2-Methoxy-3-aminopyridine

2-% methoxy-3-hydroxypyridine is a crucial raw material in organic synthesis and has a wide range of uses in many fields.
In the field of medicinal chemistry, it is often used to prepare various drugs. Due to its specific chemical structure, it can be combined with specific targets in organisms and exhibit unique pharmacological activities. For example, it can be used to develop antibacterial drugs, which can inhibit the growth and reproduction of bacteria by virtue of their structural compatibility with key metabolic enzymes in bacteria; or it can be used to create nervous system drugs, regulate the transmission of neurotransmitters, and improve the symptoms of related nervous system diseases.
In the field of materials science, 2-% methoxy-3-hydroxypyridine can be used as an important monomer in the synthesis of functional materials. Through polymerization and other means, it can be introduced into the structure of polymer materials, giving the material special properties. For example, synthesizing materials with specific optical properties for use in optical sensors and other fields, the special structure can respond to specific wavelengths of light to achieve the detection of specific substances; or preparing materials with good electrical conductivity for use in electronic devices.
In agricultural chemistry, this compound can be used to develop new pesticides. It can have a specific mechanism of action against pests or pathogens by virtue of its own structural properties. For example, interfering with the nervous system of pests, causing their behavior to be disordered, and then achieving the purpose of controlling pests; or inhibiting some key metabolic processes of pathogens, preventing the growth and spread of pathogens, and providing protection for the healthy growth of crops.
In summary, 2-% methoxy-3-hydroxypyridine, with its unique chemical structure, plays an indispensable role in many fields such as medicine, materials, and agriculture, and has greatly promoted the development and progress of related fields.

2-% methoxy-3-hydroxybenzaldehyde, the physical properties are as follows:
In terms of solubility, it is a light yellow to off-white crystalline powder, exposed to sunlight for a long time, and the color gradually changes. Under room temperature, the texture is dry, and the hand touches it, delicate without agglomeration.
Smell it, it has a weak special aroma, non-rich and strong smell, but it can be distinguished by a small smell. Its unique smell is not pungent, and it is still pleasant.
In terms of solubility, it is slightly soluble in water. Water is the source of life, and everything is soluble in it. However, this compound is only slightly soluble, and it is mostly suspended and dispersed in water. It dissolves well in organic solvents such as ethanol, ether, and chloroform. Ethanol, a common organic solvent, is mixed with 2-% methoxy-3-hydroxybenzaldehyde, which can rapidly dissolve into a uniform and transparent solution.
The melting point is between 82 ° C and 85 ° C. When the temperature rises gradually, it slowly melts from solid to liquid. This process is not done overnight, but goes through a gradual change from solid to semi-solid and then to liquid. The characteristics of the melting point are crucial in the identification and purification of this compound.
The boiling point is around 304.9 ° C. When the temperature approaches this value, the compound molecules gain a sharp increase in energy, break free from each other, and escape from liquid to gas.
Its stability also needs attention. In a dry environment at room temperature and pressure, it is relatively stable and can last for a long time without deterioration. When exposed to strong acids, strong alkalis, or high temperatures and high humidity, it is easy to cause chemical reactions, and the structure is damaged, causing it to lose its original characteristics and efficacy.
The physical properties of 2-% methoxy-3-hydroxybenzaldehyde are various. They are used in many fields such as chemical industry and medicine. They are all key reference bases to help craftsmen, doctors, etc. make good use of this material and make products that benefit the people.

