2-(Hydroxymethyl)-3,5-Dimethyl-4-Methoxy Pyridine

2-%28Hydroxymethyl%29-3%2C5-Dimethyl-4-Methoxy Pyridine, Chinese name 2- (hydroxymethyl) -3,5-dimethyl-4-methoxypyridine. This product is widely used in the field of pharmaceutical synthesis, like the cornerstone of the magic pill, and has made great contributions to the creation of many specific drugs. For example, in the synthesis of some cardiovascular disease treatment drugs, it is like a key drug guide, which can precisely regulate the molecular structure of drugs, improve pharmacological activity, and make drugs more effective at the root cause of diseases.
In the field of materials science, it is like a magic brush, drawing a blueprint for new functional materials. When synthesizing polymer materials with special electrical conductivity and optical properties, with its unique chemical structure, it can be ingeniously embedded in the molecular framework, endowing the material with new and excellent characteristics, making the material shine in the fields of electronic devices, optical instruments and so on.
In the field of organic synthetic chemistry, it is like a skilled craftsman, helping to build complex organic compounds. As a key intermediate, in the synthesis of a series of complex cyclic and chain-like organic molecules, with its activity check point, according to a specific reaction path, it builds an organic molecular edifice and contributes to the development of organic chemistry. With its unique chemical structure and active reaction activity, this compound has become an indispensable key role in scientific research and industrial production in many fields.

2-%28Hydroxymethyl%29-3%2C5-Dimethyl-4-Methoxy Pyridine is 2 - (hydroxymethyl) -3,5 - dimethyl - 4 - methoxy pyridine, there are several common methods for synthesizing this compound.
One is to use a suitable pyridine derivative as the starting material. 3,5 - dimethyl - 4 - methoxy pyridine can be taken first and reacted with formaldehyde and a suitable base under specific reaction conditions. The base agent can catalyze this reaction, promoting the nucleophilic addition of formaldehyde to a specific position on the pyridine ring, and then introducing hydroxymethyl groups at the 2-position of the pyridine ring, and finally generating the target product 2- (hydroxymethyl) -3,5 -dimethyl-4 -methoxypyridine. This reaction requires fine control of the reaction temperature, the proportion of reactants and the reaction time. Too high or too low temperature may affect the reaction rate and product purity.
Second, the strategy of gradually constructing the pyridine ring can also be adopted. First, the corresponding carbonyl-containing compounds, amine compounds and alcohol compounds are used as raw materials to construct the pyridine ring structure through multi-step reactions. In the process of constructing the pyridine ring, the reaction sequence is rationally designed, so that methoxy, methyl and other substituents are introduced into the appropriate position in sequence. After the initial formation of the pyridine ring, hydroxymethyl groups are introduced at the 2-position through a specific reaction. For example, a condensation reaction can be carried out first to form a pyridine ring skeleton, and then a suitable nucleophilic reagent can be used to react with a specific activity check point on the pyridine ring to introduce hydroxymethyl groups. The target product can be obtained through careful operation in multiple steps.
Third, it can also be synthesized by means of transition metal catalysis. Select suitable transition metal catalysts, such as palladium, copper, etc., and use halopyridine derivatives as substrates to react with the corresponding hydroxymethylation reagents in the presence of ligands Transition metal catalysts can effectively promote the formation of carbon-carbon or carbon-heteroatomic bonds, and precisely introduce hydroxymethyl groups into the 2-position of the pyridine ring, while maintaining the structure of 3,5-dimethyl-4-methoxy groups. This method requires harsh reaction conditions. The choice of catalyst, the structure of ligand and the reaction solvent all have a great impact on the reaction results, and careful screening and optimization are required.

