensure that the container does not leak, collapse, fall, or be damaged. It is necessary to know that bumps, vibrations, etc. will inevitably be encountered during transportation. If there is a problem with the container, it is easy to cause serious consequences. Furthermore, the vehicles used during transportation should be equipped with corresponding fire-fighting equipment. In view of the possible danger of the substance, once an emergency such as a fire occurs during transportation, it can be put out in time. Moreover, the transportation vehicles also need to follow the prescribed route and do not stay in densely populated areas and residential areas for a long time. In this way, the possibility of harming a large number of people in the event of an accident can be effectively reduced.