2-iodo-5-aminopyridine

2-Iodine-5-aminopyridine has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the creation of various specific drugs. The special structure of the geinopyridine ring and the unique chemical properties of iodine and amino groups enable it to participate in a variety of chemical reactions and realize the construction of complex drug molecules. For example, in the synthesis of some antibacterial drugs, 2-iodine-5-aminopyridine can react with specific reagents and undergo multiple steps of delicate transformation to generate compounds with antibacterial activity, which is of great significance for the treatment of related diseases.
In the field of materials science, it also has important applications. It can be used as the cornerstone of building functional materials. By ingeniously combining with other organic or inorganic components, the materials are endowed with novel electrical and optical properties. For example, in the preparation of some optoelectronic materials, 2-iodine-5-aminopyridine participates in the reaction to form a special structure, which can optimize the charge transport performance of the material and improve its performance in optoelectronic devices. The performance improvement of devices such as organic Light Emitting Diode is closely related to it.
In organic synthetic chemistry, 2-iodine-5-aminopyridine is an important raw material commonly used. With the high reactivity of iodine atoms and the orientation of amino groups, chemists can diversify and modify them through classical organic reactions such as halogenation and coupling reactions to synthesize organic compounds with complex structures and unique functions, providing many possibilities for the development of organic synthetic chemistry.

The common methods for synthesizing 2-iodine-5-aminopyridine are as follows.
First, 5-aminopyridine is used as the starting material and iodine atoms are introduced through halogenation reaction. Suitable halogenating reagents, such as N-iodosuccinimide (NIS), can be selected. In a suitable solvent, such as dichloromethane, under mild reaction conditions, such as room temperature, and with a suitable catalyst, the reaction can proceed smoothly. This method is relatively simple, and the amino group of 5-aminopyridine can be properly protected to prevent it from being affected during halogenation. After the reaction is completed, the protective group is removed to obtain the target product.
Second, using pyridine as the starting material, the amino group is first introduced into the pyridine ring. Nitro can be introduced into the appropriate position of the pyridine ring through nitration reaction, and then reduced to convert the nitro group into an amino group. Then a halogenation reaction is carried out to introduce iodine atoms. For example, nitrification is carried out in a mixed acid system of nitric acid and sulfuric acid, and the reaction conditions are controlled so that the nitro group mainly enters the fifth position of the pyridine ring. After reducing the nitro group to the amino group by iron powder or hydrogenation, the iodine substitution reaction is carried out with halogenating reagents such as NIS. Although this route has a little more steps, the raw material pyridine has a wide range of sources and the cost is relatively low.
Third, the coupling reaction catalyzed by transition metals For example, with 2-halogenated pyridine (such as 2-chloropyridine) and an iodine substitution reagent, a halogen atom exchange reaction occurs under the action of a transition metal catalyst such as a palladium catalyst, and an iodine atom is introduced. At the same time, an amino group is introduced at the 5th position of the pyridine ring through a suitable amination reagent. This method requires harsh reaction conditions and requires precise control of catalyst dosage, reaction temperature and time. However, its high selectivity can effectively reduce the occurrence of side reactions, which is conducive to improving product purity and yield.

