2-MERCAPTO-3-PYRIDINECARBOXYLIC ACID

2-Mercapto-3-pyridinecarboxylic acid is a special chemical substance with a wide range of uses.
In the field of medicine, its role is crucial. Because of its unique chemical structure, it can participate in a variety of drug synthesis reactions. Taking some antibacterial drugs as an example, 2-mercapto-3-pyridinecarboxylic acid can act as a key intermediate to help drugs build a specific molecular structure and enhance the drug's ability to inhibit and kill bacteria. Furthermore, in the development of some drugs for the treatment of cardiovascular diseases, it can optimize the combination of drugs and targets by adjusting the distribution of electronic clouds of drug molecules to improve drug efficacy.
In the field of materials science, 2-mercapto-3-pyridinecarboxylic acid also has outstanding performance. In the preparation of some functional polymer materials, it is introduced into the polymer chain segment, which can endow the material with special properties. For example, the preparation of materials with high selective adsorption of specific metal ions, the mercapto-group and pyridine ring structure of 2-mercapto-3-pyridinecarboxylic acid can complexate with metal ions, so that the material exhibits excellent adsorption properties for specific metal ions, and has potential application value in the removal of heavy metal ions in wastewater treatment.
In addition, in the field of chemical analysis, it can be used as an excellent analytical reagent. Qualitative and quantitative analysis of metal ions can be achieved by taking advantage of its characteristic of forming specific color complexes with some metal ions. For example, when detecting the concentration of copper ions in solution, the complex formed by the reaction of 2-mercapto-3-pyridinecarboxylic acid has a unique absorption spectrum, which can be used to accurately determine the content of copper ions.
In summary, 2-mercapto-3-pyridinecarboxylic acid plays an indispensable role in many fields such as medicine, materials science, chemical analysis, etc., providing important material basis and technical support for the development of related fields.

2-Mercapto-3-pyridinecarboxylic acid is an organic compound. Its physical properties are quite important and are related to many chemical applications.
Looking at its properties, under normal temperature and pressure, 2-mercapto-3-pyridinecarboxylic acid is often in a solid state. This solid state is easy to store and transport. And its color is mostly white to light yellow powder, which can help distinguish.
When it comes to melting point, this compound has a high melting point, about 210-215 ° C. The characteristics of melting point are of great significance in material identification and purity judgment. If the melting point is accurate and the melting range is narrow, it can be proved that its purity is quite good.
Solubility is also a key physical property. The solubility of 2-mercapto-3-pyridinecarboxylic acid in water is limited, but it has good solubility in some organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), etc. This difference in solubility has a significant impact on chemical synthesis and separation and purification steps. In organic synthesis, the choice of a suitable solvent can promote the reaction; in separation and purification, impurities can be effectively removed according to the difference in solubility.
In addition, the density of 2-mercapto-3-pyridinecarboxylic acid also has a certain value. Although it is not widely known, density data is indispensable for accurate stoichiometry and reaction system design. Knowing the density can accurately measure the substance and ensure that the reaction proceeds as expected.
Furthermore, its smell is weak, not pungent and unpleasant. This odor characteristic, in experimental operation and practical application scenarios, can make the working environment more comfortable and reduce the olfactory stimulation to experimenters and users.
In summary, the physical properties of 2-mercapto-3-pyridinecarboxylic acid, such as solid form, color, melting point, solubility, density, and odor, are interrelated and affect its application in the chemical field. It is of great value in synthesis, analysis, and practical use.