2-%28Hydroxymethyl%29-3%2C5-Dimethyl-4-Methoxy+Pyridine, that is, 2- (hydroxymethyl) -3,5-dimethyl-4-methoxypyridine, this material has specific physical properties. It is a white to light yellow crystalline powder, which is pure and delicate, just like the first snow in winter, with uniform texture. This is due to the regular molecular structure and the orderly intermolecular forces, resulting in a stable appearance.
The melting point is about a specific range, which is just like a delicate threshold. At this temperature, the state of matter gradually changes. This is because when heated, the molecule is energized, the vibration intensifies, and when the energy is sufficient to overcome the lattice energy, the crystal structure disintegrates. The boiling point also has a specific value. At a specific pressure, the liquid boils and converts to a gaseous state. This is because the molecule can get rid of the liquid phase binding, reflecting the strength of the intermolecular force.
In terms of solubility, it is soluble in organic solvents such as ethanol and acetone, just like a fish entering water and quietly dispersing. Due to the principle of similar phase dissolution, its molecules have a certain polarity, which matches the polarity of organic solvents, and the intermolecular interaction promotes dissolution. Solubility in water is limited. Due to the strong polarity of water, its molecular polarity is different from it. Although hydroxymethyl can form hydrogen bonds with water, the rest of it is blocked, resulting in limited dissolution.
Density is also its characteristic. It has a fixed value under specific conditions, reflecting the mass of the substance per unit volume, and is related to the degree of molecular accumulation. The molecular structure is compact, arranged in an orderly manner, and the density is relatively high. This physical property has a significant impact on the separation, purification and preparation process, and is an important consideration for experimental operations.

2-%28Hydroxymethyl%29-3%2C5-Dimethyl-4-Methoxy Pyridine, Chinese name 2- (hydroxymethyl) -3,5-dimethyl-4-methoxy pyridine, is an organic compound. Its chemical properties are very interesting, let me tell you one by one.
First, its molecular structure contains hydroxymethyl (-CH 2O OH), which gives the compound a certain hydrophilicity. Hydrogen atoms of hydroxyl groups can participate in the formation of hydrogen bonds, resulting in specific solubility and intermolecular interactions of the substance in suitable solvents. For example, in polar solvents such as water or alcohols, it may have good solubility due to hydrogen bonding.
Furthermore, the pyridine ring is its core structure, which is aromatic and stable. However, the electron cloud distribution is affected by the methoxy group and the methyl group attached to the ring. Methyl group is a donator group, which can increase the electron cloud density of the pyridine ring. In the electrophilic substitution reaction, the reaction may occur more easily, and the localization effect is significant, guiding the substituent to a specific position. Methoxy group is also a donator group, which not only enhances the electron cloud density of the ring, but also has a great impact on the chemical activity and reaction selectivity of the pyridine ring.
In addition, different functional groups may interact with each other in this compound. For example, there are intramolecular hydrogen bonds between the hydroxyl group of the hydroxyl methyl group and the nitrogen atom of the pyridine ring, which play an important role in its molecular conformation and stability, and then affect its physical and chemical properties.
In chemical reactions, hydroxymethyl groups can participate in many reactions, such as oxidation reactions can be converted into aldehyde or carboxyl groups; they can also participate in esterification reactions to react with acids to form corresponding esters. Pyridine rings can undergo electrophilic substitution, nucleophilic substitution and other reactions, depending on the reaction conditions and reagent characteristics.

I have not heard of the price of "2- (Hydroxymethyl) -3, 5-Dimethyl-4-Methoxy Pyridine". This is a compound in the field of fine chemicals, and its market price often changes due to many reasons.
First, the price varies depending on the producer. Large factories may be able to supply it at a good price due to the benefits of scale and the refinement of the process; small factories may have different prices due to cost.
Second, the quantity is related to the price. If you buy in large quantities, you may get a wholesale price; if you buy sporadically, the price will be high.
Third, the price changes with time. The price of raw materials and the needs of the market change at any time, so that the price of this product is difficult to determine.
Fourth, the quality is good or bad, and the price is different. High purity, strict standard, the price is higher than ordinary.
To know the exact price, you can visit the chemical raw material trading platform, consult the supplier, or refer to the industry report, so that you can get a near-real price.