The chemical properties of 2-% methoxy-3-hydroxybenzaldehyde are relatively stable. The reason is that the structure of the benzene ring gives it high stability. The benzene ring is a conjugated system, and the electron cloud is uniformly distributed over the entire ring, forming a delocalized π bond, which reduces the energy of the system and increases the molecular stability.
In 2-% methoxy-3-hydroxybenzaldehyde, the methoxy group and the hydroxyl group are used as electron donor groups to provide electrons to the benzene ring through the conjugation effect, which enhances the electron cloud density of the benzene ring. This electron cloud density change will affect the electrophilic substitution reaction activity on the benzene ring, but it is beneficial to the overall stability of the molecule. The oxygen atom of the methoxy group has a lone pair of electrons, which can be conjugated with the benzene ring, so that the electron delocalization range is wider and the system is more stable.
Although the aldehyde group has certain reactivity, it can participate in many reactions under specific conditions, such as oxidation reactions and nucleophilic addition reactions. However, in general environments, as long as there are no specific reagents or conditions to initiate the reaction, the aldehyde group is relatively stable. In addition, there may be hydrogen bonding in the molecule of 2-% methoxy-3-hydroxybenzaldehyde. Hydroxy hydrogen atoms can form intramolecular hydrogen bonds with neighboring atoms, such as aldehyde oxygen atoms, which play an important role in stabilizing the molecular structure and enhancing its chemical stability.
However, it should be noted that although the chemical properties of this substance are relatively stable, it is not absolute. Under the conditions of high temperature, strong acid base or the presence of a specific catalyst, its structure and properties will change. For example, under the action of strong oxidants, aldehyde groups may be oxidized to carboxyl groups; in strong acid or alkali environments, methoxy, hydroxyl and other groups may participate in the reaction, resulting in molecular structure changes.

To prepare 2-methyl-3-nitropyridine, there are three methods.
One is to start with pyridine, through alkylation, introduce methyl-based binary position, and then nitrate, so that the nitro group enters three digits. In this way, the first alkylation, the electron cloud density of the pyridine ring changes, the regional selectivity of the nitrification reaction is difficult to control, there are many by-products, separation is troublesome, and the yield is not high.
The second is to use 2-methyl pyridine as the raw material and nitrate it. Because methyl is an ortho-para-localization group, although there are also three-position products, there are many ortho-position products. To obtain high-purity 2-methyl-3-nitropyridine, complicated separation is required, and the nitrification conditions are harsh and the operation is not easy.
The third is to construct a pyridine ring through multi-step reaction. For example, a suitable nitrogen-containing compound and a compound containing carbonyl and alkenyl groups are used through a series of reactions such as condensation and cyclization to obtain a pyridine ring. In the process, it is cleverly designed so that methyl and nitro occupy two and three positions respectively. Although there are many steps in this way, the position of the substituent can be precisely controlled. The product has high purity and the yield can be observed. The only route is long, and the reaction conditions and operation requirements are very strict.
The above methods have their own advantages and disadvantages. In actual preparation, when considering factors such as the availability of raw materials, cost, and product purity requirements, the appropriate method should be selected.

Today there are 2-methyl-3-hydroxypyridine, want to know its price range in the market. The price of the goods often varies for many reasons. If this 2-methyl-3-hydroxypyridine is for ordinary industrial use and the output is quite large, its price may be relatively easy. In the case of block trade, the price per kilogram may be in the range of hundreds of dollars.
However, if its purity requirements are extremely high, such as for special purposes such as pharmaceutical research and development, high-end chemical experiments, etc., because its preparation requires fine technology and strict procedures, the cost will increase greatly, and its price will also rise. At this time, the price per gram may reach several dollars or even tens of dollars.
Furthermore, the state of market supply and demand also affects its price. If there are many people who want it, but there are few products, the price will tend to rise; if the product is too much, the price may be downward. And in different regions, due to differences in transportation costs and taxes, the price is also different. In prosperous cities, the logistics is convenient, or due to fierce competition, the price may be slightly flat; in remote places, due to difficult transportation, the price may be slightly higher.
In addition, the quality of products produced by different manufacturers is different, and the price is also different. Well-known large factories, focusing on quality control, product purity is good, quality is stable, and its price may be higher than that of other factories; and small factories, or due to the process is slightly less, the price may be slightly lower. Therefore, the price range of 2-methyl-3-hydroxypyridine on the market ranges from roughly a few dollars per gram to several hundred dollars per kilogram, which needs to be studied carefully according to the specific situation.