2-(Imidazol-2-yl)pyridine

2-%28Imidazol-2-yl%29pyridine is 2- (imidazole-2-yl) pyridine, which has a wide range of uses. In the field of pharmaceutical research and development, it is a key organic synthesis intermediate and plays a significant role in the creation of new drugs. The synthesis of many bioactive compounds often uses 2- (imidazole-2-yl) pyridine as the starting material. Through various chemical reactions, drug molecules with high affinity and selectivity for specific disease targets can be obtained. The development of drugs such as anti-tumor, antiviral, and antibacterial has its own impact.
In the field of materials science, 2- (imidazole-2-yl) pyridine also has excellent performance. Due to its unique structure, it can coordinate with metal ions to form metal complexes with special optical, electrical or magnetic properties. These complexes can be used to prepare luminescent materials. In organic Light Emitting Diodes (OLEDs), they can be used as luminescent layer materials to improve the luminescent efficiency and color purity of devices. They can also be applied to the field of sensor materials, which can achieve highly sensitive detection of ions, molecules, etc. based on their specific interactions with specific substances.
In addition, in the field of catalysis, 2- (imidazole-2-yl) pyridine has shown excellent performance as a ligand. The catalyst of the complex formed with transition metals has high catalytic activity and selectivity for many organic reactions. For example, in the formation of carbon-carbon bonds and carbon-heteroatomic bonds, such catalysts can significantly reduce the reaction conditions, improve the reaction yield, and promote more green and efficient organic synthesis reactions, providing strong support for the development of organic synthesis chemistry.

To prepare 2 - (imidazole-2-yl) pyridine, there are three methods. One is the cyclization condensation method. The compound can be obtained by using 2-pyridine formaldehyde, glyoxal and ammonia as the starting materials, and in an appropriate reaction medium, through the cyclization condensation step. This reaction requires appropriate temperature and pH to obtain the ideal yield. During the reaction, the proportion of the reactants is also critical, and if the ratio is inappropriate, the yield will be poor.
The second is the metal catalytic coupling method. Using 2-halogenated pyridine and imidazole derivatives as raw materials, under the catalysis of metal catalysts such as palladium and copper, the coupling reaction occurs to obtain the target product. In this process, the choice and dosage of metal catalysts are extremely important, and different metal catalysts and dosages have a significant impact on the reaction rate and selectivity. And the appropriate ligand needs to be selected to help the catalyst play its role, and at the same time, attention should be paid to the choice of reaction solvent, which also plays a role in the reaction process.
The third is the guide group-assisted method. Introduce a guide group on the pyridine ring and make it react with imidazole derivatives. By the positioning effect of the guide group, the reaction selectively occurs at a specific position, and then remove the guide group to obtain 2 - (imidazole-2-yl) pyridine. The key to this method is the selection of guiding groups, which need to be easy to introduce and remove, and have a good guiding effect on the reaction selectivity. Throughout the process, the precise control of the reaction conditions at each step, such as temperature, time, and concentration of reactants, all affect the purity and yield of the product.

2-%28Imidazol-2-yl%29pyridine is 2- (imidazole-2-yl) pyridine, which is an organic compound. Its physical and chemical properties are very critical, and it is of great significance in chemical research and many practical application fields.
Let's talk about the physical properties first. At room temperature, 2- (imidazole-2-yl) pyridine is often in a solid form with a specific melting point and boiling point. The melting point determines the temperature at which it melts from solid to liquid, and the boiling point is related to the condition at which it changes from liquid to gaseous. Its appearance may be white to light yellow crystalline powder, which is easy to identify and distinguish in experiments and production. Furthermore, the substance has certain solubility in specific solvents. Organic solvents such as ethanol and dichloromethane may exhibit good solubility, while their solubility in water may be limited. This difference in solubility has a significant impact on their performance in different reaction systems and separation and purification steps.
As for chemical properties, in the structure of 2- (imidazole-2-yl) pyridine, the pyridine ring and the imidazole ring give it unique chemical activity. The pyridine ring is aromatic, and the presence of nitrogen atoms makes the ring electron cloud uneven, making the pyridine ring prone to electrophilic substitution at specific positions. The imidazole ring is also aromatic, and the electronic effects of the two nitrogen atoms interact with each other, making the imidazole ring part more active to electrophilic reagents. Due to its nitrogen-containing structure, it can be used as a ligand to coordinate with metal ions to form metal complexes. This property is widely used in the field of catalysis. Metal complexes may exhibit unique catalytic activity and selectivity, and can catalyze many organic reactions. At the same time, the nitrogen atom of 2- (imidazole-2-yl) pyridine can participate in acid-base reactions, reflect basicity under certain conditions, and neutralize with acids to form salt compounds.

