2-Hydroxymethyl-5-bromopyridine

2-Hydroxymethyl-5-bromopyridine is a kind of organic compound. Its physical properties, first of all, are often white to light yellow crystalline powder, fine and uniform in appearance, or slightly shiny in light. This is because of the regular arrangement of molecules and uniform reflection of light.
In terms of melting point, it is within a certain range, and this value is determined by the intermolecular force. The interaction of bromine atoms, hydroxymethyl groups and pyridine rings in the molecule makes the intermolecular attractive force show a specific strength, causing it to disintegrate at a specific temperature and change from solid state to liquid state.
Solubility is also an important physical property. In organic solvents such as ethanol and acetone, the compound exhibits good solubility, because these organic solvents and 2-hydroxymethyl-5-bromopyridine molecules can form hydrogen bonds or van der Waals forces, and the interaction force promotes uniform dispersion in the solvent system. However, in water, its solubility is relatively limited, because the polarity of water does not match the molecular polarity of the compound very well. Although hydroxymethyl can form hydrogen bonds with water, the hydrophobicity of bromine atoms and pyridine rings limits its solubility in water.
Furthermore, its density also has certain characteristics, and the size of the density is related to the molecular weight and the degree of molecular accumulation. The molecular mass of this compound is relatively large due to the presence of bromine atoms, and the molecules are tightly arranged in the crystal lattice, resulting in a slightly higher density than ordinary small molecule compounds.
In addition, the stability of 2-hydroxymethyl-5-bromopyridine is also a physical property consideration. Under normal temperature and pressure and dry environment, its properties are relatively stable, and the molecular structure is not easy to change spontaneously. When exposed to high temperature, strong oxidants or specific chemical reaction conditions, its molecular structure may change, because external conditions are sufficient to break the stability of the original chemical bonds in the molecule.

To prepare 2-hydroxymethyl-5-bromopyridine, there are two methods. First, 5-bromopyridine-2-formaldehyde is used as the starting material and can be obtained by reduction. In a suitable reaction bottle, add an appropriate amount of 5-bromopyridine-2-formaldehyde and dissolve it with a suitable solvent, such as methanol, ethanol and other alcoholic solvents. Then, add a reducing agent, sodium borohydride or lithium aluminum hydride are commonly used. If sodium borohydride is used, the ratio to the substrate needs to be carefully considered, generally about 1:1 to 1:3. The reaction temperature also needs to be adjusted, usually between 0 ° C and room temperature. After the reaction is completed, the pure 2-hydroxymethyl-5-bromopyridine can be obtained by post-treatment steps such as extraction, liquid separation, column chromatography, etc.
Second, 2-methyl-5-bromopyridine is used as the starting material. Shilling it reacts with N-bromosuccinimide (NBS) to introduce a bromine atom at the α-position of methyl to obtain 2- (bromomethyl) -5-bromopyridine. This reaction requires benzoyl peroxide (BPO) as the initiator and is heated and refluxed in a solvent such as carbon tetrachloride. Then 2 - (bromomethyl) - 5 - bromopyridine is treated with sodium hydroxide and other alkali solutions to hydrolyze bromomethyl into hydroxymethyl to obtain 2 - hydroxymethyl - 5 - bromopyridine. During the reaction, the concentration of the base, the reaction temperature and time need to be carefully controlled to avoid side reactions. After extraction, distillation and other operations, the target product can be obtained.

2-Hydroxymethyl-5-bromopyridine is useful in various fields. In the field of medicinal chemistry, it can be a key intermediate for the synthesis of special drugs. Because of its unique structure and active functional groups, it can be combined with other compounds through various organic reactions to prepare molecules with specific pharmacological activities. If you want to make antibacterial drugs, or you can use the reactivity of hydroxymethyl methyl and bromine atoms to construct drug structures with inhibitory or killing effects on pathogens.
In materials science, this compound is also useful. It may be used to prepare materials with special functions. For example, by polymerization, it can be connected to other monomers, or polymer materials with special optical and electrical properties can be formed. Due to the conjugated structure of the pyridine ring, it may endow the material with unique photoelectric properties, and may have potential applications in optoelectronic devices, such as organic Light Emitting Diodes (OLEDs), solar cells, etc.
In the field of organic synthesis chemistry, 2-hydroxymethyl-5-bromopyridine is often an important building block for organic synthesis. Chemists can use its bromine atom to be prone to nucleophilic substitution reactions, and hydroxymethyl can participate in various reactions such as oxidation and esterification. The synthesis route can be flexibly designed to prepare organic compounds with complex structures. No matter whether it is to build natural product analogs or new organic functional molecules, they can all rely on them as starting materials and achieve synthesis goals through ingenious reaction steps.

What you are asking about is the market price of 2-hydroxymethyl-5-bromopyridine. However, the price of this compound is difficult to determine, and it is affected by many factors.
The first to bear the brunt is the amount of production. If this product is in the market, the output is quite abundant and the supply is sufficient, its price may tend to be easy; conversely, if the output is scarce and the supply is in short supply, the price will rise.
Furthermore, the difficulty of preparation also affects its price. If the synthesis of 2-hydroxymethyl-5-bromopyridine requires complex processes, expensive raw materials, or high energy consumption, its production cost will be high, and the price will be high.
Repeat, the state of market demand is also the key. If there is strong demand for this substance in the fields of chemical industry, medicine, etc., the price may rise; if the demand is weak, the price may fall.
Also, different suppliers have different pricing strategies. Large merchants may have lower prices due to economies of scale; small merchants may have higher prices due to cost considerations.
As far as I know, in the past market, the price fluctuated from a few yuan to tens of yuan per gram. However, this is only an approximate number, and times change, and today's price may be different. For the exact price, you need to consult the chemical reagent supplier in detail, or refer to the recent market transaction records to get an accurate figure.

2-Hydroxymethyl-5-bromopyridine is also an organic compound. Its storage conditions are quite important, which is related to the stability and quality of this substance.
When stored in a cool place, because the temperature is too high, it is easy to cause chemical reactions, damage its chemical structure, and cause it to deteriorate. In a cool place, the temperature is often relatively constant, which can ensure the stability of this substance.
And must be placed in a dry place. If this compound encounters water vapor, it may hydrolyze, affecting its purity and performance. A dry environment can prevent the intrusion of water vapor and keep the substance in good condition.
Furthermore, it should be stored in a sealed container. In this way, it can prevent it from contacting the air, avoid it from being oxidized, and prevent volatilization and loss. The sealed device can effectively isolate external factors and provide a suitable storage microenvironment for it.
At the same time, it should be kept away from fire and heat sources. This compound may be flammable, and in case of open flames and hot topics, it may cause fires and endanger safety. And high temperature is not conducive to its chemical stability, so it is necessary to stay away from fire and heat sources.
Store in a place with good ventilation. Good ventilation can disperse potentially volatile gases in time, reduce the probability of explosion and other hazards, and keep the air in the storage environment fresh, which is conducive to the long-term storage of the substance.
In summary, 2-hydroxymethyl-5-bromopyridine should be stored in a cool, dry, sealed container, away from fire and heat sources, and in a well-ventilated location, so as to ensure the quality and stability of this product for subsequent use.