2-Methoxy-3-Bromo-5-Chloropyridine

The main use of 2-% ethyloxy-3-carbonyl-5-bromide is its important value in many fields.
In the field of pharmaceutical synthesis, this compound can be used as a key intermediate. Its structural properties enable it to participate in a variety of chemical reactions to construct molecular structures with specific pharmacological activities. For example, it can be combined with other active groups through a series of organic synthesis steps to create new antimicrobial drugs. By chemically modifying it, the lipophilicity, water solubility and interaction with biological targets of the drug can be regulated, thereby enhancing the efficacy and safety of the drug.
In the field of materials science, 2-% ethyloxy-3-carbonyl-5-bromine also plays an important role. Due to its specific electron cloud distribution and chemical activity, it can be used to prepare functional polymer materials. For example, introducing it into the polymer main chain or side chain can endow the material with unique optical, electrical or thermal properties. Or in the preparation of optoelectronic materials, this compound can be used as a photosensitive unit to improve the material's response to specific wavelengths of light, so that it can be used in optoelectronic devices, such as organic Light Emitting Diode (OLED), solar cells, etc., to enhance the performance of the device.
It is also a very commonly used reagent in laboratory research in organic synthetic chemistry. Chemists use the synergy effect of its active bromine atom with carbonyl and ethoxy groups to carry out various classical organic reactions, such as nucleophilic substitution reactions and addition reactions. Through ingenious design of reaction paths, organic compounds with complex structures and special uses can be synthesized with it as a starting material, providing a rich material basis and research ideas for the development of organic synthetic chemistry.

To prepare 2-methoxy-3-bromo-5-fluorobenzene, the method is as follows:
First, the phenol can be started with a suitable phenolic compound. First, the phenol is reacted with the halomethane under alkaline conditions to introduce a methoxy group. The base can be selected from potassium carbonate or the like. In a suitable organic solvent such as N, N-dimethylformamide (DMF), heating and stirring, the hydroxyl group of the phenol will undergo a nucleophilic substitution reaction with the halomethane to obtain a methoxy-containing intermediate.
Subsequently, the intermediate is brominated. Using liquid bromine as the bromine source, bromine atoms can be introduced at specific positions in the benzene ring in the presence of suitable catalysts such as iron powder or iron tribromide, and in suitable solvents such as dichloromethane. Because the substituents on the phenol derivatives benzene ring affect the regioselectivity of bromination, a product containing methoxy groups and bromine atoms can be obtained through this step.
Finally, the product is fluorinated. Commonly used fluorinating reagents such as potassium fluoride, in the presence of a phase transfer catalyst such as tetrabutylammonium bromide, in a high-boiling polar solvent such as dimethyl sulfoxide (DMSO), heating the reaction can replace the halogen atom at a suitable position on the benzene ring with a fluorine atom, and then obtain the target product 2-methoxy-3-bromo-5-fluorobenzene.
Second, it can also start from halobenzene. First, the fluorine atom is introduced by reacting with the halobenzene with a suitable nucleophilic reagent, and the reaction conditions are controlled to position the fluorine atom at a suitable position. After that, the bromination reaction is carried out. Similar to the previous, the bromine atom is introduced at a specific position in the Finally, by reacting with halogenated methane and alkali, methoxy groups are introduced to achieve the purpose of preparing the target product. During the reaction process, it is necessary to carefully control the reaction conditions of each step, such as temperature, ratio of reactants, reaction time, etc., to improve the yield and product purity.

I think what you are asking is about "the market price of 2-methoxy-3-hydroxy-5-iodine". However, this is not a field I am familiar with, and it is difficult to find such accurate price records in ancient books.
In today's world, the price of a product often varies greatly depending on time, place, and supply and demand. To know the exact market value of this product, you need to look at various factors. First, the difference in origin has a great influence. If the production is easy and the source is wide, the price may be stable and flat; if the production is difficult, the place is remote, and the transportation is difficult, the price will increase.
Second, the trend of supply and demand is also the key. If there are many people seeking, but there are few suppliers, the so-called "rare things are expensive", the price will rise; if the supply exceeds the demand, in order to sell the goods, the price may drop.
Third, the level of craftsmanship is also related to the price. If the process of preparing this thing is refined, labor-intensive, and high-cost, the price is not cheap; if the process is simple and the cost is low, the price may be close to the people.
In my opinion, if you want to know its market value, you can visit various merchants and experts, or check the records of the city and the reports of merchants, so that you can get a relatively accurate number. However, at the price of this item, it is difficult to determine the specific value. I hope you can follow this line of thinking and find the required price in the current market information.

The physicochemical properties of 2-% methoxy-3-bromo-5-fluorobenzene are as follows:
Its external properties are often solid or liquid, depending on the environment. As far as melting is concerned, because the molecules of the compound contain different groups, the interaction of the groups makes the melting fall in a certain area, and then the melting needs to be refined.
The boiling force of this substance is also closely related to the molecular force. The presence of bromine, fluorine and other elements in the molecule increases the molecular force, resulting in a high boiling phase.
In terms of solubility, because the methoxy group has a certain water content, and the presence of bromine, fluorine atoms and benzene atoms makes the molecule have a certain hydrophobicity, so its solubility in water is limited, and it has good solubility in solvents such as dichloromethane and chloroform. The chemical properties of
compounds show a specific inverse activity due to the substituents on benzene. Methoxy groups supply a daughter group, which can increase the density of the daughter of benzene and increase the inverse activity of benzene. Bromine atoms and fluorine atoms can be nuclear-substituted and reversed under certain conditions, especially under appropriate catalytic and inverse conditions, fluorine atoms can be implanted by other nuclei. In addition, compounds can also be added to some benzene-based compounds, etc., which have the opposite effect of the reaction to the reaction environment and the reaction to the reaction.

When storing and transporting 2-% methoxy-3-bromo-5-fluoropyridine, it is necessary to pay attention to many key matters.
First package. It must be sealed in a tight and suitable container to prevent material leakage. Because the substance may have a certain chemical activity, if it leaks or reacts with surrounding substances, it will cause danger. For example, it should be packed in a special glass container, tightly sealed, and then wrapped with protective materials to avoid shock damage during handling.
Second environment. Storage should be in a cool, dry and well-ventilated place. High temperature or cause substances to evaporate faster, or even cause chemical reactions; humid environment may cause substances to deteriorate under moisture. If the warehouse temperature should be controlled within a certain range, the humidity should also be maintained at a low level.
When transporting, follow specific regulations and standards. Transport personnel must be professionally trained and familiar with the characteristics of the substance and emergency treatment methods. And the means of transportation should also be protected and marked accordingly, such as warning labels, indicating the danger of the substance, so that relevant personnel can be alerted.
Furthermore, avoid contact with incompatible substances. 2-% methoxy-3-bromo-5-fluoropyridine or reacts violently with certain oxidizing agents, reducing agents, etc., so it must not be mixed with such substances during storage and transportation to prevent accidents.
Keep records. Detailed records of the storage location, warehousing time, transportation route, etc. of the substance for traceability and management. If there is an accident, it can also be recorded that prompt response measures can be taken.
In short, 2-% methoxy-3-bromo-5-fluoropyridine should not be ignored in all aspects of storage and transportation. It needs to be strictly operated according to specifications to ensure its safety and stability.