2-Iodo-5-aminopyridine, or 2-iodo-5-aminopyridine, is an important compound in the field of organic chemistry. Its physical properties are crucial and are closely related to many chemical processes and practical applications.
First of all, 2-iodo-5-aminopyridine usually appears in a solid state, which is convenient for storage and transportation. In a specific reaction system, the solid state helps to precisely control the reaction dose and reaction process. Furthermore, the melting point is also an important physical parameter. Although no exact data are available, most of these compounds containing nitrogen heterocycles and halogen atoms have a melting point within a certain range. The melting point characteristics determine their physical state transition under different temperature conditions, which has a great impact on the reaction operation during heating or cooling.
In terms of solubility, the dissolution of 2-iodine-5-aminopyridine in organic solvents is worthy of attention. Generally speaking, it should have a certain solubility in common organic solvents such as ethanol and dichloromethane. In ethanol, with the help of intermolecular hydrogen bonding and similar miscibility principles, a certain degree of dissolution can be achieved. This dissolution property provides the possibility for chemical reactions using ethanol as a solvent. In dichloromethane, due to the polarity of dichloromethane and the structure of halogenated hydrocarbons, it interacts with 2-iodine-5-aminopyridine to dissolve it, which is of great significance in organic synthesis for extraction, separation or as a reaction medium.
In addition, the density of 2-iodine-5-aminopyridine also has research value. Although the specific value is not detailed, it is inferred from the structure that the density of iodine atoms should be higher than that of general pyridine compounds due to the large relative atomic mass of iodine atoms. Density affects its phase distribution in the mixed system. When it involves delamination, centrifugation and other operations, density parameters play an indispensable role in the effective separation of the compound.
As for its volatility, given that it is a solid and the intermolecular force is relatively strong, the volatility should be low. This property makes it difficult to evaporate into the air under conventional conditions, which is conducive to maintaining the stability of the reaction system and the safety of the operator. In conclusion, the physical properties of 2-iodine-5-aminopyridine have far-reaching significance for its application in organic synthesis, drug development and other fields. In-depth understanding of these properties will help to better control the chemical processes related to it.

2-Iodine-5-aminopyridine is one of the organic compounds. It has many unique chemical properties, which are described as follows:
- ** Nucleophilic Substitution Reactivity **: In its structure, the iodine atom is a good leaving group. Therefore, 2-iodine-5-aminopyridine is easily attacked by nucleophiles and triggers nucleophilic substitution reactions. For example, when there are reagents containing nucleophilic groups such as hydroxyl and amino groups, the iodine atom can be replaced by these nucleophilic groups to form new compounds. This property makes it commonly used in the field of organic synthesis to construct various complex molecular structures containing nitrogen and oxygen. < Br > - ** Basic **: The amino group in the molecule gives it a certain alkalinity. In a suitable pH environment, the amino group can accept protons and generate corresponding salts. This basic property not only affects its solubility in solution, but also plays a key role in some acid-base catalyzed chemical reactions, and can participate in the regulation of acid-base equilibrium and catalytic reaction processes.
- ** Aromatic and electronic effects **: The compound has a pyridine ring structure and exhibits typical aromaticity. Amino groups are electron-supplying groups, which can supply electrons to the pyridine ring through conjugation effects; iodine atoms have electron-absorbing induction effects. The combined effect of these two electronic effects results in changes in the electron cloud density distribution on the pyridine ring, affecting its chemical reactivity and selectivity. For example, during electrophilic substitution reactions, the reaction check points tend to be relatively high in the electron cloud density after being affected by electronic effects.
- ** Stability **: Under normal conditions, 2-iodine-5-aminopyridine is relatively stable. However, under extreme conditions such as strong oxidizing agents, strong acids, strong bases or high temperatures, its structure may be damaged. For example, in a strong oxidizing environment, amino or iodine atoms may be oxidized, resulting in changes in molecular structure and properties. When storing and using this compound, it is necessary to fully consider its stability and choose appropriate conditions to prevent deterioration.

The price of 2-iodine-5-aminopyridine in the market varies due to many factors and is difficult to determine. One of these factors is the state of supply and demand. If there are many people and few suppliers, the price will rise; if the supply exceeds the demand, the price will drop. The second is related to the difficulty of preparation. The preparation of 2-iodine-5-aminopyridine, or involves a multi-step reaction, requires special reagents and conditions. The steps are complex, difficult, and the cost also increases, so the price is expensive. Furthermore, the price of raw materials also affects. The price of raw materials required for preparation is high, and the price of finished products is also high. And the state of market competition and the size of production scale all affect its price.
According to past market conditions, when the amount of 2-iodine-5-aminopyridine sold by chemical reagent suppliers is small, the price per gram may range from tens to hundreds of yuan, which may be due to factors such as small packaging and transportation costs. If it is an industrial-grade purchase, the quantity reaches the kilogram level. Due to the scale effect, the price per kilogram may drop to several thousand yuan. However, this is only an approximation, and the actual price must be subject to the current quotation of each supplier. For real-time prices, you can consult chemical reagent suppliers such as Sinopharm Group Chemical Reagent Co., Ltd., search banner reagent network, etc., or check and compare in detail on the chemical product trading platform.