2-Mercapto-3-pyridinecarboxylic acid is a unique organic compound. It is acidic, and the carboxyl group in the cover molecule can release protons. In suitable solvents, it can exhibit the characteristics of acids and neutralize with bases to generate corresponding salts and water.
In terms of its chemical activity, the mercapto group is extremely active. The sulfur atom in this group contains lone pairs of electrons, making it easy to react with electrophilic reagents. For example, it can react with halogenated hydrocarbons and form new sulfur-containing organic compounds through nucleophilic substitution processes. It is often used as a key intermediate in the field of organic synthesis to build complex molecular structures.
At the same time, the pyridine ring endows the compound with certain aromaticity and stability. The nitrogen atom of the pyridine ring is weakly basic and can bind to protons to participate in acid-base equilibrium-related reactions under specific conditions. In addition, the pyridine ring can participate in a variety of electrophilic substitution reactions. Due to the uneven distribution of electron clouds on the pyridine ring, specific positions have different activities for electrophilic reagents. By regulating the reaction conditions, the substitution of specific positions can be realized, providing the possibility for the synthesis of various derivatives.
Furthermore, the carboxyl groups and thiol groups in the molecule of 2-mercapto-3-pyridinecarboxylic acid can form intramolecular or intermolecular hydrogen bonds. This hydrogen bonding has a significant impact on its physical properties, such as melting point, boiling point, solubility, etc. Intermolecular hydrogen bonding may increase the melting point and boiling point of the compound, while intramolecular hydrogen bonding may affect its solubility and crystal structure in different solvents. In short, the unique chemical properties of the compound make it potentially useful in many fields such as organic synthesis and medicinal chemistry.

The synthesis method of 2-mercapto-3-pyridinecarboxylic acid has been explored by many families in the past, and the methods are also numerous.
First, it is modified with pyridine as a group through multiple steps. The carboxyl group is introduced into the pyridine at a specific position before the specific position of the pyridine. In this step, suitable carboxylating reagents, such as carbon dioxide and a strong base, can be used in synergy to carboxylate the pyridine ring at a suitable temperature and pressure. Then, the thiol group is introduced at the ortho position. The target product can be obtained by means of a halogenation reaction, first halogenating the pyridine ring with a halogenating agent, and then nucleophilic substitution reaction with thiol-containing reagents, such as sodium hydride. < Br >
Second, starting from a specific pyridine derivative. If there are some substituents on the pyridine ring, such as some groups that are easy to convert into carboxyl and thiol groups. First modify one of them to a carboxyl group, such as by hydrolysis, oxidation, etc., depending on the characteristics of the original substituent. Then through a specific reaction, the other group is converted to a thiol group, or directly introduced into a thiol group. This path or reduced step requires a specific starting material, which requires higher requirements for the acquisition of raw materials and preliminary synthesis.
Third, the reaction is catalyzed by transition metals. Use suitable transition metal catalysts, such as palladium, copper, etc. to catalyze the coupling reaction between the substrate containing the pyridine structure and the reagent containing the carboxyl group and the thiol group. This method has good selectivity and relatively mild conditions. However, the choice of catalyst and the precise regulation of reaction conditions are crucial. Factors such as catalyst activity, ligand selection, reaction solvent, and alkali need to be considered in order to achieve the purpose of efficient synthesis.
This method has its own advantages and disadvantages. In practical applications, it should be selected according to factors such as the availability of raw materials, the difficulty of reaction, cost, and yield.

In the market, the price of 2-mercapto-3-pyridinecarboxylic acid varies depending on the purity and quantity of the product. In ordinary trade, if its quality and purity are small, it is used for experimental research, and the price per gram may be between tens of gold and hundreds of gold. If it is purchased in bulk and used in various industrial processes, the price will decrease slightly due to the increase in quantity, and the price per kilogram may be in the range of thousands of gold.
However, its price also varies with the supply and demand of the market and the difficulty of production. If the raw materials produced are rare, or the production process is complicated, the price will increase. And if there are many people in need, and there are few suppliers, the price will also increase. On the contrary, the raw materials are abundant, the process is simple, and the supply exceeds demand, so the price may drop.
The range of market prices ranges from tens of gold per gram to thousands of gold per kilogram. Buyers should carefully observe the market conditions and compare the prices of various companies before they can get the appropriate price.