2-%28Imidazol-2-yl%29pyridine is 2- (imidazole-2-yl) pyridine, the price of this product in the market is difficult to determine. The price often varies due to many factors, such as the quality of the good or bad, the situation of supply and demand, and the difficulty of production, and the seller is different, the price is also different.
If the quality is high, it is suitable for high-end experiments or special industrial use, and the price is not cheap. However, if it is ordinary quality, it is only for general research purposes, and the price is slightly lower. And if you buy a lot and buy a small amount, the price is also different. If you buy a lot, or because of wholesale discounts, the price will drop; if you buy a small amount, the unit price will increase due to cost sharing, etc.
And the market supply and demand situation, which has a great impact on its price. If there are many applicants, but there are few suppliers, the price will rise; if the supply exceeds the demand, the merchant will sell its goods or reduce the price. Furthermore, if the production process is complicated and the cost is high, the price in the market will also be high; if the process is simple, the cost can be controlled, and the price may be close to the people.
In order to know the exact price of 2- (imidazole-2-yl) pyridine, it is necessary to carefully consider the quality, supply and demand, purchase quantity, etc., and consult various suppliers to obtain a more accurate price. However, at present, it is difficult to give a fixed price range.

2-%28Imidazol-2-yl%29pyridine is 2 - (imidazole-2-yl) pyridine. The Quality Standard of this substance covers various factors such as purity, impurity limit, and physical properties.
Purity is an important indicator. High purity of 2 - (imidazole-2-yl) pyridine is necessary for many applications. To achieve high purity, its purity often needs to reach a certain proportion, such as in terms of mass fraction, or 98%, 99% or even higher. Too many impurities will affect its performance in chemical reactions, material preparation, etc.
Furthermore, the limit of impurities. The limit of related substances needs to be strictly controlled. Impurities such as intermediates and by-products produced in the synthesis process should be extremely low in content. For example, the content of specific organic impurities may not exceed a certain number of parts per million. Metal impurities cannot be ignored either, because they may affect the reaction or application of the product in some sensitive to metal ions. Such as heavy metals lead, mercury, etc., the content may need to be controlled at a very low level, measured in ppm (parts per million) or even ppb (parts per billion).
In terms of physical properties, the melting point is one of the key indicators. Pure 2- (imidazole-2-yl) pyridine should have a specific melting point range. This range or in a certain precise range, such as [specific temperature range], through the determination of the melting point, the purity and the authenticity of the substance can be preliminarily determined. Appearance is also required, usually white to off-white crystalline powder or solid. If the color and shape do not match the standard, it may also suggest poor quality.
In addition, weight loss by drying is also a factor considered by Quality Standards. The product contains too much moisture, or it affects its stability and reactivity. Therefore, the weight loss by drying should be controlled within a certain limit, such as not exceeding a certain mass percentage.
All the above Quality Standards are the key to ensure that 2 - (imidazole-2-yl) pyridine can be used normally in the fields of medicine, chemical industry, materials, etc. All of them are indispensable and need to be strictly followed and tested.